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Chronic atrophic gastritis increases cancer evolvement risk and contributes to GCP formation. Endoscopic resection offers an effective, minimally invasive treatment for GCPs.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/chronic-active-and-atrophic-gastritis-as-significant-contributing-factor-to-the-development-of-gastric-cystica-profunda/337776/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/chronic-active-and-atrophic-gastritis-as-significant-contributing-factor-to-the-development-of-gastric-cystica-profunda/337776.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is gastric cystica profunda (GCP) and why is it clinically significant?","Question",{"text":63,"@type":64},"GCP is an uncommon gastric lesion with a precancerous potential, making it important despite often subtle clinical symptoms and endoscopic findings.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do chronic active and atrophic gastritis contribute to GCP development?",{"text":68,"@type":64},"The article states that, in addition to prior mucosal injury from procedures, chronic active and atrophic gastritis can lead to the development of GCPs.",{"name":70,"@type":61,"acceptedAnswer":71},"How can atrophy stage in gastritis be determined in the context of GCP?",{"text":72,"@type":64},"By carefully examining the stomach and taking biopsy samples from susceptible regions, the stage of atrophy can be determined.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337776,1790376308,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":124},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 May 7; 30(17): 2308-2310  \nDOI: 10.3748/wjg.v30.i17.2308 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nEDITORIAL  \nChronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda  \nVeronika Papp, Pál Miheller  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade A  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Gao F, China  \nReceived: February 18, 2024  \nRevised: March 20, 2024  \nAccepted: April 15, 2024  \nPublished online: May 7, 2024  \nVeronika Papp, Pál Miheller, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest 1082, Hungary  \nCorresponding author: Veronika Papp, MD, PhD, Adjunct Professor, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 78 Üllői Street, Budapest 1082, [Hungary.](Hungary. papp.veronika@semmelweis.hu)[ papp.veronika@semmelweis.hu](Hungary. papp.veronika@semmelweis.hu)  \nAbstract  \nGastric cystica profunda (GCP) is an uncommon but underestimated gastric lesion. Its precancerous potential determines its significance. In addition to previous mucosa injury due to operations, biopsy or polypectomy, chronic active and atrophic gastritis may also lead to the development of GCPs. By carefully examining the stomach and taking biopsy samples from the susceptible regions, the stage of atrophy can be determined. Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation. GCPs frequently occur close to early gastric cancers (EGCs) or EGC can arise from the cystic glands. Endoscopic resection is an effective and minimally invasive treatment in GCP.  \nKey Words: Gastric cystica profunda; Chronic active gastritis; Atrophic gastritis; Operative Link for Gastritis Assessment staging; Early gastric cancer; Endoscopic resection  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Gastric cystica profunda (GCP) is a premalignant lesion developing on basis of ischemia. Chronic active or atrophic gastritis are considered to be a significant etiological factors in the development of GCPs and carry a risk for cancer formation. GCPs, with or without early gastric cancer, can be removed effectively by endoscopic resection.  \nCitation: Papp V, Miheller P. Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda. World J Gastroenterol 2024; 30(17): 2308-2310  \nURL: [https://www.wjgnet.com/1007-9327/full/v30/i17/2308.htm](https://www.wjgnet.com/1007-9327/full/v30/i17/2308.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v30.i17.2308](https://dx.doi.org/10.3748/wjg.v30.i17.2308)  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 2308 May 7, 2024  Volume 30  Issue 17   \nPapp V et al. Chronic gastritis and GCP development  \nINTRODUCTION  \nIn this editorial we comment on the article by Geng et al [1] published in the recent issue of the World Journal of Gastroenterology.  \nGastric cystica profunda (GCP) is a rare gastric lesion characterized by poor clinical symptoms and mostly unremarkable endoscopic features. Therefore, the incidence of a polypoid cystic ectasia of the gastric glands is underestimated [2] . It’s pathomechanism remains obscure. A prior stomach operations, biopsy, or polypectomy can cause the development of GCP. In contrast, mucosa damage or ischaemia are factors that commonly manifest in chronic active andatrophic gastritis. Carcinoma cascade is well known since the last decade, intestinal metaplasia occurs following t","cbCais74tn5WVe1V","https://ap.wps.com/l/cbCais74tn5WVe1V","pdf",346785,"English","# Abstract\n# Introduction\n## Pathogenesis and clinical significance\n## Diagnostic considerations and follow-up\n## Role of endoscopic procedures","[{\"question\":\"What is gastric cystica profunda (GCP) and why is it clinically significant?\",\"answer\":\"GCP is an uncommon gastric lesion with a precancerous potential, making it important despite often subtle clinical symptoms and endoscopic findings.\"},{\"question\":\"How do chronic active and atrophic gastritis contribute to GCP development?\",\"answer\":\"The article states that, in addition to prior mucosal injury from procedures, chronic active and atrophic gastritis can lead to the development of GCPs.\"},{\"question\":\"How can atrophy stage in gastritis be determined in the context of GCP?\",\"answer\":\"By carefully examining the stomach and taking biopsy samples from susceptible regions, the stage of atrophy can be determined.\"}]","Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda | PDF",1790020577]