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Sociodemographic and clinical data, p16 status, and alcohol and tobacco consumption were extracted. Among 538 OPC cases, HPV+ accounted for 59.8% and HPV− for 40.2%. SPT prevalence was higher in HPV− (21.8%) than HPV+ (13.0%), with HPV-status associated with smoking, drinking, and nodal involvement. SPT patterns differed by HPV group, and the time to SPT diagnosis was shorter for HPV+.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-profile-and-pattern-of-second-primary-tumors-in-hpv-positive-and-hpv-negative-oropharyngeal-cancer/346004/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-profile-and-pattern-of-second-primary-tumors-in-hpv-positive-and-hpv-negative-oropharyngeal-cancer/346004.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the primary objective of the study?","Question",{"text":113,"@type":114},"To assess the clinical-epidemiological profile of patients with oropharyngeal cancer that are HPV-positive versus HPV-negative, and to compare differences in the development of second primary tumors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the study conducted?",{"text":118,"@type":114},"It used a retrospective cohort design, extracting sociodemographic and clinical data, p16 status, and alcohol and tobacco consumption, then calculating frequencies and odds ratios.",{"name":120,"@type":111,"acceptedAnswer":121},"Did SPT prevalence differ between HPV groups?",{"text":122,"@type":114},"Yes. SPT prevalence was higher among HPV− patients (21.8%) than among HPV+ patients (13.0%), and the pattern of tumor sites also differed.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},346004,1790649474,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","[www.scielo.br/rbepid](www.scielo.br/rbepid)  \nRevista Brasileira de Epidemiologia ISSN: 1980-5497  \n[https://doi.org/10.1590/1980-549720260046](https://doi.org/10.1590/1980-549720260046)  \nORIGINAL ARTICLE  \nClinical profile and pattern of second primary tumors in HPV-positive and HPV-negative oropharyngeal cancer  \nPerfil clínico e padrão de segundos tumores primários em  \ncâncer de orofaringe HPV-positivo e HPV-negativo  \nMatheus de AbreuI , Dandara Menezes de Araujo OliveiraI ,  \nJanaina Naiara GermanoI , Luiz Paulo KowalskiII , Maria Paula CuradoI   \nIA.C. Camargo Cancer Center, International Research Center, Department of Epidemiology and Statistics Nucleus – São Paulo (SP), Brazil.  \nIIA.C. Camargo Cancer Center, Department of Head and Neck Surgery and Otorhinolaryngology Department – São Paulo (SP), Brazil.  \nABSTRACT  \n\n| Objectives: To evaluate the clinical-epidemiological profile of patients with oropharyngeal cancer (OPC) positive for human papillomavirus (HPV+) and negative for human papillomavirus (HPV−), and to compare differences in the development of second primary tumors (SPT) . Methods: Retrospective cohort with patients diagnosed with OPC. Sociodemographic/clinical data, p16-status, alcohol/tobacco consumption were extracted. Absolute/relative frequencies, odds ratios (OR), prevalence of HPV and SPT were calculated. Results: Of 538 patients with OPC, 59. 8%(n=322) were HPV+; 40. 2%(n=216) HPV− . The prevalence of SPTs was higher among HPV− (21 . 8%; n=47) than HPV+ (13 . 0%; n=42) . Non-smokers were 4.5 times more likely to have HPV+ OPC (OR 4 . 58; confidence interval — CI 2.48–8. 67), and non-drinkers were 2.06 times more likely (OR=2 . 06; CI 1.15–3. 72) . Nodal involvement was associated with a 2. 77-fold higher likelihood of HPV+ (OR 2 . 77; CI 1.70–4. 56); lymphoepithelial topographies with a 2. 13-fold higher likelihood (OR 2. 13; CI 1.37–3.31) . SPTs occurred most in the skin (17 .3%, n=9) and penis/prostate (15 .4%, n=8) in HPV+, whereas in HPV- in head and neck (36 . 2%, n=22) and respiratory tract (18 . 0%, n=11) . The interval between OPC diagnosis and SPT diagnosis was shorter in the HPV+ (median: 40 months) . Conclusion: SPT pattern in OPC is not equal across HPV-groups. HPV- showed a higher prevalence of SPTs, more often involving the head and neck/respiratory tract, which may reflect the cumulative effect of tobacco/alcohol exposure. In HPV+, the lower SPT prevalence and different tumor distribution may indicate a more limited field cancerization effect. The shorter time to SPT diagnosis in HPV+ suggests that surveillance strategies may need to consider distinct risk profiles according to HPV-status. Keywords: Oropharyngeal neoplasms. Neoplasms, Second Primary. HPV. Alcohol Drinking. Tobacco Smoking. |\n| --- |\n| CORRESPONDING AUTHOR: Maria Paula Curado. Rua Tagua, 440, CEP 01508-010, São Paulo (SP), [Brazil. E-mail: mp.curado@accamargo.org.br](Brazil. E-mail: mp.curado@accamargo.org.br) |\n| CONFLICTS OF INTEREST: The authors declare no conflicts of interest related to this study. |\n| HOW TO CITE THIS ARTICLE: Abreu M, Oliveira DMA, Germano JN, Kowalski LP, Curado MP. Clinical profile and pattern of second primary tumors in HPV-positive and HPV-negative oropharyngeal câncer. Rev Bras Epidemiol 2026; 29: e260046 . [https://doi.org/10.1590/1980-549720260046](https://doi.org/10.1590/1980-549720260046) |\n| SCIENTIFIC EDITOR: Maria Fernanda Tourinho Peres  |\n\nThis is an open article distributed under the CC-BY 4.0 license, which allows copying and redistribution of the material in any format and for any purpose as long asthe original authorship and publication credits are maintained.  \nReceived on: 04/09/2026  \nAccepted on: 06/16/2026  \nHPV, associated factors and second primary tumor in oropharyngeal cancer. Rev Bras Epidemiol. 2026; 29: e260046 1  \n[www.scielo.br/rbepid](www.scielo.br/rbepid) [https://doi.org/10.1590/1980-549720260046](https://doi.org/10.1590/1980-549720260046)   \nINTRODUCTION  ","cbCaiiVlsuL7KN32","https://ap.wps.com/l/cbCaiiVlsuL7KN32","pdf",501977,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the primary objective of the study?\",\"answer\":\"To assess the clinical-epidemiological profile of patients with oropharyngeal cancer that are HPV-positive versus HPV-negative, and to compare differences in the development of second primary tumors.\"},{\"question\":\"How was the study conducted?\",\"answer\":\"It used a retrospective cohort design, extracting sociodemographic and clinical data, p16 status, and alcohol and tobacco consumption, then calculating frequencies and odds ratios.\"},{\"question\":\"Did SPT prevalence differ between HPV groups?\",\"answer\":\"Yes. SPT prevalence was higher among HPV− patients (21.8%) than among HPV+ patients (13.0%), and the pattern of tumor sites also differed.\"}]","Clinical profile and pattern of second primary tumors in HPV-positive and HPV-negative oropharyngeal cancer | PDF",1790059650,25]