[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-148508-en":3,"doc-seo-148508-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},148508,8796095461610,"Oliver","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",7,"Healthcare","Clinical Immunology Principles and Practice - Issue - Edition","Comprehensive clinical immunology reference covering core principles of immune response, organization of the immune system, and mechanisms including innate immunity, antigen receptor genes, major histocompatibility complex functions, and antigen presentation. Describes adaptive immune cell development, T-cell activation and tolerance, helper T-cell subsets, cytotoxic lymphocytes, NK cells, and regulatory immune mechanisms. Addresses cytokines, chemokines, lymphocyte adhesion and trafficking, and host defenses across infections, immune deficiencies, genomics, regulatory RNA, immunometabolism, and microbiota-related inflammation.","CLINICAL   \nPRINCIPLES AND PRACTICE  \nThomas A. Fleisher, MD  \nExecutive Vice President  \nAmerican Academy of Allergy, Asthma, and Immunology Milwaukee, WI, United States; Scientist Emeritus National Institutes of Health Clinical Center Bethesda, MD, United States  \nHarry W. Schroeder Jr., MD, PhD  \nProfessor  \nMedicine, Microbiology, and Genetics University of Alabama at Birmingham Birmingham, AL, United States  \nCornelia M. Weyand, MD, PhD  \nProfessor Emerita Medicine Stanford University Stanford, CA, United States; Professor Medicine and Immunology Mayo Clinic Alix School of Medicine Rochester, MN, United States  \nDavid B.Corry, MD  \nProfessor Medicine and Pathology and Immunology Baylor College of Medicine Houston, TX, United States  \nJennifer M. Puck, MD  \nProfessor of Pediatrics University of California San Francisco San Francisco, CA, United States  \n© 2023, Elsevier Ltd. All rights reserved.  \nFirst edition 1996 Second edition 2001 Third edition 2008 Fourth edition 2013 Fifth edition 2019 Sixth edition 2023  \nThe right of Robert R. Rich, Thomas A. Fleisher, Harry W. Schroeder Jr., Cornelia M. Weyand, David B. Corry, and Jennifer M. Puck to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs, and Patents Act 1988.  \nNo part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies, and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency can be [found at our website:](found at our website: www.elsevier.com/permissions)[ www.elsevier.com/permissions](found at our website: www.elsevier.com/permissions).  \nThis book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein) .  \nChapter 14, Cytokines and cytokine receptors; John J. O’Shea and Massimo Gadina contributions are in the public domain.  \nChapter 15: Chemokines and Chemokine Receptors; Philip Murphy contributions are in the public domain Chapter 28: Host Defenses to Fungi; Michail S. Lionakis contributions are in the public domain Chapter 45: Eosinophils and Eosinophilic Disorders; Amy D. Klion contributions are in public domain Chapter 78, Lymphomas; Elaine S. Jaffe and Stefania Pittaluga contributions are in the public domain.  \nChapter 85, Protein kinase antagonists; John J. O’Shea and Massimo Gadina contributions are in the public domain.  \nChapter 90: Allogeneic Transplantation for Immunodeficiency is in the public domain  \nChapter 93: Flow cytometry; Sergio Rosenzweig contributions are in the public domain.  \nNotices  \nPractitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. Because of rapid advancesin the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors, or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.  \nISBN: 9780702081651  \nContent Strategists: Robin Carter, Mary Hegeler  \nContent Development Specialists: Louise Cook, Jennifer Ehlers, Malvika Shah  \nProject Manager: Andrew Riley  \nDesign: Amy Buxton  \nIllustration Manager: Deanna Sorenson  \nMarketing Manager: Kate Bresnahan  \nPrinted in India  \nLast digit is the print number: 9 8 7 6 5 4 3 2 1  \nC ONTENT S  \nPreface to the First Edition, ix Preface to the Sixth Edition, xi List of Contributors, x","cbCaij0BZX6HdPIL","https://ap.wps.com/l/cbCaij0BZX6HdPIL","pdf",74634240,1,1259,"English","en",105,"# Preface and Contributors\n## Preface to the First Edition\n## Preface to the Sixth Edition\n## List of Contributors\n## Dedication\n# Part I Principles of Immune Response\n## The Human Immune Response\n## Organization of the Immune System\n## Innate Immunity\n## Antigen Receptor Genes, Gene Products, and Co-Receptors\n## The Major Histocompatibility