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This narrative review updates literature from 2018–2023 on PubMed, summarizing emerging research interests across highly studied cancers, with emphasis on breast cancer and lung cancer. The review finds over 150 related papers in five years, highlights c-miRNAs’ relevance to early detection, therapeutic resistance, recurrence risk, and new detection platforms, and notes deregulated c-miRNAs shared between breast and lung cancer, focusing on miR-21 and miR-145.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-micrornas-in-cancer-a-5-year-update-with-a-focus-on-breast-and-lung-cancers/327249/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-micrornas-in-cancer-a-5-year-update-with-a-focus-on-breast-and-lung-cancers/327249.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are circulating microRNAs and why are they important in cancer research?","Question",{"text":112,"@type":113},"Circulating microRNAs (c-miRNAs) are non-coding RNAs found in bodily fluids. They are investigated for their prognostic potential and biological role in cancer, including mechanisms involving carriers and extracellular stability.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What scope does the review cover regarding c-miRNA publications?",{"text":117,"@type":113},"The review summarizes PubMed papers published over the last five years (2018–2023) and reports that more than 150 papers focused on c-miRNAs and cancer in that period.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cancers receive primary attention and what are key application areas mentioned?",{"text":121,"@type":113},"Breast cancer and lung cancer receive primary focus due to their high global incidence. 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Circulating microRNAs in Cancer: A 5-Year Update with a Focus on Breast and Lung Cancers. Int. J. Mol. Sci. 2024, 25, 3140. [https://doi.org/10.3390/ijms](https://doi.org/10.3390/ijms)[ ](https://doi.org/10.3390/ijms)25063140  \nAcademic Editor: Rui Medeiros  \nReceived: 26 January 2024  \nRevised: 20 February 2024  \nAccepted: 7 March 2024  \nPublished: 8 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Experimental Medicine, Division of Molecular Biology, Biotechnology and Histology, University of Campania, 80138 Naples, Italy; dario.siniscalco@unicampania.it (D.S.); [umberto.galderisi@unicampania.it](umberto.galderisi@unicampania.it) (U.G.)  \n2 European Biomedical Research Institute of Salerno (EBRIS), 84125 Salerno, Italy  \n3 Research Institute on Terrestrial Ecosystems (IRET), National Research Council of Italy (CNR), Via Pietro Castellino 111, 80131 Naples, Italy; [gianfranco.peluso@unicamillus.org](gianfranco.peluso@unicamillus.org)  \n4 Faculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant’Alessandro 8, 00131 Rome, Italy  \n* [Correspondence: mauro.finicelli@cnr.it](Correspondence: mauro.finicelli@cnr.it); Tel.: +39-081-6132-553  \nAbstract: Circulating microRNAs (c-miRNAs) are non-coding RNAs found in different bodily fluidsand are highly investigated for their prognostic potential and biological role in cancer. In this narrative review, we provide an update of the last five years’ published papers (2018–2023) on PubMed about c-miRNAs in cancer research. We aim to capture the latest research interests in terms of the highly studied cancers and the insights about c-miRNAs. Our analysis revealed that more than 150 papers focusing on c-miRNAs and cancer were published in the last five years. Among these, there was a high prevalence of papers on breast cancer (BC) and lung cancer (LC), which are estimated to be the most diagnosed cancers globally. Thus, we focus on the main evidence and research trends about c-miRNAs in BC and LC. We report evidence of the effectiveness of c-miRNAs in hot topics of cancer research, such as, early detection, therapeutic resistance, recurrence risk and novel detection platform approaches. Moreover, we look at the deregulated c-miRNAs shared among BC and LC papers, focusing on miR-21 and miR-145 . Overall, these data clearly indicate that the role of c-miRNAs in cancer is still a hot topic for oncologic research and that blood is the most investigated matrix.  \nKeywords: miRNAs; breast cancer; lung cancer; immunotherapy; recurrence  \n1. Introduction  \nNon-coding RNAs (ncRNAs) encompass a large family of RNAs not encoding for a known protein but having a role in the transcription of protein-coding genes, the maturation of the transcripts and their translation into functional proteins [1–3] . Among them, the micro RNAs (miRNAs) are the most studied and characterized type. The biological role of these molecules in both physiological and pathological processes has been widely investigated, as well as their potential applications for the diagnosis and prognosis of human diseases, including cancer [2] .  \nMiRNAs are single-strand ncRNAs of approximately 22 nucleotides mainly involved in the post-transcriptional regulation of target mRNAs. They bind to the 3′ -untraslated region of mRNAs and promote their degradation and/or inhibition of translation. The interaction ","cbCailaey0I9jEIa","https://ap.wps.com/l/cbCailaey0I9jEIa","pdf",2073867,22,"English","# Abstract\n## Introduction\n## Circulating microRNAs and carriers\n## Functional roles and intercellular communication\n## Research focus on breast and lung cancers\n## Shared deregulated microRNAs","[{\"question\":\"What are circulating microRNAs and why are they important in cancer research?\",\"answer\":\"Circulating microRNAs (c-miRNAs) are non-coding RNAs found in bodily fluids. They are investigated for their prognostic potential and biological role in cancer, including mechanisms involving carriers and extracellular stability.\"},{\"question\":\"What scope does the review cover regarding c-miRNA publications?\",\"answer\":\"The review summarizes PubMed papers published over the last five years (2018–2023) and reports that more than 150 papers focused on c-miRNAs and cancer in that period.\"},{\"question\":\"Which cancers receive primary attention and what are key application areas mentioned?\",\"answer\":\"Breast cancer and lung cancer receive primary focus due to their high global incidence. The review discusses evidence for c-miRNAs in areas such as early detection, therapeutic resistance, recurrence risk, and novel detection platform approaches.\"}]","Circulating microRNAs in Cancer - A 5-Year Update with a Focus on Breast and Lung Cancers | PDF",1789976808,55]