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It reviews EC features and how they affect pre-menopausal physiology, then proposes miR-based molecular evaluation using a circulating miR panel for EC early diagnosis, staging, and assessment of reproductive receptivity. Ethical and legal/regulatory considerations require risk–benefit analysis, respect for autonomy, and fair access.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-mirnas-as-a-tool-for-early-diagnosis-of-endometrial-cancerimplications-for-the-fertility-sparing-process-clinical-biological-and-legal-aspects/386102/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-mirnas-as-a-tool-for-early-diagnosis-of-endometrial-cancerimplications-for-the-fertility-sparing-process-clinical-biological-and-legal-aspects/386102.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What integrated needs are addressed for EC patients who want to become pregnant?","Question",{"text":113,"@type":114},"The review considers life preservation of the woman, health preservation of the baby, minimally invasive characterization of health and fertility parameters, and the obstetric and neonatal risks as well as adult health risks for children conceived through ART.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How could circulating miRNAs support EC early diagnosis and staging?",{"text":118,"@type":114},"The article focuses on developing a miR-based molecular evaluation using a specific panel of circulating miRs to enable relatively fast, noninvasive testing with reduced margin of error for diagnosis and staging.",{"name":120,"@type":111,"acceptedAnswer":121},"Which ethical and legal/regulatory issues are emphasized for these innovative techniques?",{"text":122,"@type":114},"The review stresses that ethical/legal use requires risk–benefit analysis, respect for patient autonomy, and equitable allocation of healthcare access.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},386102,1790718885,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review  \nCirculating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects  \nRoberto Piergentili 1, Giuseppe Gullo 2, *, Giuseppe Basile 3, Caterina Gulia 4, Alessandro Porrello 5, Gaspare Cucinella 2, Enrico Marinelli 6 and Simona Zaami 7  \nCitation: Piergentili, R.; Gullo, G.; Basile, G.; Gulia, C.; Porrello, A.; Cucinella, G.; Marinelli, E.; Zaami, S. Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects. Int. J. Mol. Sci. 2023, 24, 11356. [https://](https://)[ ](https://)[doi.org/10.3390/ijms241411356](doi.org/10.3390/ijms241411356)  \nAcademic Editor: Yasuhiro Miki  \nReceived: 31 May 2023  \nRevised: 4 July 2023  \nAccepted: 10 July 2023  \nPublished: 12 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Istituto di Biologia e Patologia Molecolari del CNR (IBPM-CNR), 00185 Rome, Italy; roberto.piergentili@cnr.it  \n2 Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, IVF UNIT, University of Palermo, 90146 Palermo, Italy; [gaspare.cucinella@unipa.it](gaspare.cucinella@unipa.it)  \n3 IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy; [basiletraumaforense@gmail.com](basiletraumaforense@gmail.com)  \n4 Dipartimento di Urologia, Ospedale della Misericordia, 58100 Grosseto, Italy; [85cate@live.it](85cate@live.it)  \n[5](5 Lineberger Comprehensive Cancer Center & RNA Discovery Center)[ Lineberger Comprehensive Cancer Center & RNA Discovery Center](5 Lineberger Comprehensive Cancer Center & RNA Discovery Center), [University of North Carolina at Chapel](University of North Carolina at Chapel)[ ](University of North Carolina at Chapel)Hill, 450 West Drive, Chapel Hill, NC 27599, USA; [aporrelloresearch@yahoo.com](aporrelloresearch@yahoo.com)  \n[6](6 Department of Medico-Surgical Sciences and Biotechnologies)[ Department of Medico-Surgical Sciences and Biotechnologies](6 Department of Medico-Surgical Sciences and Biotechnologies),“Sapienza” University of Rome,  \n00161 Rome, Italy; [enrico.marinelli@uniroma1.it](enrico.marinelli@uniroma1.it)  \n7 Department of Anatomical, Histological, Forensic and Orthopedic Sciences,“Sapienza” University of Rome, 00161 Rome, Italy; [simona.zaami@uniroma1.it](simona.zaami@uniroma1.it)  \n* Correspondence: [gullogiuseppe@libero.it](gullogiuseppe@libero.it)  \nAbstract: This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally invasive characterization of the health and fertility parameters of the patient, together with the concerns regarding the obstetric, neonatal, and adult health risks of the children conceived via assisted reproductive techniques (ART) are all essential aspects of the problem tobe taken into consideration, yet the possibility to harmonize such needs through a concerted and integrated approach is still very challenging. This review aims to illustrate the main features of EC and how it affects the normal physiology of pre-menopausal women. We also focus on the prospect of a miR-based, molecular evaluation of patient health status, including both EC early diagnosis and staging and, similarly, the receptivity of the woman, discussing the possible evaluation of both aspects using a single specific panel of circulating miRs in the patient, thus allowing a relatively fast, noninvasive testing with a significantly reduced marg","cbCailfEcKEpRKwq","https://ap.wps.com/l/cbCailfEcKEpRKwq","pdf",986250,"English","# Introduction\n# Endometrial cancer and pre-menopausal epidemiology\n# Assisted reproductive technology (ART) in cancer patients\n## Impact on fertility and embryo genome\n# miR-based molecular evaluation for EC","[{\"question\":\"What integrated needs are addressed for EC patients who want to become pregnant?\",\"answer\":\"The review considers life preservation of the woman, health preservation of the baby, minimally invasive characterization of health and fertility parameters, and the obstetric and neonatal risks as well as adult health risks for children conceived through ART.\"},{\"question\":\"How could circulating miRNAs support EC early diagnosis and staging?\",\"answer\":\"The article focuses on developing a miR-based molecular evaluation using a specific panel of circulating miRs to enable relatively fast, noninvasive testing with reduced margin of error for diagnosis and staging.\"},{\"question\":\"Which ethical and legal/regulatory issues are emphasized for these innovative techniques?\",\"answer\":\"The review stresses that ethical/legal use requires risk–benefit analysis, respect for patient autonomy, and equitable allocation of healthcare access.\"}]","Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process - Clinical, Biological, and Legal Aspects | PDF",1790272257]