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It also summarizes electroclinical features of common epilepsy syndromes and the diagnostic approach for new-onset seizures.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the ILAE definition of epilepsy change over time (2005 to 2014)?",{"text":68,"@type":64},"The 2005 ILAE definition characterizes epilepsy as an enduring predisposition to generate epileptic seizures with major neurobiological consequences, applied practically as at least two unprovoked seizures more than 24 hours apart. The 2014 practical definition allows diagnosis after a single unprovoked seizure when factors indicate high likelihood of recurrence due to a persistently lowered seizure threshold.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is a systematic classification approach important for diagnosis and care?",{"text":72,"@type":64},"A systematic approach helps select appropriate diagnostic tests and treatment strategies. 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The International League Against Epilepsy (ILAE) Classification of the Epilepsies (2017) introduces a three-tiered framework. The levels focus on the determination of seizure type, epilepsy type, and identification of epilepsy syndrome, when applicable. The 2017 ILAE classification emphasizes the evaluation of the underlying etiology of epilepsy and the identification of associated comorbidities at all stages of classification. Epilepsy syndromes often have age-dependent symptoms.  \nESSENTIAL POINTS: A systematic approach to the classification of seizures and epilepsy is essential for the selection of appropriate diagnostic tests and treatment strategies. An accurate classification not only facilitates clinical assessment but has important implications in the determination of prognosis.  \nINTRODUCTION  \nE  \npilepsy is a prevalent neurologic condition that is frequently accompanied by psychiatric comorbidities in both adults and children. Moreover, it is closely associated with social stigma.1,2 A global meta-analysis of 222 studies found the point prevalence of active epilepsy to be 6.38 per 1000 individuals and a lifetime prevalence of  \n7.60 per 1000 individuals.3 It is estimated that 1 in 26 individuals in the United States have epilepsy.4 A methodical approach to classifying epilepsies is vital for precise diagnosis of seizure and epilepsy type, identification of relevant epilepsy syndromes, treatment optimization, and determination of patient outcomes. In this article, electroclinical features of common epilepsy syndromes are summarized. Additionally, this article details key semiologic characteristics of seizures and provides an overview of the diagnostic approach for new-onset seizures.  \n14 FEBRUARY 2025  \nCopyright © American Academy of Neurology. Unauthorized reproduction of this article is prohibited.  \nDEFINITION OF EPILEPSY  \nIn 2005, the International League Against Epilepsy (ILAE) defined epilepsy as“a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition,” which has been practically applied as at least two unprovoked seizures separated by more than 24 hours.5,6 The 2014 practical definition broadens its scope, allowing epilepsy to be diagnosed even after a single unprovoked seizure if specific factors indicate a high likelihood of recurring seizures due to a persistently lowered seizure threshold.5  \nAccording to the 2014 definition, a person is said to have epilepsy if they have had at least two unprovoked (or reflex) seizures occurring more than 24 hours apart or one unprovoked (or reflex) seizure, coupled with a probability of further seizures that is similar to the general recurrence risk (at least 60%) after two unprovoked seizures projected over the next decade, or medical diagnosis of an epilepsy syndrome (TABLE 1-1) .  \nIt is also important to note that epilepsy does not always last a lifetime; it can ","cbCaiuhtf2hj66ji","https://ap.wps.com/l/cbCaiuhtf2hj66ji","pdf",20644773,24,"English","# Abstract\n# Introduction\n# Definition of Epilepsy\n# Evolution of Epilepsy Classification\n# Overview of ILAE 2017 Classification","[{\"question\":\"What does the article aim to provide readers about epilepsy?\",\"answer\":\"It provides a foundational understanding of epilepsy classification and a strategic approach to diagnosing seizures and epilepsy. It also summarizes electroclinical features of common epilepsy syndromes and the diagnostic approach for new-onset seizures.\"},{\"question\":\"How did the ILAE definition of epilepsy change over time (2005 to 2014)?\",\"answer\":\"The 2005 ILAE definition characterizes epilepsy as an enduring predisposition to generate epileptic seizures with major neurobiological consequences, applied practically as at least two unprovoked seizures more than 24 hours apart. The 2014 practical definition allows diagnosis after a single unprovoked seizure when factors indicate high likelihood of recurrence due to a persistently lowered seizure threshold.\"},{\"question\":\"Why is a systematic classification approach important for diagnosis and care?\",\"answer\":\"A systematic approach helps select appropriate diagnostic tests and treatment strategies. Accurate classification supports clinical assessment and also influences prognosis determination.\"}]","Classification and Diagnosis of Epilepsy - Review Article | PDF",1792538779]