[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-468852-105":59,"doc-detail-468852-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","circulating-endocannabinoids-and-cognitive-function-in-older-adults","Circulating endocannabinoids and cognitive function in older adults","","Endogenous cannabinoids (endocannabinoids; eCBs) are lipid signaling molecules involved in neuromodulation and neuroinflammation. Evidence from preclinical work links eCBs to cognitive processes, yet human observational data remain constrained, especially when focusing on only a few “classical” eCB compounds. This study examined how multiple circulating eCBs and eCB-like molecules relate to cognitive function in dementia-free older adults, testing modification by sex and ApoEε4 genotype.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circulating-endocannabinoids-and-cognitive-function-in-older-adults/468852/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circulating-endocannabinoids-and-cognitive-function-in-older-adults/468852.png","ImageObject",300,407,{"name":92,"@type":93},"Chumphorn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study aim regarding endocannabinoids and cognition?","Question",{"text":112,"@type":113},"To assess the relationship between multiple circulating eCBs/eCB-like molecules and cognitive function in dementia-free older adults, including whether effects differed by sex and ApoEε4 genotype.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were endocannabinoids measured and which participants were analyzed?",{"text":117,"@type":113},"Serum levels of 44 eCBs were analyzed in cognitively healthy participants aged 65+ from the Framingham Heart Study Offspring cohort, at examination cycle 9 (2011–2014).",{"name":119,"@type":110,"acceptedAnswer":120},"Which eCB-related compounds were associated with worse cognitive outcomes?",{"text":121,"@type":113},"After correction for multiple comparisons, higher levels of linoleic acid, linolenic acid, oleic acid, oleoyl alanine, and palmitoyl alanine related to poorer executive function; linolenoyl amide and linoleoyl amide related to poorer verbal memory and attention.",{"name":123,"@type":110,"acceptedAnswer":124},"What did the study find about sex and ApoEε4-specific effects?",{"text":125,"@type":113},"A significant interaction with sex showed many associations were present mainly among women, and several eCB associations with perceptual organization were observed only among ApoEε4 carriers.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},468852,1790774761,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":133,"read_time":24,"preview_page_count":4},2336475401981,"https://ap-avatar.wpscdn.com/avatar/22000c94efd8d5204d?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786935347598174694","DOI: 10. 1002/alz70856_105642  \nBIOMARKERS  \nPOSTER PRESENTATION  \nBIOMARKERS (NON-NEUROIMAGING)  \nCirculating endocannabinoids and cognitive function in older adults  \nShiraz Vered 1  Alexa S Beiser2, 3, 4, 5, 6, 7 Saptaparni Ghosh4, 5  Gil M Lewitus8  \n Liron Sulimani8  Sharon Sznitman9  David Meiri (Dedi)8   \nSudha Seshadri 10, 11, 12, 13, 14  Galit Weinstein1  \n1School of Public Health, University of Haifa, Haifa, Mount Carmel, Israel  \n2 Boston University School of Public Health, Boston, MA, USA  \n3 Boston University School of Medicine, Boston, MA, USA  \n4The Framingham Heart Study, Framingham, MA, USA  \n5 Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA  \n6 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA  \n7 Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA  \n8Technion-Israel Institute of Technology, Haifa, Israel  \n9 University of Haifa, Haifa, Israel  \n10 Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA  \n11 Department of Neurology, Boston University School of Medicine, Boston, MA, USA  \n12 Framingham Heart Study, Framingham, Boston, MA, USA  \n13 Department of Neurology, University of Texas Health Sciences Center, San Antonio, TX, USA, San Antonio, TX, USA  \n14 University of Texas Health San Antonio, San Antonio, TX, USA  \nCorrespondence  \nGalit Weinstein, School of Public Health, University of Haifa, Haifa, Mount Carmel, Israel.  \nAbstract  \nBackground: Endogenous cannabinoids (endocannabinoids; eCBs) are small lipophilic signaling molecules implicated in multiple functions including neuromodulation and neuroinflammation. While the role of eCBs in cognitive-related processes has been demonstrated in preclinical studies, observational studies are limited, particularly by exploration of only few ‘classical’ eCB compounds. We assessed the relationship of multiple circulating eCBs and eCB-like molecules with cognitive function, and tested for effect-modification by sex and apolipoprotein ɛ4 (ApoEɛ4) genotype in a sample of dementia-free older adults.  \nMethod: In this cross-sectional study, serum levels of 44 eCBs were analyzed in cognitively healthy participants aged ≥65 years of the Framingham Heart Study Offspring cohort who attended examination cycle 9 (2011-2014). Linear regression models were used to examine the associations of eCB serum levels with cognitive function while adjusting for potential confounders including age, sex, education, ApoEɛ4, obesity and time between the eCB measurement and cognitive assessment. Effect modification by sex and ApoEɛ4 was additionally examined by including interactions terms in the models and stratification.  \nResult: A total of 237 participants were included (mean age 73.3±6. 2 years and 95 (40%) men). After correction for multiple comparisons, increased levels of linoleic acid, linolenic acid, oleic acid, oleoyl alanine and palmitoyl alanine were associated with poorer executive function (B±SE=-0.0002±0.0001, p = 0.002; B±SE=-0.0005±0.0001, p \u003C0.001; B±SE=-0.0002±0.0001, p = 0.003; B±SE=-0.74±0. 25, p = 0.003 and B±SE=-1.75±0. 62, p = 0.005, respectively). In addition, elevated levels of linolenoyl amide and linoleoyl amide were associated with poorer verbal memory (B±SE= - 1.45±0.44, p = 0.001 and B±SE=-0.16±0.05, p \u003C0.001, respectively) and attention (B±SE=-0.12±0.04, p \u003C0.001 and B±SE=-0.013±0.004, p \u003C0.001, respectively). A  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105642.  \n[https://doi.org/10.1002/alz70856_105642](https://doi.org/10.1002/alz708","cbCaimgsEjgSvhqj","https://ap.wps.com/l/cbCaimgsEjgSvhqj","pdf",101371,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What was the study aim regarding endocannabinoids and cognition?\",\"answer\":\"To assess the relationship between multiple circulating eCBs/eCB-like molecules and cognitive function in dementia-free older adults, including whether effects differed by sex and ApoEε4 genotype.\"},{\"question\":\"How were endocannabinoids measured and which participants were analyzed?\",\"answer\":\"Serum levels of 44 eCBs were analyzed in cognitively healthy participants aged 65+ from the Framingham Heart Study Offspring cohort, at examination cycle 9 (2011–2014).\"},{\"question\":\"Which eCB-related compounds were associated with worse cognitive outcomes?\",\"answer\":\"After correction for multiple comparisons, higher levels of linoleic acid, linolenic acid, oleic acid, oleoyl alanine, and palmitoyl alanine related to poorer executive function; linolenoyl amide and linoleoyl amide related to poorer verbal memory and attention.\"},{\"question\":\"What did the study find about sex and ApoEε4-specific effects?\",\"answer\":\"A significant interaction with sex showed many associations were present mainly among women, and several eCB associations with perceptual organization were observed only among ApoEε4 carriers.\"}]","Circulating endocannabinoids and cognitive function in older adults | PDF"]