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Prior work had focused on isolated cancer types, but this synthesis evaluates gastric cancer, oesophageal cancer, and oesophagogastric junction cancer using studies searched in PubMed, Embase, and Web of Science up to August 10, 2023. Results indicate elevated risks overall, with higher risk when CAG is diagnosed histologically than serologically.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/chronic-atrophic-gastritis-and-risk-of-incident-upper-gastrointestinal-cancers-a-systematic-review-and-meta-analysis/332043/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/chronic-atrophic-gastritis-and-risk-of-incident-upper-gastrointestinal-cancers-a-systematic-review-and-meta-analysis/332043.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the systematic review?","Question",{"text":112,"@type":113},"To assess the relationship between chronic atrophic gastritis (CAG) and the risk of incident upper gastrointestinal cancers, including gastric, oesophageal, and oesophagogastric junction cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases and timeframe were used for the literature search?",{"text":117,"@type":113},"PubMed, Embase, and Web of Science were searched from database inception until August 10, 2023.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the meta-analysis find about cancer risk for patients with CAG?",{"text":121,"@type":113},"CAG was associated with a statistically significant increased risk of incident gastric cancer, oesophageal cancer, oesophageal squamous cell carcinoma, and oesophagogastric junction cancer.",{"name":123,"@type":110,"acceptedAnswer":124},"Does the method used to diagnose CAG affect the cancer risk estimates?",{"text":125,"@type":113},"Yes. For the same cancer type, histological diagnosis of CAG was linked to a higher risk than serological diagnosis.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332043,1790094234,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Li et al. Journal of Translational Medicine (2024) 22:429  \n[https://doi.org/10.1186/s12967-023-04736-w](https://doi.org/10.1186/s12967-023-04736-w)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nChronic atrophic gastritis and risk of incident upper gastrointestinal cancers: a systematic review and meta-analysis  \nJunqiu Li 1† , Jielu Pan1†, Dinghong Xiao1, Nan Shen1, Ruiqing Wang1, Hongyv Miao1, Peimin Pu 1, Haiyan Zhang1, Xiao Yv1* and Lianjun Xing1*  \nAbstract  \nBackground Previous literature has explored the relationship between chronic atrophic gastritis (CAG) and isolated cancers within the upper gastrointestinal cancers; However, an integrative synthesis across the totality of upper gastrointestinal cancers was conspicuously absent. The research objective was to assess the relationship between CAG and the risk of incident upper gastrointestinal cancers, specifically including gastric cancer, oesophageal cancer, and oesophagogastric junction cancer.  \nMethods Rigorous systematic searches were conducted across three major databases, namely PubMed, Embase and Web of Science, encompassing the timeline from database inception until August 10, 2023. We extracted the necessary odds ratio (OR) and their corresponding 95% confidence interval (CI) for subsequent meta-analysis. Statistical analyses were conducted using Stata 17.0 software.  \nResults This meta-analysis included a total of 23 articles encompassing 5858 patients diagnosed with upper gastrointestinal cancers. CAG resulted in a statistically significant 4 . 12-fold elevated risk of incident gastric cancer (OR = 4 . 12, 95% CI 3.20–5. 30) . Likewise, CAG was linked to a 2. 08-fold increased risk of incident oesophageal cancer (OR = 2 . 08, 95%CI 1.60–2. 72) . Intriguingly, a specific correlation was found between CAG and the risk of incident oesophageal squamous cell carcinoma (OR = 2 . 29, 95%CI 1.77–2. 95), while no significant association was detected for oesophageal adenocarcinoma (OR = 0 . 62, 95%CI 0.17–2. 26) . Moreover, CAG was correlated with a 2. 77-fold heightened risk of oesophagogastric junction cancer (OR = 2 . 77, 95%CI 2.21–3.46) . Notably, for the same type of upper gastrointestinal cancer, it was observed that diagnosing CAG through histological methods was linked to a 33–77% higher risk of developing cancer compared to diagnosing CAG through serological methods.  \nConclusion This meta-analysis indicated a two-to fourfold increased risk of gastric cancer, oesophageal cancer, and oesophagogastric junction cancer in patients with CAG. Importantly, for the same upper gastrointestinal cancer, the risk of incident cancer was higher when CAG was diagnosed histologically compared to serological diagnosis. Further rigorous study designs are required to explore the impact of CAG diagnosed through both diagnostic methodson the risk of upper gastrointestinal cancers.  \n†Junqiu Li and Jielu Pan have contributed equally to this work.  \n*Correspondence: Xiao Yv [richie_xiao@163.com](richie_xiao@163.com)[ ](richie_xiao@163.com)Lianjun Xing [xingdoctor@126.com](xingdoctor@126.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this lic","cbCaigVvFWjSf4ZQ","https://ap.wps.com/l/cbCaigVvFWjSf4ZQ","pdf",1987235,"English","# Abstract\n# Introduction\n## Global cancer burden\n## Upper gastrointestinal cancer types and risk factors\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What was the main objective of the systematic review?\",\"answer\":\"To assess the relationship between chronic atrophic gastritis (CAG) and the risk of incident upper gastrointestinal cancers, including gastric, oesophageal, and oesophagogastric junction cancers.\"},{\"question\":\"Which databases and timeframe were used for the literature search?\",\"answer\":\"PubMed, Embase, and Web of Science were searched from database inception until August 10, 2023.\"},{\"question\":\"What did the meta-analysis find about cancer risk for patients with CAG?\",\"answer\":\"CAG was associated with a statistically significant increased risk of incident gastric cancer, oesophageal cancer, oesophageal squamous cell carcinoma, and oesophagogastric junction cancer.\"},{\"question\":\"Does the method used to diagnose CAG affect the cancer risk estimates?\",\"answer\":\"Yes. For the same cancer type, histological diagnosis of CAG was linked to a higher risk than serological diagnosis.\"}]","Chronic atrophic gastritis and risk of incident upper gastrointestinal cancers - a systematic review and meta-analysis | PDF",1789996441,48]