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Methods: Incident lung cancer cases (n=192) and matched controls (n=192) from the CLUE I and II cohorts were studied using archived 1974 serum. Immunoblotting quantified IgG antibodies to 13 periodontium-associated bacteria, and associations were estimated with conditional logistic regression. Results: Most measured antibodies were inversely associated with lung cancer, with three significant protective associations; one Porphyromonas gingivalis strain showed a positive association after adjustment. Conclusions: Results indicate complex relationships between serum IgG to oral pathogens and later lung cancer risk.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-igg-antibodies-to-periodontal-bacteria-and-lung-cancer-risk-in-the-clue-cohorts/377804/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-igg-antibodies-to-periodontal-bacteria-and-lung-cancer-risk-in-the-clue-cohorts/377804.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the study’s main purpose regarding periodontitis and lung cancer?","Question",{"text":113,"@type":114},"To examine whether serum IgG antibody levels to specific periodontal bacteria are associated with later lung cancer risk in the CLUE cohorts.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were participants and antibody measurements selected and performed?",{"text":118,"@type":114},"Incident lung cancer cases and matched controls were selected from CLUE I and II, using archived 1974 serum. IgG antibodies against 13 periodontal bacteria were measured by immunoblotting.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings about antibody–lung cancer associations?",{"text":122,"@type":114},"Most periodontal bacterial antibodies showed inverse associations with lung cancer risk, including three statistically significant antibodies. One P. gingivalis strain was positively associated after adjustment, and the combined log-sum measure related inversely to risk in longer follow-up.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377804,1791047042,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","JNCI Cancer Spectrum, 2023, 7(3), pkad029  \n[https://doi.org/10.1093/jncics/pkad029](https://doi.org/10.1093/jncics/pkad029)  \nAdvance Access Publication Date: April 11, 2023 Article  \nCirculating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts  \nNana K. Ampomah, MPH,1 Flavia Teles, DDS,2 Lynn M. Martin, BS,2 Jiayun Lu, PhD,3 Devin C. Koestler, PhD,4,5 Karl T. Kelsey , MD,6,7 James D. Beck, PhD,8 Elizabeth A. Platz , ScD,3,9 Dominique S. Michaud , ScD1,6,*  \n1Department of Public Health and Community Medicine, Tufts University School of Medicine, Tufts University, Boston, MA, USA  \n2Department of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA, USA 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 4Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA 5University of Kansas Cancer Center, Kansas City, KS, USA  \n6Department of Epidemiology, Brown University, Providence, RI, USA  \n7Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA  \n8Division of Comprehensive Oral Health/Periodontology, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA 9The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA  \n*Correspondence to: Dominique S. Michaud, ScD, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA (e-mail:  \n[dominique.michaud@tufts.edu](dominique.michaud@tufts.edu)) .  \nAbstract  \nBackground: Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers.  \nMethods: Incident lung cancer cases (n ¼ 192) and matched controls (n ¼ 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression.  \nResults: Most of the periodontal bacterial antibodies measured were inversely associated with lung cancer risk; of these, 3 were statistically significant (Prevotella intermedia, Actinomyces naeslundii, and Veillonella parvula) . A statistically significant positive association was observed for one of the Porphyromonas gingivalis strains after adjusting for P. intermedia. The sum of the logarithm of antibodies against the 13 measured bacteria was inversely associated with risk of lung cancer when the analysis was restricted to a longer follow-up (31-44years after blood collection, highest vs lowest quartile: odds ratio ¼ 0.26, 95% confidence interval ¼ 0.08 to 0.84) . Conclusions: Findings from this study highlight the complexity of using serum IgG antibodies to periodontal bacteria to identify associations between oral pathogens and risk oflung cancer. The inverse associations observed for antibodies to periodontal bacteria suggest that these may represent markers of immunity that provide some advantage in reducing the development of lung cancer.  \nOver the past decade, a number of studies have provided new evidence suggesting that poor oral health plays a role in generating risk for various cancers, including lung, oropharyngeal, colorectal, and pancreatic (1 ,2) . In 2019, a meta-analysis reported that 5 out of 7 studies identified a statistically significant increase in risk of lung cancer among those with a history of periodontitis (2) . The indirect mechanisms for a link between periodontitis and cancer have been attributed to the known associations between systemic inflammation and immune dysregulation, and cancer (3 ,4) .  \nSerum immunoglobulin G (IgG) antib","cbCaiqE8AuL8YcJD","https://ap.wps.com/l/cbCaiqE8AuL8YcJD","pdf",320118,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is the study’s main purpose regarding periodontitis and lung cancer?\",\"answer\":\"To examine whether serum IgG antibody levels to specific periodontal bacteria are associated with later lung cancer risk in the CLUE cohorts.\"},{\"question\":\"How were participants and antibody measurements selected and performed?\",\"answer\":\"Incident lung cancer cases and matched controls were selected from CLUE I and II, using archived 1974 serum. IgG antibodies against 13 periodontal bacteria were measured by immunoblotting.\"},{\"question\":\"What were the key findings about antibody–lung cancer associations?\",\"answer\":\"Most periodontal bacterial antibodies showed inverse associations with lung cancer risk, including three statistically significant antibodies. One P. gingivalis strain was positively associated after adjustment, and the combined log-sum measure related inversely to risk in longer follow-up.\"}]","Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts | PDF",1790227216]