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A retrospective cohort of 390 colorectal LST cases treated by endoscopy from January 2021 to August 2023 was divided into a skirt group (30) and a non-skirt group (360). Clinical and histological characteristics were compared, and independent predictors were evaluated. Results show skirt features were present in 7.69% of cases, with rectal location and diameter ≥20 mm strongly associated with skirt presence; age ≥60 years independently increased carcinogenesis risk. Findings support thorough preoperative assessment and complete endoscopic resection.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-pathological-features-and-carcinogenic-risk-factors-of-colorectal-lateral-spreading-tumors-with-skirt-features/370644/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-pathological-features-and-carcinogenic-risk-factors-of-colorectal-lateral-spreading-tumors-with-skirt-features/370644.png","ImageObject",300,407,{"name":92,"@type":93},"Melati","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this study?","Question",{"text":112,"@type":113},"To investigate clinical pathological features of colorectal lateral spreading tumors with skirt features and identify associated carcinogenic risk factors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients grouped in the study?",{"text":117,"@type":113},"A total of 390 colorectal LST cases were categorized into a skirt group (30 cases) and a group without a skirt (360 cases) based on whether skirt features were present.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were independent predictors of skirt presence in colorectal LSTs?",{"text":121,"@type":113},"Rectal lesions and lesion diameter ≥20 mm were identified as independent predictors for the presence of skirt features.",{"name":123,"@type":110,"acceptedAnswer":124},"What risk factor increased carcinogenesis in LSTs with skirt features?",{"text":125,"@type":113},"Advanced age, defined as age ≥60 years, was found to be an independent risk factor for carcinogenesis in LSTs with skirt features.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},370644,1790270314,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Wiley  \nCanadian Journal of Gastroenterology and Hepatology Volume 2025, Article ID 9920606, 7 pages [https://doi.org/10.1155/cjgh/9920606](https://doi.org/10.1155/cjgh/9920606)  \nResearch Article  \nClinical Pathological Features and Carcinogenic Risk Factors of Colorectal Lateral Spreading Tumors With Skirt Features  \nLongping Chen,1,2,3 Junguo Chen,4 Linfu Zheng, 1,2,3 Jin Zheng, 1 Binbin Xu,1 Dazhou Li,1,2,3 and Wen Wang 1,2,3  \n1 Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China 2 Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou 350025, China  \n3 Department of Gastroenterology, Dongfang Hospital of Xiamen University, School of Medicine, Xiamen University,  \nFuzhou 350025, China  \n4 West China Xiamen Hospital of Sichuan University, Xiamen 361000, China  \nCorrespondence should be addressed to Wen Wang; [wangwenfj@163.com](wangwenfj@163.com)  \nReceived 5 February 2025; Accepted 27 May 2025  \nAcademic Editor: Xingshun Qi  \nCopyright © 2025 Longping Chen et al. Canadian Journal of Gastroenterology and Hepatology published by John Wiley & Sons Ltd. Tis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nObjective: Tis study aims to investigate the clinical pathological features of colorectal lateral spreading tumors (LSTs) with skirt features and the associated carcinogenic risk factors.  \nMethods: A total of 390 cases of colorectal LSTs, treated via endoscopy at the Digestive Endoscopy Center of the 900th Hospital of the People’s Liberation Army Joint Logistics Support Force between January 2021 and August 2023, were included. Te cases were categorized into a skirt group (30 cases) and a group without a skirt (360 cases) based on the presence of skirt features. Te clinical pathological characteristics, including age, gender, endoscopic features (lesion diameter, location, morphology), and histological types, were compared between the two groups. Additionally, the risk factors for carcinogenesis in LSTs with a skirt were analyzed. Results: Among the 390 LSTs cases, 30 (7.69%) exhibited skirt features, with 23 lesions located in the rectum (76.67%) and 26 lesions having a diameter of ≥ 20 mm (86.67%). Histological classifcation revealed 10 cases (33.33%) of adenomas with low-grade intraepithelial neoplasia (LGIN), 9 cases (30.00%) of adenomas with high-GIN (HGIN), and 11 cases (36.67%) of carcinoma. Te proportions of female patients, rectal lesions, lesions with a diameter of ≥ 20 mm, mixed nodular lesions, and those classifed as carcinoma were signifcantly higher in LSTs with a skirt group compared to LSTs without a skirt group. Rectal lesions (p 􀂈 0.001, OR 􀂈 8 .588, 95% CI: 2 .428–30.379) and lesion diameters ≥ 20 mm (p 􀂈 0.008, OR 􀂈 4 .538, 95% CI: 1 .477–13.940) were identifed as independent predictors of skirt presence in colorectal LSTs. Age ≥ 60 years (p 􀂈 0.002, OR 􀂈 22.667, 95% CI: 3.140–163.629) was found to be an independent risk factor for carcinogenesis in LSTs with a skirt.  \nConclusion: Compared with LSTs without a skirt, the results indicated that LSTs with a skirt are more commonly found in female patients, predominantly has a diameter of ≥ 20 mm, typically presents as a mixed nodular type, is frequently located in the rectum, and is often classifed as carcinoma. Te presence of rectal lesions and lesion diameter ≥ 20 mm increases the likelihood of skirt features in LSTs. Furthermore, advanced age (≥ 60 years) may elevate the risk of carcinogenesis in LSTs with a skirt, necessitating thorough preoperative assessments and complete resection during endoscopic removal of such lesions.  \nKeywords: carcinogenesis; lateral spreading tumors; skirt  \n1. Introduction  \nIn 2021, there were 5.26 million new cases of gastrointestinal cancer worldwide, with approximately 3.7 m","cbCaieC1J8TMBi0M","https://ap.wps.com/l/cbCaieC1J8TMBi0M","pdf",1503068,"English","# Objective\n# Methods\n## Study design and grouping\n## Data collection and comparison\n## Risk factor analysis\n# Results\n# Conclusion\n# Introduction\n## Global burden of gastrointestinal and colorectal cancer\n## LST overview and malignant potential\n## Definition and clinical significance of skirt features","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To investigate clinical pathological features of colorectal lateral spreading tumors with skirt features and identify associated carcinogenic risk factors.\"},{\"question\":\"How were patients grouped in the study?\",\"answer\":\"A total of 390 colorectal LST cases were categorized into a skirt group (30 cases) and a group without a skirt (360 cases) based on whether skirt features were present.\"},{\"question\":\"Which factors were independent predictors of skirt presence in colorectal LSTs?\",\"answer\":\"Rectal lesions and lesion diameter ≥20 mm were identified as independent predictors for the presence of skirt features.\"},{\"question\":\"What risk factor increased carcinogenesis in LSTs with skirt features?\",\"answer\":\"Advanced age, defined as age ≥60 years, was found to be an independent risk factor for carcinogenesis in LSTs with skirt features.\"}]","Clinical Pathological Features and Carcinogenic Risk Factors of Colorectal Lateral Spreading Tumors With Skirt Features | PDF",1790189608,18]