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Male patients with elderly-onset DM symptoms showed increased lung cancer susceptibility, with higher smoking history and specific clinical, immunologic, and laboratory patterns. Multivariate modeling identified smoking history, elevated monocyte-to-lymphocyte ratio (MLR), and anti-TIF1-γ-Ab positivity as independent risk factors, suggesting that ILD may be protective.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/clinical-features-and-risk-factors-of-lung-cancer-in-elderly-patients-with-dermatomyositis/405598/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/clinical-features-and-risk-factors-of-lung-cancer-in-elderly-patients-with-dermatomyositis/405598.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study designed to determine in elderly dermatomyositis patients?","Question",{"text":63,"@type":64},"The study aimed to describe clinical and immunological features of lung cancer in elderly DM patients and to identify risk factors associated with the presence of lung cancer by comparing patients with and without lung cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which factors were independently associated with lung cancer presence?",{"text":68,"@type":64},"Smoking history, elevated monocyte-to-lymphocyte ratio (MLR), and anti-TIF1-γ-Ab positivity were independently associated with lung cancer in elderly DM patients. ILD was reported as a potential protective factor.",{"name":70,"@type":61,"acceptedAnswer":71},"What screening groups does the study recommend for lung cancer among elderly DM patients?",{"text":72,"@type":64},"Screening is considered necessary for elderly DM patients who have a history of smoking, elevated MLR, or are anti-TIF1-γ-Ab positive.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},405598,1790718862,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10.1111/1759-7714.14849  \nORIGINA L ARTICLE  \nClinical features and risk factors of lung cancer in elderly patients with dermatomyositis  \nBaiyu Zhou 1 | Shu Li 2  | Xi Xie 2 | Suqing Xu 2 | Fen Li 2 | Liuxin Long 2  \n1Beijing Hospital, National Center for Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China  \n2Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, China  \nCorrespondence  \nShu Li, Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, No.139 Ren Min Middle Road, Changsha, Hunan 410011, China.  \nEmail: [lishu0731@csu.edu.cn](lishu0731@csu.edu.cn)  \nFunding information  \nHunan Provincial Natural Science Foundation of China, Grant/Award Number: 2022JJ30815; National Natural Science Foundation of China, Grant/Award Number: 81302567  \nAbstract  \nBackground: Although there are concerns about the association between dermatomyositis (DM) and malignancy, the clinical features in elderly DM patients with lung cancer are largely unknown. Here, we elucidated the clinical features and risk factors of lung cancer in elderly DM patients.  \nMethods: The data of elderly DM patients (≥65 years old) with or without lung cancer admitted to the Second Xiangya Hospital, Central South University from January 2016 to November 2022 were retrospectively analyzed.  \nResults: Male patients with elderly onset DM (EODM) symptoms were found to be prone to lung cancer (p \u003C 0.001). Elderly DM patients with lung cancer had a higher ratio of a history of smoking and were more likely to present with heliotrope rash, V sign and dysphasia and elevated monocyte-to-lymphocyte ratio (MLR) and there was a higher ratio of anti-TIF1-γ-Ab-positive patients (all p \u003C 0.05). Occurrence of interstitial lung disease (ILD), elevated aspartate aminotransferase (AST) and anti-aminoacyl-tRNA synthetase (anti-ARS)-antibody positive rates were less common in elderly DM patients with lung cancer than those without lung cancer (all p \u003C 0.05). Multivariate logistic regression analysis showed smoking history (p = 0.011, OR = 4.532), elevated MLR (p = 0.018, OR = 1.159) and anti-TIF1-γ-Ab-positive status (p = 0.034, OR = 8.529) were independently associated with the presence of lung cancer, while ILD might be a protective factor (p = 0.024, OR = 0.179) for lung cancer in elderly patients with DM.  \nConclusions: Lung cancer is more common in male patients with EODM symptoms. Smoking, elevated MLR and being anti-TIF1-γ-Ab-positive were associated with higher frequencies of lung cancer in elderly DM patients. It is necessary to screen lung cancer in elderly DM patients with a history of smoking, elevated MLR or being antiTIF1-γ-Ab-positive.  \nKEYW ORD S  \ndermatomyositis, elderly people, interstitial lung disease, lung cancer, myositis specific antibody  \nINTRODUCTION  \nDermatomyositis (DM), an uncommon chronic autoimmune disease, is a kind of idiopathic inflammatory myopathy (IIM) characterized by muscle pain and weakness, unique skin  \nAbbreviations: ARS, anti-aminoacyl-tRNA synthetase; AST, aspartate aminotransferase; DM, Dermatomyositis; ILD, Interstitial lung disease; lab, laboratory; TIF1-γ, anti-transcriptional intermediary factor 1-γ .  \nfindings, such as heliotrope rash, or gottron’s papules, or gottron’s sign, or V-sign or shawl sign, etc.1 In recent years, a relationship between DM and malignancy has been well established.2,3 Immune dysfunction, chronic inflammation, older age and immunosuppressive therapy for DM have been linked to an increased incidence of malignancy.4 It has been reported that malignancies are detected in approximately 10%–47% of DM patients and associated with high mortality.5 Therefore, identifying the potential high-risk factors for malignancy is  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and dis","cbCaigkCfHDISn7j","https://ap.wps.com/l/cbCaigkCfHDISn7j","pdf",650108,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the study designed to determine in elderly dermatomyositis patients?\",\"answer\":\"The study aimed to describe clinical and immunological features of lung cancer in elderly DM patients and to identify risk factors associated with the presence of lung cancer by comparing patients with and without lung cancer.\"},{\"question\":\"Which factors were independently associated with lung cancer presence?\",\"answer\":\"Smoking history, elevated monocyte-to-lymphocyte ratio (MLR), and anti-TIF1-γ-Ab positivity were independently associated with lung cancer in elderly DM patients. ILD was reported as a potential protective factor.\"},{\"question\":\"What screening groups does the study recommend for lung cancer among elderly DM patients?\",\"answer\":\"Screening is considered necessary for elderly DM patients who have a history of smoking, elevated MLR, or are anti-TIF1-γ-Ab positive.\"}]","Clinical features and risk factors of lung cancer in elderly patients with dermatomyositis | PDF",1790560879]