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A retrospective cohort analyzed clinical data and tissue samples from 61 OSCC patients at a tertiary referral hospital in Jakarta. CK19 immunohistochemistry was scored using the H system; all patients were followed for at least 36 months with comparative and survival analyses. High CK19 expression showed a lower 3-year overall survival, without statistically significant clinicopathologic differences, and keratinization emerged as an independent prognostic factor.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-implications-of-cytokeratin-19-expression-in-patients-with-oral-squamous-cell-carcinoma/382744/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-implications-of-cytokeratin-19-expression-in-patients-with-oral-squamous-cell-carcinoma/382744.png","ImageObject",300,407,{"name":92,"@type":93},"Bintang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of this study?","Question",{"text":112,"@type":113},"To quantify the prevalence of high CK19 expression in Indonesian OSCC patients and to explore whether CK19 has a prognostic role in OSCC.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were CK19 expression and patient outcomes assessed?",{"text":117,"@type":113},"CK19 immunohistochemical staining was performed on tissue from 61 OSCC patients and scored using the H system. Patients were followed for at least 36 months, and survival analyses were conducted.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find regarding CK19 and survival?",{"text":121,"@type":113},"26.2% of patients had high CK19 expression. 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Clinical implications of Cytokeratin 19 expression inpatients with oral squamous cell carcinoma. Pathologica 2023;115:155-163 . [https://doi](https://doi). org/10.32074/1591-951X-842  \n© Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology  \n OPEN ACCESS  \nThis is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: [https://creativecommons](https://creativecommons). org/licenses/by-nc-nd/4.0/deed.en  \nOriginal Article  \nClinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma  \nNur Rahadiani, Sarwanti Sarwanti, Diah Rini Handjari, Marini Stephanie, Ening Krisnuhoni  \nDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Central Jakarta, Jakarta, Republic of Indonesia  \nSummary  \nObjective. This study was done to quantify the prevalence of high cytokeratin (CK) 19 expression in Indonesian oral squamous cell carcinoma (OSCC) patients and explore the prognostic role of CK19 in OSCC.  \nMethods. Clinical data and samples from 61 patients diagnosed with OSCC at a tertiary national referral hospital in Jakarta, Indonesia were analyzed in this retrospective cohort study. Immunohistochemical staining of CK19 was performed on all patients and its expression was scored using the H system. All patients were followed up for a minimum of 36 months after diagnosis. Comparative and survival analyses were performed.  \nResults. Twenty six point two percent of Indonesian OSCC patients had high CK19 expression. There were no differences in clinicopathological characteristics between patients with low and high CK19 expression. The 3-year overall survival (OS) of our cohort was 11.5% . Patients with high CK19 expression had lower 3-year OS compared to patients with low CK19 expression, even if the difference in OS was not statistically significant. Keratinization was an independent prognostic factor for survival in multivariate regression analysis. Conclusions. Data obtained here indicate a possible prognostic role of CK19 in OSCC. This prognostic role should be confirmed in larger series.  \nKey words: cytokeratin 19, Indonesia, oral squamous cell carcinoma, survival  \nIntroduction  \nCancer remains the leading cause of death in most countries throughout the world. In the International Agency for Research on Cancer’s mostrecent GLOBOCAN estimates of cancer incidence and mortality, oral cancer ranked 20th in number of estimated new cases with an estimated 377,713 new cases and 177,757 cancer deaths 1. Oral cancer may arise from the epithelium lining the lips, gums, tongue, mouth, or palate. Keratinocytes comprise a majority of this epithelium, and 90-95% of oral cancer are oral squamous cell carcinomas (OSCCs) 2.  \nCytokeratins (CKs) are intermediate filament proteins found in the cytoplasm of eukaryotic cells to maintain the cytoskeletal framework. They are specifically expressed in epithelial tissues. The expression of CKs depends on epithelium type and differentiation. CK19 is a low-molecular-weight and acidic cytokeratin expressed in simple ductal epithelium, mesothelium, and pseudostratified epithelium along with CK7 3. CK19 is ","cbCairBEWMIZ8x0V","https://ap.wps.com/l/cbCairBEWMIZ8x0V","pdf",319911,"English","# Summary\n## Objective\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Background on OSCC and CK19\n## Prognostic relevance and research gap\n# Materials and methods\n## Sample collection","[{\"question\":\"What was the main objective of this study?\",\"answer\":\"To quantify the prevalence of high CK19 expression in Indonesian OSCC patients and to explore whether CK19 has a prognostic role in OSCC.\"},{\"question\":\"How were CK19 expression and patient outcomes assessed?\",\"answer\":\"CK19 immunohistochemical staining was performed on tissue from 61 OSCC patients and scored using the H system. Patients were followed for at least 36 months, and survival analyses were conducted.\"},{\"question\":\"What did the study find regarding CK19 and survival?\",\"answer\":\"26.2% of patients had high CK19 expression. High CK19 expression was associated with lower 3-year overall survival compared with low CK19, though the difference was not statistically significant.\"}]","Clinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma | PDF",1790252161,23]