[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380797-105":59,"doc-detail-380797-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","circulating-histones-to-detect-and-monitor-the-progression-of-cancer","Circulating Histones to Detect and Monitor the Progression of Cancer","","Liquid biopsies provide a minimally invasive way to detect and track cancer-related changes in nucleosomes or histones using blood, saliva, and urine. Histones are central to nucleosome structure and chromatin-dependent gene regulation, and accumulating evidence indicates that circulating histones and histone complexes—released through cell death or immune activation—can function as biomarkers. This review summarizes detection strategies and key findings across hematologic malignancies and solid tumors, emphasizing dissemination, monitoring, and tumorigenesis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-histones-to-detect-and-monitor-the-progression-of-cancer/380797/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-histones-to-detect-and-monitor-the-progression-of-cancer/380797.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are circulating histones and why are they useful for cancer detection?","Question",{"text":112,"@type":113},"Circulating histones are histone proteins or histone complexes present in body fluids. They can reflect cancer-related alterations originating from cell death or immune activation, making them potential biomarkers for detection and management.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does liquid biopsy support cancer monitoring?",{"text":117,"@type":113},"Liquid biopsy enables minimally invasive molecular diagnosis and provides information about tumor molecular landscapes. It can track progression and support decisions such as therapy guidance and minimal residual disease detection.",{"name":119,"@type":110,"acceptedAnswer":120},"What detection approaches are covered for circulating histones?",{"text":121,"@type":113},"The review outlines strategies to detect circulating histones and histone complexes, and it highlights methods to identify cancer tissue-of-origin from blood plasma using nucleosome positioning inferred from nucleosomal DNA fragmentation patterns.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380797,1790613649,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nCirculating Histones to Detect and Monitor the Progression of Cancer  \nDesislava K. Tsoneva 1,2, Martin N. Ivanov 2,3, Nikolay Vladimirov Conev 4,5, Rostislav Manev 4,5, Dragomir Svetozarov Stoyanov 4,5 and Manlio Vinciguerra 2, *  \nCitation: Tsoneva, D.K.; Ivanov, M.N.; Conev, N.V.; Manev, R.; Stoyanov, D.S.; Vinciguerra, M. Circulating Histones to Detect and Monitor the Progression of Cancer. Int. J. Mol. Sci. 2023, 24, 942 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms24020942  \nAcademic Editors: Sandra V. Fernandez and Carmela Paolillo  \nReceived: 12 December 2022  \nRevised: 26 December 2022  \nAccepted: 29 December 2022  \nPublished: 4 January 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medical Genetics, Faculty of Medicine, Medical University of Varna, 9000 Varna, Bulgaria  \n2 Department of Stem Cell Biology and Transplantology, Research Institute, Medical University of Varna, 9000 Varna, Bulgaria  \n3 Department of Anatomy and Cell Biology, Research Institute, Medical University of Varna, 9000 Varna, Bulgaria  \n4 Clinic of Medical Oncology, UMHAT “St. Marina”, 1 “Hristo Smirnenski” Blvd., 9000 Varna, Bulgaria  \n5 Department of Propedeutics of Internal Diseases, Medical University of Varna, 9000 Varna, Bulgaria  \n* [Correspondence: manlio.vinciguerra@mu-varna.bg](Correspondence: manlio.vinciguerra@mu-varna.bg)  \nAbstract: Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring method, which could identify cancer-related alterations in nucleosome or histone levels and modifications in blood, saliva, and urine. Histones, the core component of the nucleosome, are essential for chromatin compaction and gene expression modulation. Increasing evidence suggests that circulating histones and histone complexes, originating from cell death or immune cell activation, could act as promising biomarkers for cancer detection and management. In this review, we provide an overview of circulating histones as a powerful liquid biopsy approach and methods for their detection. We highlight current knowledge on circulating histones in hematologic malignancies and solid cancer, with a focus on their role in cancer dissemination, monitoring, and tumorigenesis. Last, we describe recently developed strategies to identify cancer tissue-of-origin in blood plasma based on nucleosome positioning, inferred from nucleosomal DNA fragmentation footprint, which is independent of the genetic landscape.  \nKeywords: liquid biopsy; histones; cell-free DNA; cancer  \n1. Introduction  \n1.1. Liquid Biopsy  \nLiquid biopsy represents a minimally invasive, convenient, and cost-effective method for molecular diagnosis. It is increasingly recognized that liquid biopsy can provide comprehensive information on the molecular landscapes of cancer. Methods for isolation and analysis of liquid biopsies have rapidly improved over the past few years, providing greater insights into tumor characteristics such as progression, staging, heterogeneity, gene mutations and clonal evolution. Although the technology of liquid biopsies is still developing, its non-invasive nature promises to open new scenarios in clinical oncology. Liquid biopsies include circulating tumor DNA (ctDNA), circulating tumor cells (CTC), tumor extracellular vesicles (TEV), and circulating histones and histone complexes (Figure 1) .  \nCirculating tumor DNA liquid biopsy has been studied most extensively in patients with established metastatic disease and has been applied in some routine clinical applications using next-generation sequencing (NGS) technologies [1,2] . Very often, tumors are characterize","cbCairj9as8oil07","https://ap.wps.com/l/cbCairj9as8oil07","pdf",881274,22,"English","# Abstract\n# Introduction\n## Liquid Biopsy","[{\"question\":\"What are circulating histones and why are they useful for cancer detection?\",\"answer\":\"Circulating histones are histone proteins or histone complexes present in body fluids. They can reflect cancer-related alterations originating from cell death or immune activation, making them potential biomarkers for detection and management.\"},{\"question\":\"How does liquid biopsy support cancer monitoring?\",\"answer\":\"Liquid biopsy enables minimally invasive molecular diagnosis and provides information about tumor molecular landscapes. It can track progression and support decisions such as therapy guidance and minimal residual disease detection.\"},{\"question\":\"What detection approaches are covered for circulating histones?\",\"answer\":\"The review outlines strategies to detect circulating histones and histone complexes, and it highlights methods to identify cancer tissue-of-origin from blood plasma using nucleosome positioning inferred from nucleosomal DNA fragmentation patterns.\"}]","Circulating Histones to Detect and Monitor the Progression of Cancer | PDF",1790242170,55]