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End-stage renal disease (ESRD) is identified when death is probable without renal replacement therapy (RRT), specifically in CKD stage 5. Azotemia pertains to an elevated blood urea nitrogen (BUN) level, while uremia encompasses the clinical manifestations resulting from the accumulation of nitrogenous wastes due to impaired renal function. The epidemiology of CKD reveals that over 25% of individuals aged 75 years and older have an estimated GFR (eGFR) below 60 mL/min/1.73 m², predominantly in stage 3A CKD. Clinical features of CKD can include symptoms such as restless legs syndrome, characterized by an overwhelming urge to frequently change the position of the lower limbs. When GFR falls below 15–20 mL/min/1.73 m², symptoms and signs become common and can impact virtually all body systems. 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