[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-428062-105":59,"doc-detail-428062-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","circadian-restactivity-rhythms-and-mri-derived-measures-of-brain-health-in-older-adults","CIRCADIAN REST/ACTIVITY RHYTHMS AND MRI-DERIVED MEASURES OF BRAIN HEALTH IN OLDER ADULTS","","Altered circadian rest/activity rhythms (RARs) measured by accelerometers have been linked to dementia risk, yet their relationship with MRI-based brain health remains uncertain. This cross-sectional study examined 396 cognitively unimpaired ARIC participants who wore a Zio XT ECG monitor with an accelerometer for 13 days and underwent 3T MRI. After adjustments, higher rhythm strength (RA) related to larger frontal, temporal, and parietal volumes and smaller WMH volume, with reduced microbleed odds, while fragmentation and stability showed limited associations. Results suggest fragmented or weaker RARs may indicate poorer brain health; prospective work is needed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/circadian-restactivity-rhythms-and-mri-derived-measures-of-brain-health-in-older-adults/428062/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/circadian-restactivity-rhythms-and-mri-derived-measures-of-brain-health-in-older-adults/428062.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were circadian rest/activity rhythms (RARs) measured in the study?","Question",{"text":112,"@type":113},"RARs were derived from accelerometer data recorded by a Zio XT ECG monitor worn for about 13 days.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What MRI-derived outcomes were analyzed?",{"text":117,"@type":113},"The study assessed brain volumes, white-matter hyperintensity (WMH) volume, and the presence of infarcts and microbleeds.",{"name":119,"@type":110,"acceptedAnswer":120},"What main association was found between rhythm strength and brain health?",{"text":121,"@type":113},"Each SD increase in rhythm strength (RA) was associated with greater frontal, temporal, and parietal lobe volume, greater total brain volume, smaller WMH volume, and lower odds of microbleeds.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},428062,1790765912,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","570 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1955  \nCIRCADIAN REST/ACTIVITY RHYTHMS AND MRI-DERIVED MEASURES OF BRAIN HEALTH IN OLDER ADULTS  \nAdam Spira1, Lacey Etzkorn1, Amal Wanigatunga1,  \nWendy Wang2, Bruce Wasserman3, Daniel Callow4, Jennifer Schrack1, and Lin Yee Chen5, 1. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States, 2. UT Southwestern Medical Center, Dallas, Texas, United States, 3. University of Maryland School of Medicine, Baltimore, Maryland, United States, 4. Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 5. University of Minnesota School of Medicine, Minneapolis, Minnesota, United States  \nAltered circadian rest/activity rhythms (RARs), measured by accelerometers, have been linked to dementia risk, but associations with neuroimaging measures of brain health remain unclear. We studied cross-sectional associations of RARs with magnetic resonance imaging (MRI) measures of brain volumes, white-matter hyperintensity (WMH) volume, and the presence of infarcts and microbleeds in 396 cognitively unimpaired Atherosclerosis Risk in Communities Study participants (mean±SD age = 78.9±4.6; 57.1% women; 28.0% Black) who wore the Zio XT ECG monitor (containing an accelerometer) for 13.0±2.1 days at Visit 6 (2016-17) and had 3-Tesla MRI scansat Visit 6 or 7 (2016-19) . RAR indices of rhythm strength (relative amplitude; RA), fragmentation (intradaily variability; IV), and day-to-day stability (interdaily stability; IS) were derived from accelerometer data. After adjustment for demographic and clinical characteristics, ApoE e4 allele carriage, and intracranial volume, each SD increase in RA was associated with 1.0% greater frontal, temporal, and parietal lobe volume, 0.9% greater total brain volume, a 13.4% smaller WMH volume, and a 28.2% lower odds of microbleeds (all p \u003C 0.05); RA was not, however, associated with odds of an infarct (p = 0.4) . In addition, higher IV was associated with lower frontal lobe volume across models (p \u003C 0.05), but it was not associated with other outcomes in fully adjusted models. There were no significant associations of IS with MRI variables. Findings support links of weaker and more  \nInnovation in Aging, 2025, Vol. 9, No. S2 571  \nfragmented RARs with poorer brain health in cognitively unimpaired older adults. Prospective studies are needed to further evaluate the potential for a causal link.","cbCaid6xoUXQPh1b","https://ap.wps.com/l/cbCaid6xoUXQPh1b","pdf",1037452,"English","# Abstract\n## Study population and measurements\n## Associations with MRI outcomes\n## Key findings and implications","[{\"question\":\"How were circadian rest/activity rhythms (RARs) measured in the study?\",\"answer\":\"RARs were derived from accelerometer data recorded by a Zio XT ECG monitor worn for about 13 days.\"},{\"question\":\"What MRI-derived outcomes were analyzed?\",\"answer\":\"The study assessed brain volumes, white-matter hyperintensity (WMH) volume, and the presence of infarcts and microbleeds.\"},{\"question\":\"What main association was found between rhythm strength and brain health?\",\"answer\":\"Each SD increase in rhythm strength (RA) was associated with greater frontal, temporal, and parietal lobe volume, greater total brain volume, smaller WMH volume, and lower odds of microbleeds.\"}]","CIRCADIAN REST/ACTIVITY RHYTHMS AND MRI-DERIVED MEASURES OF BRAIN HEALTH IN OLDER ADULTS | PDF",1790645677]