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The 5th edition of the WHO/IARC classification for head and neck tumors revises the “Oral Cavity and Mobile Tongue” chapter, reorganizing epithelial tumors by tumor behavior and adding categories relevant to uncertain histogenesis. Emphasis is placed on verrucous carcinoma and carcinoma cuniculatum, highlighting their clinical and histologic distinctiveness, epidemiology, pathogenesis, and prognostic factors to improve detailed, subtype-focused diagnostic understanding.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/classificatory-updates-in-verrucous-and-cuniculatum-carcinomas-insights-from-the-5th-edition-of-who-iarc-head-and-neck-tumor-classification/332018/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/classificatory-updates-in-verrucous-and-cuniculatum-carcinomas-insights-from-the-5th-edition-of-who-iarc-head-and-neck-tumor-classification/332018.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-13","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of the WHO Blue Books in cancer diagnosis?","Question",{"text":112,"@type":113},"They provide standardized diagnostic tools and nomenclature for human cancers, helping harmonize classification practices. 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Regular updates in this classification accommodate emerging molecular discoveries, advances in immunohistochemical techniques, and evolving clinical insights. The 5th edition of the WHO/IARC classification of head and neck tumors refines the 'Oral Cavity and Mobile Tongue' chapter, including sections for non-neoplastic lesions, epithelial tumors, and tumors of uncertain histogenesis. Notably, the epithelial tumors section is rearranged by tumor behavior, starting with benign squamouspapillomas and progressing through potentially malignant oral disorders to oralsquamous cell carcinoma (OSCC) . The section on OSCC reflects recent information on epidemiology, pathogenesis, and histological prognostic factors. Noteworthy is the specific categorization of verrucous carcinoma (VC) and carcinoma cuniculatum (CC), both associated with the oral cavity and distinct in clinical and histologic characteristics. This classification adjustment emphasizes the oral cavity as their predominant site in the head and neck. Designating specific sections for VC and CC aims to provide comprehensive insights into these unique subtypes, elucidating their clinical features, distinct histological characteristics, prevalence, significance, and clinical relevance. By categorizing these subtypes into specific sections, the 5th edition of the WHO classification aims to provide a more nuanced and detailed account, enhancing our understanding of these specific variants within the broader spectrum of head and neck tumors.  \nKey Words: World Health Organization; Squamous cell carcinoma of head and neck;  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 464 April 24, 2024  Volume 15  Issue 4   \nSilveira FM et al. Verrucous carcinoma and carcinoma cuniculatum classification  \nVerrucous carcinoma; Mouth neoplasms  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: The collaboration between the International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) has produced indispensable 'W","cbCaifBywAxt6IJ9","https://ap.wps.com/l/cbCaifBywAxt6IJ9","pdf",381055,"English","# Editorial\n## Classificatory updates and WHO/IARC 5th edition revisions\n## Specific sections for verrucous carcinoma and carcinoma cuniculatum\n## Clinical relevance and implications for diagnosis","[{\"question\":\"What is the purpose of the WHO Blue Books in cancer diagnosis?\",\"answer\":\"They provide standardized diagnostic tools and nomenclature for human cancers, helping harmonize classification practices. Updates incorporate new molecular and immunohistochemical evidence and evolving clinical insights.\"},{\"question\":\"What changes does the 5th edition make to the “Oral Cavity and Mobile Tongue” chapter?\",\"answer\":\"It refines the chapter structure by including sections for non-neoplastic lesions, epithelial tumors, and tumors of uncertain histogenesis. Epithelial tumors are rearranged according to tumor behavior.\"},{\"question\":\"Why are verrucous carcinoma and carcinoma cuniculatum given specific attention in the classification?\",\"answer\":\"They are categorized into dedicated sections because they show distinct clinical and histologic characteristics and are associated predominantly with the oral cavity. The update aims to clarify their clinical features, histology, prevalence, and clinical relevance.\"}]","Classificatory updates in verrucous and cuniculatum carcinomas - Insights from the 5th edition of WHO-IARC head and neck tumor classification | PDF",1789996326,13]