[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332126-105":59,"doc-detail-332126-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","circwhsc1-circnsd2-a-novel-circular-rna-in-multiple-cancers","CircWHSC1 (CircNSD2) - A Novel Circular RNA in Multiple Cancers","","Circular RNAs (circRNAs) are single-stranded non-coding RNAs with a unique circular structure generated mainly by alternative splicing of pre-mRNA. They regulate gene expression at transcriptional and post-transcriptional levels and dysregulation links them to cancer progression, acting as either tumor suppressors or oncogenes. circWHSC1 (circNSD2) originates from WHSC1 exons 1–2, is often up-regulated in multiple malignant tumors, and influences proliferation, invasion, and prognosis via miRNA sponge/ceRNA and related pathways.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circwhsc1-circnsd2-a-novel-circular-rna-in-multiple-cancers/332126/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circwhsc1-circnsd2-a-novel-circular-rna-in-multiple-cancers/332126.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are circular RNAs (circRNAs) and how are they formed?","Question",{"text":112,"@type":113},"CircRNAs are non-coding RNAs with a single-stranded circular structure, generated primarily through alternative splicing of pre-mRNA.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does circWHSC1 (circNSD2) relate to cancer?",{"text":117,"@type":113},"circWHSC1 (circNSD2) is reported to be up-regulated in multiple cancers and to affect cancer proliferation, invasion, and prognosis through regulatory pathways including miRNA sponge mechanisms.",{"name":119,"@type":110,"acceptedAnswer":120},"Which tumors are mentioned as showing circWHSC1 (circNSD2) up-regulation?",{"text":121,"@type":113},"The text lists nasopharyngeal carcinoma, lung cancer, breast cancer, liver cancer, colorectal cancer, ovarian cancer, cervical cancer, and endometrial cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332126,1790174062,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","CircWHSC1 (CircNSD2): A Novel Circular RNA in Multiple Cancers  \nXiaomin Zhang1* , Yiran Yuan1*, Xiaoxiao Wang1, Heyue Wang1, Lei Zhang2 ,3 and Jiefeng He1,2  \n1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China . 2 Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China . 3 Hepatic Surgery Center, Institute of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China .  \nClinical Medicine Insights: Oncology  \nVolume 18: 1–13  \n© The Author(s) 2024  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/11795549241254781](DOI: 10.1177/11795549241254781)  \n|  |  |\n| --- | --- |\n| ABSTRACT: Circular RNAs (circRNAs) are a type of non-coding RNA (ncRNA) that possesses a unique single-stranded circular structure. They are primarily formed through alternative splicing of pre-mRNA (messenger RNA) . The primary biological function of circRNAs is to regulate gene expression at both the transcriptional and post-transcriptional levels. Recent studies have increasingly demonstrated a close association between the dysregulation of circRNAs and the progression of diverse cancers, where they can function as either tumor suppressors oroncogenes. circWHSC1 (circNSD2) is a circular ncRNA that originates from the first 2 exons of the Wolf-Hirschhorn syndrome candidate gene (WHSC1) . As Chen 2019 discovery that circWHSC1 (circNSD2) functions as a sponge for miRNAs and promotes cancer, this circRNA has garnered significant interest among researchers. circWHSC1 (circNSD2) has been found to be up-regulated in various malignant tumors, including nasopharyngeal carcinoma, lung cancer, breast cancer, liver cancer, colorectal cancer, ovarian cancer, cervical cancer, and endometrial cancer. It exerts its effects on cancer by either inhibiting or promoting the expression of related genes through direct or indirect pathways, ultimately affecting cancer proliferation, invasion, and prognosis. This article provides a comprehensive review and discussion of the biological roles ofcircWHSC1 (circNSD2) and its target genes in various cancers, as well as the latest research progress on related molecular biological regulatory mechanisms. Furthermore, the potential significance of circWHSC1 (circNSD2) in future clinical applications and transformations is thoroughly analyzed and discussed.\u003Cbr>KeyWoRDS: CircRNA, circWHSC1 (circNSD2), miRNA sponge, ceRNA, cancers, therapy |  |\n| ReCeIVeD: November 1, 2023. ACCePTeD: April 25, 2024.\u003Cbr>TyPe: Review | CoRReSPoNDINg AuTHoRS: Jiefeng He, Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, No. 99,\u003Cbr>Longcheng Street, Taiyuan 030032, China. Email: [jfhe@sxmu.edu.cn](jfhe@sxmu.edu.cn) |\n| FuNDINg: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Shanxi Provincial Department of Human Resources and Social Security (grant number 20210001) and National Natural Science Fund (grant number 82073090) .\u003Cbr>DeClARATIoN oF CoNFlICTINg INTeReSTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. | Lei Zhang, Hepatic Surgery Center, Institute of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,\u003Cbr>Wuhan, China. Email: [zhangl7803@126.com](zhangl7803@126.com) |\n| Introduction | than 2% of the entire human genome.4 ncRNA is a class of |\n| According to the Global Cancer Statistics 2020, approximately 19.3 million new cases of cancer and nearly 10 million cancer- | RNA m","cbCaik5fLGt2jqaZ","https://ap.wps.com/l/cbCaik5fLGt2jqaZ","pdf",1209112,13,"English","# Introduction\n## Circular RNAs and cancer background","[{\"question\":\"What are circular RNAs (circRNAs) and how are they formed?\",\"answer\":\"CircRNAs are non-coding RNAs with a single-stranded circular structure, generated primarily through alternative splicing of pre-mRNA.\"},{\"question\":\"How does circWHSC1 (circNSD2) relate to cancer?\",\"answer\":\"circWHSC1 (circNSD2) is reported to be up-regulated in multiple cancers and to affect cancer proliferation, invasion, and prognosis through regulatory pathways including miRNA sponge mechanisms.\"},{\"question\":\"Which tumors are mentioned as showing circWHSC1 (circNSD2) up-regulation?\",\"answer\":\"The text lists nasopharyngeal carcinoma, lung cancer, breast cancer, liver cancer, colorectal cancer, ovarian cancer, cervical cancer, and endometrial cancer.\"}]","CircWHSC1 (CircNSD2) - A Novel Circular RNA in Multiple Cancers | PDF",1789996920,33]