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Results show CLEC7A is upregulated in gliomas, increases with tumor malignancy, and acts as an independent prognostic factor linked to immune function. Mechanistically, CLEC7A associates with M2 macrophages, confirmed by single-cell analysis, immunofluorescence, and correlation studies; CLEC7A knockout in M2 cells reduces chemotaxis and polarization factors.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/clec7a-regulates-m2-macrophages-to-suppress-the-immune-microenvironment-and-implies-poorer-prognosis-of-glioma/342886/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/clec7a-regulates-m2-macrophages-to-suppress-the-immune-microenvironment-and-implies-poorer-prognosis-of-glioma/342886.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the main purpose of studying CLEC7A in glioma?","Question",{"text":62,"@type":63},"To evaluate CLEC7A’s prognostic significance and its potential for immune therapy in gliomas using bioinformatics and clinical pathological analyses.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How does CLEC7A expression relate to glioma prognosis?",{"text":67,"@type":63},"CLEC7A is upregulated in gliomas, rises with tumor malignancy, and functions as an independent prognostic factor.",{"name":69,"@type":60,"acceptedAnswer":70},"What role does CLEC7A play in macrophages?",{"text":71,"@type":63},"CLEC7A is strongly associated with M2 macrophages; 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Immunol. 15:1361351 .  \ndoi: 10.3389/fimmu.2024.1361351  \nCOPYRIGHT  \n© 2024 Wang, Li, Wang, Li, Gao, Xu, Peng, Zhang, Zhang, Zhou, Xu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCLEC7A regulates M2 macrophages to suppress the immune microenvironment and implies poorer prognosis of glioma  \nJinchao Wang 1†, Xiaoru Li 2†, Kai Wang 2, Kaiji Li 1, Yalong Gao 3, Jianye Xu 1, Ruilong Peng 1, Xu Zhang 4, Shu Zhang 1*,  \nYuan Zhou 5*, Shangchen Xu 2* and Jianning Zhang 1*  \n1 Key Laboratory of Post-Neuro Injury, Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China, 2 Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University,  \nJinan, China, 3 Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China, 4School of Medicine, Nankai University, Tianjin, China, 5 Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China  \nBackground: Gliomas constitute a category of malignant tumors originating from brain tissue, representing the majority of intracranial malignancies. Previous research has demonstrated the pivotal role of CLEC7A in the progression of various cancers, yet its specific implications within gliomas remain elusive. The primary objective of this study was to investigate the prognostic significance and immune therapeutic potential of CLEC7A in gliomas through the integration of bioinformatics and clinical pathological analyses.  \nMethods: This investigation involved examining and validating the relationship between CLEC7A and glioma using samples from Hospital, along with data from TCGA, GEO, GTEx, and CGGA datasets. Subsequently, we explored its prognostic value, biological functions, expression location, and impact on immune cells within gliomas. Finally, we investigated its potential impact on the chemotaxis and polarization of macrophages.  \nResults: The expression of CLEC7A is upregulated in gliomas, and its levels escalate with the malignancy of tumors, establishing it as an independent prognostic factor. Functional enrichment analysis revealed a significant correlation between CLEC7A and immune function. Subsequent examination of immune cell differential expression demonstrated a robust association between CLEC7A and M2 macrophages. This conclusion was further substantiated through single-cell analysis, immunofluorescence, and correlation studies. Finally, the knockout of CLEC7A in","cbCaijzVbWtf18mn","https://ap.wps.com/l/cbCaijzVbWtf18mn","pdf",5710371,15,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What is the main purpose of studying CLEC7A in glioma?\",\"answer\":\"To evaluate CLEC7A’s prognostic significance and its potential for immune therapy in gliomas using bioinformatics and clinical pathological analyses.\"},{\"question\":\"How does CLEC7A expression relate to glioma prognosis?\",\"answer\":\"CLEC7A is upregulated in gliomas, rises with tumor malignancy, and functions as an independent prognostic factor.\"},{\"question\":\"What role does CLEC7A play in macrophages?\",\"answer\":\"CLEC7A is strongly associated with M2 macrophages; knocking out CLEC7A in M2 cells reduces macrophage chemotaxis and polarization factors.\"}]","CLEC7A regulates M2 macrophages to suppress the immune microenvironment and implies poorer prognosis of glioma | PDF",1790048635,38]