[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339781-105":59,"doc-detail-339781-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","circadian-rhythm-disruption-and-endocrine-related-tumors-review","Circadian rhythm disruption and endocrine-related tumors - Review","","This review delves into the intricate relationship between circadian clocks and physiological processes, emphasizing their role in maintaining homeostasis. Interlocked clock genes orchestrate circadian timekeeping, regulating sleep-wake behavior, energy metabolism, immune function, and cell proliferation, with synchronization driven by light-dark cues and peripheral clocks shaped by feeding times. Circadian disruption from modern lifestyle factors such as night shift work is linked to metabolic syndrome, cardiovascular disease, infections, and cancer. The review highlights mechanisms by which circadian clock genes influence metabolic disorders and cancer pathogenesis, with specific associations across multiple endocrine tumors. Evidence supports circadian rhythm-focused therapies, especially chronotherapy, and calls for further research into mechanisms and public health interventions to reduce lifestyle-related circadian disruption.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circadian-rhythm-disruption-and-endocrine-related-tumors-review/339781/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circadian-rhythm-disruption-and-endocrine-related-tumors-review/339781.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How do circadian clocks regulate physiological processes?","Question",{"text":113,"@type":114},"Interlocked clock genes orchestrate circadian timekeeping, regulating core functions such as the sleep-wake cycle, energy metabolism, immune function, and cell proliferation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What health outcomes are associated with circadian disruption?",{"text":118,"@type":114},"Circadian disruption linked to factors like night shift work correlates with adverse outcomes including metabolic syndrome, cardiovascular diseases, infections, and cancer.",{"name":120,"@type":111,"acceptedAnswer":121},"What endocrine tumors does the review highlight and why?",{"text":122,"@type":114},"The review highlights associations between circadian disruption and endocrine-related tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, and adrenal gland cancers, with gene-linked effects on progression and treatment response.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},339781,1790632744,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2024 July 24; 15(7): 818-834  \nDOI: 10.5306/wjco.v15.i7.818 ISSN 2218-4333 (online)  \nREVIEW  \nCircadian rhythm disruption and endocrine-related tumors  \nChristos Savvidis, Efthymia Kallistrou, Eleni Kouroglou, Sofia Dionysopoulou, Georgios Gavriiloglou, Dimitra Ragia, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Liu TF  \nReceived: December 30, 2023  \nRevised: June 20, 2024  \nAccepted: June 27, 2024  \nPublished online: July 24, 2024  \nProcessing time: 198 Days and 13.1 Hours  \nChristos Savvidis, Efthymia Kallistrou, Eleni Kouroglou, Sofia Dionysopoulou, Georgios Gavriiloglou, Dimitra Ragia, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias,  \nDepartment of Endocrinology, Hippocration General Hospital, Athens GR-11527, Greece Co-first authors: Christos Savvidis and Efthymia Kallistrou.  \nCorresponding author: Ioannis Ilias, MD, PhD, Director, Department of Endocrinology, Hippocration General Hospital, 63 Evrou Str, Athens GR-11527, [Greece.](Greece. iiliasmd@yahoo.com)[ iiliasmd@yahoo.com](Greece. iiliasmd@yahoo.com)  \nAbstract  \nThis review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle, energy metabolism, immune function, and cell proliferation. The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue clocks are influenced by cues such as feeding times. Circadian disruption, linked to modern lifestyle factors like night shift work, correlates with adverse health outcomes, including metabolic syndrome, cardiovascular diseases, infections, and cancer. We explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer pathogenesis. Specific associations between circadian disruption and endocrine tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, and adrenal gland cancers, are highlighted. Shift work is associated with increased breast cancer risk, with PER genes influencing tumor progression and drug resistance. CLOCK gene expression correlates with cisplatin resistance in ovarian cancer, while factors like aging and intermittent fasting affect prostate cancer. Our review underscored the intricate interplay between circadian rhythms and cancer, involving the regulation of the cell cycle, DNA repair, metabolism, immune function, and the tumor microenvironment. We advocated for integrating biological timing into clinical considerations for personalized healthcare, proposing that understanding these connections could lead to novel therapeutic approaches. Evidence supports circadian rhythm-focused therapies, particularly chronotherapy, for treating endocrine tumors. Our review called for further research to uncover detailed connections between circadian clocks and cancer, providing essential insights for targeted treatments. We emphasized the importance of public health interventions to mitigate lifestyle-related circadian disruptions and underscored the critical role of circadian rhythms in disease mechanisms and therapeutic interventions.  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 818 July 24, 2024  Volume 15  Issue 7   \nSavvidis C et al. Circadian disruption and endocrine tumors  \nKey Words: Circadian rhythm; Circ","cbCaidPgU6wW7Otq","https://ap.wps.com/l/cbCaidPgU6wW7Otq","pdf",993856,18,"English","# Abstract\n## Circadian clocks and physiological regulation\n## Impact of circadian disruption on health and cancer\n## Endocrine tumors and molecular mechanisms\n## Therapeutic implications and chronotherapy","[{\"question\":\"How do circadian clocks regulate physiological processes?\",\"answer\":\"Interlocked clock genes orchestrate circadian timekeeping, regulating core functions such as the sleep-wake cycle, energy metabolism, immune function, and cell proliferation.\"},{\"question\":\"What health outcomes are associated with circadian disruption?\",\"answer\":\"Circadian disruption linked to factors like night shift work correlates with adverse outcomes including metabolic syndrome, cardiovascular diseases, infections, and cancer.\"},{\"question\":\"What endocrine tumors does the review highlight and why?\",\"answer\":\"The review highlights associations between circadian disruption and endocrine-related tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, and adrenal gland cancers, with gene-linked effects on progression and treatment response.\"}]","Circadian rhythm disruption and endocrine-related tumors - Review | PDF",1790032150,45]