Complex\n## Antigens and Antigen Presentation\n## B-Cell Development and Differentiation\n## Immunoglobulin Function\n## T-Cell Development\n## T-Cell Activation and Tolerance\n## Helper T-Cell Subsets and Control of the Inflammatory Response\n## Cytotoxic T Lymphocytes and Natural Killer Cells\n## Regulatory Immune Cells\n## Cytokines and Cytokine Receptors\n## Chemokines and Chemokine Receptors\n## Lymphocyte Adhesion and Trafficking\n## Death Pathways and Immunogenicity\n# Part II Fundamentals of Host-Environmental Interactions\n## Human Genomics in Immunology\n## Regulatory RNA in Immunologic Diseases\n## Immunometabolism\n## Immune Deficiencies at the Extremes of Age\n## The Microbiota in Immunity and Inflammation","[{\"question\":\"What major topics are covered in Part I on principles of immune response?\",\"answer\":\"It covers immune system organization, innate and adaptive immunity, antigen presentation, B- and T-cell development, activation and tolerance, regulatory immune cells, and core signaling families such as cytokines and chemokines.\"},{\"question\":\"Which subjects are addressed under host-environment fundamentals in Part II?\",\"answer\":\"Part II focuses on human genomics in immunology, regulatory RNA in immune diseases, immunometabolism, immune deficiencies across age extremes, and the role of the microbiota in immunity and inflammation.\"},{\"question\":\"How does the book structure its content across immune mechanisms and clinical host defenses?\",\"answer\":\"The table of contents separates foundational immune mechanisms (Part I) from host-environment interactions (Part II), then proceeds to host defenses against infections in later sections.\"}]","Clinical Immunology Principles and Practice - Issue - Edition | PDF",1787780562,3173,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"clinical-immunology-principles-and-practice-edition","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/clinical-immunology-principles-and-practice-edition/148508/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-31","2026-08-26",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What major topics are covered in Part I on principles of immune response?","Question",{"text":76,"@type":77},"It covers immune system organization, innate and adaptive immunity, antigen presentation, B- and T-cell development, activation and tolerance, regulatory immune cells, and core signaling families such as cytokines and chemokines.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"Which subjects are addressed under host-environment fundamentals in Part II?",{"text":81,"@type":77},"Part II focuses on human genomics in immunology, regulatory RNA in immune diseases, immunometabolism, immune deficiencies across age extremes, and the role of the microbiota in immunity and inflammation.",{"name":83,"@type":74,"acceptedAnswer":84},"How does the book structure its content across immune mechanisms and clinical host defenses?",{"text":85,"@type":77},"The table of contents separates foundational immune mechanisms (Part I) from host-environment interactions (Part II), then proceeds to host defenses against infections in later sections.","https://schema.org",{"og:url":52,"og:type":88,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":90,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":93},[94,98,102,106,111,116,119,124,129,132,136],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":99,"show_sort_weight":100,"slug":101},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":103,"show_sort_weight":104,"slug":105},"Exam",70,"exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},5,"Comic",60,"comic",{"id":112,"doc_module":4,"doc_module_name":46,"category_name":113,"show_sort_weight":114,"slug":115},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":117,"slug":118},40,"healthcare",{"id":120,"doc_module":4,"doc_module_name":46,"category_name":121,"show_sort_weight":122,"slug":123},8,"Research & Report",30,"research-report",{"id":125,"doc_module":4,"doc_module_name":46,"category_name":126,"show_sort_weight":127,"slug":128},9,"Religion & Spirituality",20,"religion-spirituality",{"id":127,"doc_module":4,"doc_module_name":46,"category_name":130,"show_sort_weight":127,"slug":131},"World Cup","world-cup",{"id":133,"doc_module":4,"doc_module_name":46,"category_name":134,"show_sort_weight":133,"slug":135},10,"Lifestyle","lifestyle",{"id":137,"doc_module":4,"doc_module_name":46,"category_name":138,"show_sort_weight":107,"slug":139},19,"General","general"]