[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331379-105":59,"doc-detail-331379-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","circulating-levels-of-cytokines-and-risk-of-urologic-cancers-a-two-sample-mendelian-randomization-study","Circulating levels of cytokines and risk of urologic cancers - a two-sample Mendelian randomization study","","Chronic inflammation is linked to cancer etiology, yet evidence on which circulating cytokines causally influence urologic cancers remains insufficient. This two-sample Mendelian randomization study uses summary-level genetic data for bladder, prostate, and kidney cancers from UK Biobank, leveraging variants associated with 41 cytokines as instrumental variables. Associations are tested with inverse-variance weighted analyses and sensitivity methods, while heterogeneity, pleiotropic outliers, genetic correlation, colocalization, and multivariable MR assess validity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-levels-of-cytokines-and-risk-of-urologic-cancers-a-two-sample-mendelian-randomization-study/331379/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-levels-of-cytokines-and-risk-of-urologic-cancers-a-two-sample-mendelian-randomization-study/331379.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the goal of the two-sample Mendelian randomization study?","Question",{"text":113,"@type":114},"To evaluate the role of circulating cytokines in the development of urologic cancers using a two-sample MR approach.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancers are analyzed and where does the genetic data come from?",{"text":118,"@type":114},"Bladder, prostate, and kidney cancer are analyzed using summary-level data from UK Biobank.",{"name":120,"@type":111,"acceptedAnswer":121},"What key cytokine associations were reported after multiple testing correction?",{"text":122,"@type":114},"Elevated genetically predicted CCL27 was associated with higher bladder cancer risk, while IL-12p70 showed a protective association.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331379,1790185132,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Song et al. BMC Cancer (2024) 24:1261 [https://doi.org/10.1186/s12885-024-13016-9](https://doi.org/10.1186/s12885-024-13016-9)  \nBMC Cancer  \n RESEARCH Open Access  \nCirculating levels of cytokines and risk of urologic cancers: a two-sample Mendelian randomization study  \nJinbo Song1*, Xiaoke Sun1, Ting Wang1, Chao Li1 and Leihong Yuan1  \nAbstract  \nBackground Chronic inflammation is associated with the etiology of various cancers. However, there is a lack of systematic research in urologic cancers. This study aims to use a two-sample Mendelian randomization (MR) approach to evaluate the role of circulating cytokines in the development of urologic cancers.  \nMethods We obtained the summary-level data for bladder cancer (373,295 cases and 372,016 controls), prostate cancer (462,933 cases and 459,664 controls), and kidney cancer (463,010 cases and 461,896 controls) from the UK Biobank. Genetic variations linked to 41 circulating cytokines were used as instrumental variables (IVs) in metaanalyses of genome-wide association studies (GWASs) involving 8,293 individuals from Finland. We primarily  \nused the inverse-variance weighted (IVW) method to assess the potential associations between the 41 cytokines and the risk of 3 common urologic cancers. Weighted-median method, weighted mode and simple-median method were used to assess the sensitivity. Heterogeneity and pleiotropic outlier were evaluated by Cochran’s Q test and MREgger regression. Genetic correlation, colocalization analysis and multivariable MR analysis were used to further validate the potential pleiotropy.  \nResults After the Bonferroni correction, there was an observed association between elevated genetically predicted levels of CCL27 and a heightened risk for bladder cancer. Conversely, IL-12p70 levels were found to have a protective association against the risk of bladder cancer. Sensitivity analyses utilizing various IV sets and MR approach remained robust. Furthermore, we found potential associations of 7 cytokines with urologic cancers (4 .07 × 10−4 ≤ P \u003C 0. 05) . Conclusion Our study supported causal associations between CCL27, IL-12p70 and bladder cancer risk and potential associations of 7 cytokines with the risk of urologic cancers, helping us to further understand the pathogenesis of urologic cancers and providing clues for improving diagnostic accuracy and therapies.  \nKeywords Mendelian randomization, Urologic cancers, Inflammation, Cytokines, Single nucleotide polymorphisms  \n*Correspondence: Jinbo Song [songjb0517@163.com](songjb0517@163.com)  \n1 Department of Urology Surgery, Honghui Hospital, Xi’an Jiaotong University, Beilin District, Xi’an, Shaanxi Province 710000, China  \nIntroduction  \nUrologic cancers encompass a group of malignancies that affect various parts of urinary system, mainly including prostate, bladder, and kidney cancer. These cancers pose significant health burdens globally and are associated with a high morbidity and mortality rate [1]. Over the years, extensive research has focused on identifying risk factors and potential mechanisms underlying urologic cancers. Studies have shown that age, body mass index,  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statut","cbCaih16Xgwm5eHv","https://ap.wps.com/l/cbCaih16Xgwm5eHv","pdf",1353160,12,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the goal of the two-sample Mendelian randomization study?\",\"answer\":\"To evaluate the role of circulating cytokines in the development of urologic cancers using a two-sample MR approach.\"},{\"question\":\"Which cancers are analyzed and where does the genetic data come from?\",\"answer\":\"Bladder, prostate, and kidney cancer are analyzed using summary-level data from UK Biobank.\"},{\"question\":\"What key cytokine associations were reported after multiple testing correction?\",\"answer\":\"Elevated genetically predicted CCL27 was associated with higher bladder cancer risk, while IL-12p70 showed a protective association.\"}]","Circulating levels of cytokines and risk of urologic cancers - a two-sample Mendelian randomization study | PDF",1789993048]