[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-413600-105":59,"doc-detail-413600-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","chronic-pain-and-hypertension-and-mediation-role-of-inflammation-and-depression","Chronic pain and hypertension and mediation role of inflammation and depression","","Background: The association between chronic pain and incident hypertension is unclear. This study examined how pain characteristics—type, location, and spread—relate to incident hypertension, and whether these links are mediated by inflammation, depression, or medication. Using 206,963 UK Biobank participants, multivariable Cox proportional regression assessed baseline touchscreen pain measures against hypertension outcomes. Over 13.5 years, dose-related chronic pain sites and multiple pain sites increased hypertension risk; depression and CRP-mediated effects accounted for 11.7% of the association.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/chronic-pain-and-hypertension-and-mediation-role-of-inflammation-and-depression/413600/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/chronic-pain-and-hypertension-and-mediation-role-of-inflammation-and-depression/413600.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about chronic pain and hypertension?","Question",{"text":112,"@type":113},"It evaluates whether chronic pain and specific pain characteristics are associated with incident hypertension, and whether inflammation, depression, or medication mediate this relationship.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was incident hypertension measured in the study?",{"text":117,"@type":113},"Incident hypertension was ascertained from linkage to health records, using baseline pain information collected via a touchscreen questionnaire.",{"name":119,"@type":110,"acceptedAnswer":120},"What did mediation analysis show about depression and inflammation?",{"text":121,"@type":113},"Depression and inflammation (measured by C-reactive protein) mediated 11.7% of the association between chronic pain and hypertension, with depression accounting for 11.3% and inflammation for 0.4%.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},413600,1790811638,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Europe PMC unders uthManuscripts Europe M eC und Author Manuscripts  \n| Europe PMC Funders Group\u003Cbr>Author Manuscript\u003Cbr>Hypertension. Author manuscript; available in PMC 2026 January 01. |\n| --- |\n| Published in final edited form as:\u003Cbr>Hypertension. 2026 January 01; 83(1): 146–156. doi:10.1161/HYPERTENSIONAHA.125.25544 .\u003Cbr>Chronic pain and hypertension and mediation role of inflammation and depression\u003Cbr>Pei Qin 1 , Frederick K. Ho 1 , Carlos A. Celis-Morales3,4 , Jill P. Pell 1,*\u003Cbr>1School of Health and Wellbeing, University of Glasgow, Glasgow UK.\u003Cbr>3School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow UK.\u003Cbr>4 Human Performance Lab, Education, Physical Activity and Health Research Unit, University Católica del Maule, Talca, Chile.\u003Cbr>5Centro de Investigación en Medicina de Altura (CEIMA), Universidad Arturo Prat, Iquique, Chile.\u003Cbr>Abstract\u003Cbr>Background: The association between chronic pain and incident hypertension is unclear. This study aimed to investigate the associations between different pain characteristics (pain type, location and spread) and incident hypertension, and whether they were mediated by inflammation, depression or medication.\u003Cbr>Methods: In a cohort study of 206,963 UK Biobank participants, multivariable Cox-proportional regression was used to investigate the associations between pain at baseline, measured via a touchscreen questionnaire, and incident hypertension ascertained from linkage to health records.\u003Cbr>Mediation analysis was conducted to estimate the percentage of the association mediated by inflammation, depression and medications.\u003Cbr>Results: Over a median follow-up of 13.5 years, 19,911 (9 .62%) participants developed hypertension. Compared with no pain, those with short-term pain (hazard ratio [HR] 1.10, 95% confidence interval [CI], 1.03–1.17), chronic localized pain (HR 1.20, 95% CI 1.14–1.26) and chronic widespread pain (HR 1.75, 95% CI 1.52–2.00) had increased risk of hypertension. A dose-relationship also existed between the number of chronic pain sites and hypertension. Chronic headache, neck, back, abdominal, hip and widespread pain were all associated with increased risk of hypertension, as was chronic musculoskeletal pain. Together, depression (11.3%) and inflammation (0.4%), as measured by C-reactive protein, mediated 11.7% of the association between chronic pain and hypertension.\u003Cbr>This work is licensed under a BY 4.0 International license.\u003Cbr>*Corresponding Author: Professor Jill Pell CBE, School of Health and Wellbeing, Clarice Pears Building, 90 Byres Road, University of Glasgow, G12 8TB, United Kingdom, [Jill.Pell@glasgow.ac.uk](Jill.Pell@glasgow.ac.uk).\u003Cbr>Author contribution statement\u003Cbr>Pei Qin performed the data analysis, and original draft writing; Frederick K. Ho and Carlos A. Celis-Morales contributed to data curation, interpreting the findings, review and editing of the manuscript; Jill P. Pell contributed to data curation, supervision, validation, review and editing of the manuscript.\u003Cbr>Conflict of interest\u003Cbr>None declared.\u003Cbr>Ethical approval\u003Cbr>UK Biobank received ethical approval from the North-West Multi-centre Research Ethics Committee (reference: 11/NW/03820) . |\n\nEurope PMC unders uthManuscripts Europe M eC und Author Manuscripts  \nQin et al. Page 2  \nConclusions: People with chronic pain are at higher risk of developing hypertension, and this is partly explained by inflammation and depression. These findings reinforce the need for pain management, and the monitoring and early detection of hypertension.  \nAbstract  \nKeywords  \nchronic pain; chronic musculoskeletal pain; pain locations; hypertension; cohort  \nAbbreviations  \nBMI body mass index  \nCVD cardiovascular diseases  \nDBP diastolic blood pressure  \nHDL high-density lipoprotein  \nHbA1c glycated haemoglobin  \nLDL low-density lipoprotein  \nHypertension. Author manuscript; available in PMC 2026 January 01.  \nEurope PMC unders uthManuscripts Europe M eC und Author Manuscripts ","cbCairZ2v4o0c0OJ","https://ap.wps.com/l/cbCairZ2v4o0c0OJ","pdf",954006,22,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What question does the study address about chronic pain and hypertension?\",\"answer\":\"It evaluates whether chronic pain and specific pain characteristics are associated with incident hypertension, and whether inflammation, depression, or medication mediate this relationship.\"},{\"question\":\"How was incident hypertension measured in the study?\",\"answer\":\"Incident hypertension was ascertained from linkage to health records, using baseline pain information collected via a touchscreen questionnaire.\"},{\"question\":\"What did mediation analysis show about depression and inflammation?\",\"answer\":\"Depression and inflammation (measured by C-reactive protein) mediated 11.7% of the association between chronic pain and hypertension, with depression accounting for 11.3% and inflammation for 0.4%.\"}]","Chronic pain and hypertension and mediation role of inflammation and depression | PDF",1790595234,55]