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Pine,  \nUniversity of Colorado, United States  \nREVIEWED BY  \nHui Wang,  \nUniversity of California, Los Angeles, United States  \nHongran Qin,  \nMayo Clinic, United States  \n*CORRESPONDENCE  \nWenlong Wang  \n[wwlkqwk@163.com](wwlkqwk@163.com)[ ](wwlkqwk@163.com)Xiangrui Ma  \n [maxiang851225@bzmc.edu.cn](maxiang851225@bzmc.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 18 September 2024  \nACCEPTED 13 November 2024  \nPUBLISHED 03 December 2024  \nCITATION  \nTang J, Yu D, Song J, Li J, Zhang Y, Ma X and Wang W (2024) CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z. Front. Oncol. 14:1498139 .  \ndoi: 10.3389/fonc.2024.1498139  \nCOPYRIGHT  \n© 2024 Tang, Yu, Song, Li, Zhang, Ma and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z  \nJuan Tang1,2†, Donglin Yu1,2†, Jiaojiao Song 3, Junfei Li 1,2, Yijuan Zhang 4, Xiangrui Ma 1,2* and Wenlong Wang 1,2*  \n1 Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, China, 2School of Stomatology, Binzhou Medical University, Yantai, China, 3 Plantation Center, Weihai Stomatological Hospital, Weihai, China, 4 Department of Anesthesiology, Binzhou Medical University Hospital, Binzhou, China  \nIntroduction: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3- 3z) is central to various signalling pathways and is pivotal in tumour progression.  \nMethods: Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.  \nResults: The study found that CircRNA_ 036186 regulates the expression of 14- 3-3z in HNSCC through miR-193b-5p.  \nDiscussion: These findings suggest that CircRNA_ 036186 has the potential to bea biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.  \nKEYWORDS  \nhead and neck squamous cell carcinoma, bioinformatics analysis, high throughput sequencing technology, CircRNA, MiRNA, 14-3-3z  \nIntroduction  \nHead and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. The presence of numerous essential structures, including muscles, bones, blood vessels, and nerves, in the head and neck area presents a significant challenge to eradicating the disease using conventional  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nmethods, such as surgery, chemotherapy, and radiotherapy. Patients with HNSCC experience a notable decline in their quality of life and mental health (1, 2) . Consequently, identifying novel potential biomarkers is paramount for diagnosing, treating, and predicting outcomes in patients with HNSCC.  \nThe 14-3-3 protein is a highly conserved family of molecules. Tissues demonstrate independent subtype-specific functions with seven distinct subtypes (b, g, e, h, s, q, and z), each of which is localised in tissues with independent subtype-specific functions (3) . The tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3z or YWHAZ) is a member of the 1","cbCaiqn3ZZoODcSg","https://ap.wps.com/l/cbCaiqn3ZZoODcSg","pdf",5568916,12,"English","# Introduction\n## HNSCC background and need for biomarkers\n## Roles of 14-3-3 family and 14-3-3z\n## Functions of miRNA and circRNA\n## Study aim\n# Methods\n## Patient tissue collection and sequencing\n## Prediction of circRNA–miRNA–mRNA interactions\n# Results\n## Elevated 14-3-3z expression in HNSCC\n# Discussion","[{\"question\":\"What is the study’s main focus in HNSCC?\",\"answer\":\"The study focuses on how circRNA contributes to HNSCC progression by regulating 14-3-3z.\"},{\"question\":\"How was CircRNA_ 036186 linked to 14-3-3z?\",\"answer\":\"The work used high-throughput sequencing and bioinformatics prediction, finding that CircRNA_ 036186 regulates 14-3-3z via miR-193b-5p.\"},{\"question\":\"Why is identifying biomarkers important for HNSCC patients?\",\"answer\":\"HNSCC has a poor prognosis and affects patients’ quality of life and mental health, so novel biomarkers are needed for diagnosis, treatment planning, and outcome prediction.\"}]","CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z | PDF",1789994420]