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This study investigated risk factors and outcomes for thromboembolism in elderly patients with stage IV lung cancer. Metastatic cases aged over 60 were screened from 2011 to 2019, and univariable and multivariable analyses were used to identify predictors. Prognosis was assessed using log-rank tests and multivariate Cox regression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-characteristics-and-prognosis-of-thromboembolism-in-elderly-patients-with-stage-iv-lung-cancer/353515/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-characteristics-and-prognosis-of-thromboembolism-in-elderly-patients-with-stage-iv-lung-cancer/353515.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main goal for elderly patients with stage IV lung cancer?","Question",{"text":112,"@type":113},"To identify risk factors and determine the prognosis of thromboembolism in elderly patients with stage IV lung cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which variables were associated with venous thromboembolism (VTE) risk?",{"text":117,"@type":113},"Body mass index (BMI) and D-dimer level were independent risk factors associated with VTE.",{"name":119,"@type":110,"acceptedAnswer":120},"How did arterial thromboembolism (ATE) affect overall survival?",{"text":121,"@type":113},"Older patients with ATE had shorter overall survival, with an associated duration of about 7 months, and ATE corresponded to a poorer prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353515,1790207345,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Geriatrics & Gerontology International  \n ORIGINAL ARTICLE  OPEN ACCESS   \nEPIDEMIOLOGY CLINICAL PRACTICE AND HEALTH  \nClinical Characteristics and Prognosis of Thromboembolism in Elderly Patients With Stage IV Lung Cancer  \nYa Qin  | Xiao Liang | Xia Sun | Shuai Yan | Nanyao Wang | Qiong Wang | Dan Wu Department of Oncology, the Affiliated Jiangyin Hospital of Nantong University, Jiangyin, People's Republic of China Correspondence: Qiong Wang ([wangqiong55@hotmail.com](wangqiong55@hotmail.com)) | Dan Wu ([wudan96121@163.com](wudan96121@163.com))  \nReceived: 20 April 2025 | Revised: 12 November 2025 | Accepted: 25 December 2025  \nKeywords: arterial thromboembolism | elderly patients with stage IV lung cancer | prognosis | risk factor | venous thromboembolism  \nABSTRACT  \nBackground: Lung cancer is associated with a high risk of thromboembolism. The incidence and mortality of lung cancer increased in the population over 60 years old. Our research aimed to reveal the risk factors and prognosis of thromboembolism in elderly patients with stage IV lung cancer.  \nMethods: Metastatic lung cancer patients over 60years of age at the Affiliated Jiangyin Hospital of Nantong University between 1 January 2011 and 30 June 2019 were screened. Univariable and multivariable analyses were conducted to reveal the risk factors for thromboembolism. Log-rank test and multivariate Cox regression analysis were performed to determine the prognosis of this cohort.  \nResults: Four hundred and fourteen-patients included in this study, 33 developed venous thromboembolism (VTE), and 39 developed arterial thromboembolism (ATE), respectively. Body mass index (BMI) and D-dimer level were independent risk factors associated with VTE. History of hypertension was an independent risk factor related to ATE. Older patients with ATE were associated with shorter overall survival (OS) of 7 months.  \nConclusions: Higher levels of BMI and D-dimer were related to VTE, while hypertension was related to ATE. ATE was associated with a poorer prognosis. In clinical practice, appropriate prevention and treatment of thromboembolism should be conducted in this cohort.  \n1 | Introduction  \nThe relationship between potential cancer and thromboembolism was first described by Trousseau in 1865 [1] . Patients with cancer are more prone to develop thromboembolism because of a hypercoagulable state [2] . Thromboembolism consists of venous and arterial thromboembolism (VTE/ATE) . VTE mainly includes deep vein thrombosis (DVT), pulmonary embolism (PE), and splanchnic vein thrombosis (SVT), which is a common complication of cancer with the second leading cause of mortality in cancer patients [3, 4] . ATE includes ischemic stroke, acute  \ncoronary syndrome (ACS), and acute peripheral artery occlusion. Compared with VTE, ATE is relatively uncommon among people living with cancer [5] . According to previous studies in cancer patients, the 2-year cumulative incidences of VTE and ATE were 8.7% and 2.6%, respectively [5, 6] .  \nIn western countries, the number of new cases of advanced lung cancer has decreased in the past few years, while localized-stage lung cancer incidence increased suddenly by 4.5% annually [7] . However, the incidence is still on the rise in China [8]. Nowadays, nearly one-third of lung cancer cases and cancer-related deaths  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2026 The Author(s). Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society.  \nGeriatrics & Gerontology International, 2026; 26:e70325 1 of 13  \n[https://doi.org/10.1111/ggi.70325](https://doi.org/10.1111/ggi.70325)  \nworldwide occurred in China [9, 10] . Compared with the improved survival rates for all cancers, the lung cance","cbCaisspsGfky5rn","https://ap.wps.com/l/cbCaisspsGfky5rn","pdf",1012656,13,"English","# Introduction\n# Materials and Methods\n## Study Design and Patients","[{\"question\":\"What was the study’s main goal for elderly patients with stage IV lung cancer?\",\"answer\":\"To identify risk factors and determine the prognosis of thromboembolism in elderly patients with stage IV lung cancer.\"},{\"question\":\"Which variables were associated with venous thromboembolism (VTE) risk?\",\"answer\":\"Body mass index (BMI) and D-dimer level were independent risk factors associated with VTE.\"},{\"question\":\"How did arterial thromboembolism (ATE) affect overall survival?\",\"answer\":\"Older patients with ATE had shorter overall survival, with an associated duration of about 7 months, and ATE corresponded to a poorer prognosis.\"}]","Clinical Characteristics and Prognosis of Thromboembolism in Elderly Patients With Stage IV Lung Cancer | PDF",1790105880,33]