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This retrospective study summarizes experience from a Chinese medical center using data from 566 PJS patients, focusing on clinical features, diagnostic approach, and treatment outcomes, and analyzes key timing, polyp distribution, endoscopy use, complications, and age-related risks.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-features-diagnosis-and-treatment-of-peutz-jeghers-syndrome-experience-with-566-chinese-cases/375487/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-features-diagnosis-and-treatment-of-peutz-jeghers-syndrome-experience-with-566-chinese-cases/375487.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What patient cohort and period were included in this study?","Question",{"text":112,"@type":113},"The study retrospectively summarized 566 PJS cases admitted to the Air Force Medical Center from January 1994 to October 2022.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study describe the timing from mucocutaneous pigmentation to symptoms?",{"text":117,"@type":113},"Median time to mucocutaneous pigmentation was 2 years, and median time from pigmentation to abdominal symptoms was 10 years.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main age-related risks reported for PJS?",{"text":121,"@type":113},"The cumulative risk of intussusception increased with age (about 72.0% at 40 and 89.6% at 50). The cumulative risk of cancer also increased with age (about 49.3% at 50 and 71.7% at 60).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375487,1790753983,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 March 14; 29(10): 1627-1637  \nDOI: 10.3748/wjg.v29.i10.1627 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nClinical features, diagnosis, and treatment of Peutz-Jeghers syndrome: Experience with 566 Chinese cases  \nZu-Xin Xu, Li-Xin Jiang, Yu-Rui Chen, Yu-Hui Zhang, Zhi Zhang, Peng-Fei Yu, Zhi-Wei Dong, Hai-Rui Yang, Guo-Li Gu  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B, B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Awai K, Japan; Sjoblom T, Sweden  \nReceived: December 12, 2022  \nPeer-review started: December 12, 2022  \nFirst decision: January 11, 2023  \nRevised: January 17, 2023  \nAccepted: February 16, 2023  \nArticle in press: February 16, 2023  \nPublished online: March 14, 2023  \nZu-Xin Xu, Fifth Clinical College of Anhui Medical University, Air Force Clinical College of Anhui Medical University, Beijing 100142, China  \nLi-Xin Jiang, Yu-Rui Chen, Air Force Clinical College of China Medical University, Beijing 100142, China  \nYu-Hui Zhang, Zhi Zhang, Peng-Fei Yu, Zhi-Wei Dong, Hai-Rui Yang, Guo-Li Gu, Department of General Surgery, Air Force Medical Center, Chinese People's Liberation Army, Beijing 100142, China  \nCorresponding author: Guo-Li Gu, FRCS (Gen Surg), Chief Doctor, Department of General Surgery, Air Force Medical Center, Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, [China.](China. kzggl@163.com)[ kzggl@163.com](China. kzggl@163.com)  \nAbstract  \nBACKGROUND  \nPeutz-Jeghers syndrome (PJS) is a clinically rare disease with pigmented spots on the lips and mucous membranes and extremities, scattered gastrointestinal polyps, and susceptibility to tumors as clinical manifestations. Effective preventive and curative methods are still lacking. Here we summarize our experience with 566 Chinese patients with PJS from a Chinese medical center with regard to the clinical features, diagnosis, and treatment.  \nAIM  \nTo explore the clinical features, diagnosis, and treatment of PJS in a Chinese medical center.  \nMETHODS  \nThe diagnosis and treatment information of 566 cases of PJS admitted to the Air Force Medical Center from January 1994 to October 2022 was summarized. A clinical database was established covering age, gender, ethnicity, family history, age at first treatment, time and sequence of appearance of mucocutaneous pigmentation, polyp distribution, quantity, and diameter, frequency of hospitalization, fre-quency of surgical operations, etc. The clinical data was retrospectively analyzed using SPSS 26.0 software, with P \u003C 0.05 considered statistically significant.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1627 March 14, 2023  Volume 29  Issue 10   \nXu ZX et al. Diagnosis and treatment of Chinese PJS patients  \nRESULTS  \nOf all the patients included, 55.3% were male and 44.7% were female. Median time to the appearance of mucocutaneous pigmentation was 2 years, and median time from the appearance of mucocutaneous pigmentation to the occurrence of abdominal symptoms was 10 years. The vast majority (92.2%) of patients underwent small bowel endoscopy and treatment, with 2.3% having serious complications. There was a statistically significant difference in the number of enteroscopies between patients with and without canceration (P = 0.004, Z = -2.882); 71.2% of patients underwent surgical operation, 75.6% of patients underwent surgical operation before the age of 35 years, and there was a statistically significant difference in the frequency of surgical operations between patients with and","cbCairUmAMuESzAV","https://ap.wps.com/l/cbCairUmAMuESzAV","pdf",775148,12,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Citation\n# Introduction","[{\"question\":\"What patient cohort and period were included in this study?\",\"answer\":\"The study retrospectively summarized 566 PJS cases admitted to the Air Force Medical Center from January 1994 to October 2022.\"},{\"question\":\"How did the study describe the timing from mucocutaneous pigmentation to symptoms?\",\"answer\":\"Median time to mucocutaneous pigmentation was 2 years, and median time from pigmentation to abdominal symptoms was 10 years.\"},{\"question\":\"What were the main age-related risks reported for PJS?\",\"answer\":\"The cumulative risk of intussusception increased with age (about 72.0% at 40 and 89.6% at 50). The cumulative risk of cancer also increased with age (about 49.3% at 50 and 71.7% at 60).\"}]","Clinical features, diagnosis, and treatment of Peutz-Jeghers syndrome - Experience with 566 Chinese cases | PDF",1790215149]