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This original research summarizes clinical experience using ICG fluorescence navigation in children with renal cancer, evaluating safety and feasibility. Clinical features, ICG dosing regimens, intraoperative visualization using near-infrared radiography in vivo and ex vivo, and corresponding pathology results are analyzed. Findings include successful tumor visualization in most cases, sentinel lymph node localization in selected patients, and no ICG-related adverse reactions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-application-of-indocyanine-green-fluorescence-imaging-navigation-for-pediatric-renal-cancer/384744/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-application-of-indocyanine-green-fluorescence-imaging-navigation-for-pediatric-renal-cancer/384744.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of using ICG fluorescence imaging navigation in pediatric renal cancer surgery?","Question",{"text":113,"@type":114},"The study aims to summarize experience with ICG fluorescence imaging in pediatric renal cancers and to assess its safety and feasibility in helping visualization during surgery.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was ICG administered and what visualization outcomes were reported?",{"text":118,"@type":114},"Tumors were targeted with intraoperative intravenous ICG injections (2.5–5 mg, 0.05–0.67 mg/kg). Tumor visualization was achieved in most cases in vivo or ex vivo, with one failure linked to preoperative renal artery embolization. Sentinel lymph node fluorescent localization was achieved in three patients after injecting ICG into normal renal tissue during the operation.",{"name":120,"@type":111,"acceptedAnswer":121},"Did the study observe any ICG-related adverse reactions?",{"text":122,"@type":114},"No ICG-related adverse reactions were found in any patients during or after the operation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},384744,1790532218,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","TYPE Original Research PUBLISHED 05 May 2023  \nDOI 10.3389/fped.2023.1108997  \nEDITED BY  \nYi Ji,  \nSichuan University, China  \nREVIEWED BY  \nGianantonio Manzoni,  \nIRCCS Ca ’Granda Foundation Maggiore Policlinico Hospital, Italy  \nWang Zuopeng,  \nFudan University, China  \n*CORRESPONDENCE  \nHong Qin  \n [qinhong999999@163.com](qinhong999999@163.com)[ ](qinhong999999@163.com)Huanmin Wang  \n [wanghuanmin@bch.com.cn](wanghuanmin@bch.com.cn)[ ](wanghuanmin@bch.com.cn)†These authors share first authorship RECEIVED 27 November 2022 ACCEPTED 18 April 2023  \nPUBLISHED 05 May 2023  \nCITATION  \nFeng J, Yang W, Qin H, Xu J, Liu S, Han J, Li N, He L and Wang H (2023) Clinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer.  \nFront. Pediatr. 11:1108997 .  \ndoi: 10.3389/fped.2023.1108997  \nCOPYRIGHT  \n© Feng, Yang, Qin, Xu, Liu, Han, Li, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nClinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer  \nJun Feng1†, Wei Yang1†, Hong Qin1*, Jiatong Xu2, Shan Liu1, Jianyu Han1, Ning Li3, Lejian He2 and Huanmin Wang1*  \n1Department of Surgical Oncology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China, 2Department of Pathology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China, 3Department of Surgical Urology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China  \nBackground: Indocyanine Green (ICG) fluorescence imaging has been widely used in the surgical treatment of adult renal cancers, but its application in pediatric renal cancers has rarely been reported. This study aims to summarize the experience of ICG fluorescence imaging in pediatric renal cancers and explores its safety and feasibility.  \nMethods: The clinical features, surgical information, ICG administration regimen, near infrared radiography data in vivo and ex vivo and pathological results of children with renal cancers using ICG navigation were analyzed and summarized. Results: There were 7 cases of renal cancer, including 4 cases of Wilms tumor (WT), 1 case of malignant rhabdoid tumor of the kidney (MRTK) and 2 cases of renal cell carcinoma (RCC) . By intraoperative intravenous injection of ICG from 2. 5 to 5 mg (0 .05–0. 67 mg/kg), the tumors were visualized in 6 cases in vivo or ex vivo, and the tumor visualization failed in 1 case due to renal artery embolization before operation. By injecting 5 mg ICG into the normal renal tissue during the operation, 3 patients achieved fluorescent localization of sentinel lymph nodes. No ICG-related adverse reactions were found in any of the patients during or after operation.  \nConclusions: ICG fluorescence imaging is safe and feasible for renal cancers in children. Intraoperative administration can achieve tumor and sentinel lymph node visualization which will facilitate the development of nephron sparing surgery (NSS) . However, the technique is affected by ICG dose, anatomical conditions around the tumor, and renal blood flow. A proper dose of ICG and the complete removal of perirenal fat are helpful for the fluorescence imaging of the tumor. It has potential in the operation of renal cancer in children.  \nKEYWORDS  \nindocyanine green (ICG), fluorescence imaging, children, renal cancer, clinical application  \nAbbreviations  \nICG, Indocyanine Green; TBR, Tumor-Background Ratio; RCC, Renal Cell Carcinoma; NSS, Nephron Sparing Surgery","cbCaiiIy1RXLOdwg","https://ap.wps.com/l/cbCaiiIy1RXLOdwg","pdf",33285489,13,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Keywords\n## Abbreviations","[{\"question\":\"What is the purpose of using ICG fluorescence imaging navigation in pediatric renal cancer surgery?\",\"answer\":\"The study aims to summarize experience with ICG fluorescence imaging in pediatric renal cancers and to assess its safety and feasibility in helping visualization during surgery.\"},{\"question\":\"How was ICG administered and what visualization outcomes were reported?\",\"answer\":\"Tumors were targeted with intraoperative intravenous ICG injections (2.5–5 mg, 0.05–0.67 mg/kg). Tumor visualization was achieved in most cases in vivo or ex vivo, with one failure linked to preoperative renal artery embolization. Sentinel lymph node fluorescent localization was achieved in three patients after injecting ICG into normal renal tissue during the operation.\"},{\"question\":\"Did the study observe any ICG-related adverse reactions?\",\"answer\":\"No ICG-related adverse reactions were found in any patients during or after the operation.\"}]","Clinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer | PDF",1790264815,33]