[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-458717-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-458717-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","choroidal-neovascularization-as-a-trigger-for-central-serous-chorioretinopathy-research-open-access","Choroidal neovascularization as a trigger for central serous chorioretinopathy - Research Open Access","","Investigates whether choroidal neovascularization (CNV) can occasionally precipitate central serous chorioretinopathy (CSCR) in pachychoroid patients, focusing on cases where fluorescein angiography (FA)-confirmed leakage originates directly within the CNV lesion. A retrospective case series from two tertiary centers evaluated first-episode CSCR without prior CSCR history, requiring at least one FA-confirmed leakage point within the neovascular complex and using FA, SD-OCT, and OCTA to assess topographic colocalization. Four of 202 met criteria, showing precise colocalization and subfoveal mature CNV, with fluid fluctuations sometimes independent of anti-VEGF.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/choroidal-neovascularization-as-a-trigger-for-central-serous-chorioretinopathy-research-open-access/458717/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/choroidal-neovascularization-as-a-trigger-for-central-serous-chorioretinopathy-research-open-access/458717.png","ImageObject",300,407,{"name":42,"@type":43},"Franzy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about CNV and CSCR?","Question",{"text":63,"@type":64},"It examines whether choroidal neovascularization (CNV) may sometimes directly trigger acute central serous chorioretinopathy (CSCR) in patients with pachychoroid features, specifically when FA-confirmed leakage arises within the CNV lesion.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients selected for inclusion?",{"text":68,"@type":64},"Patients had a first episode of CSCR with coexisting CNV and no prior history or signs of CSCR. Inclusion required at least one fluorescein angiography (FA)-confirmed leakage point located within the neovascular complex.",{"name":70,"@type":61,"acceptedAnswer":71},"What imaging was used to evaluate the relationship between leakage and CNV?",{"text":72,"@type":64},"The study used multimodal imaging: fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA) to detect CNV and determine whether leakage points precisely colocalized with the CNV lesion.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},458717,1791477933,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Vienne-Jumeau etal. International Journal of Retina and Vitreous (2026) 12:4  \n[https://doi.org/10.1186/s40942-025-00761-7](https://doi.org/10.1186/s40942-025-00761-7)  \nInternational Journal of Retina and Vitreous  \nRESEARCH Open Access  \nChoroidal neovascularization as a trigger for central serous chorioretinopathy  \nAliénor Vienne-Jumeau 1,2*, Elodie Bousquet3, Jacques Bijon4, Sarah Mrejen 1,5 and Francine Behar-Cohen2,6,7  \nAbstract  \nBackground To investigate whether choroidal neovascularization (CNV) may occasionally precipitate central serous chorioretinopathy (CSCR) in patients with pachychoroid features, by analyzing cases where fluorescein angiography (FA)-confirmed leakage originated directly within the CNV lesion.  \nMethods In this retrospective case series conducted at two tertiary referral centers, we reviewed patients with no prior history or signs of CSCR who presented with a first episode of CSCR and coexisting CNV between December 2024 and April 2025. Inclusion required at least one FA-confirmed leakage point located within the neovascular complex. Multimodal imaging—including FA, spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA)—was performed to detect CNV and evaluate its topographical relationship with leakage.  \nResults Among 202 patients screened, four met inclusion criteria (two males, two females; age range 54–58 years) . All presented with a unilateral first episode of CSCR. In each case, FA and OCTA demonstrated precise colocalization of the leakage point within the CNV lesion. CNV was predominantly subfoveal and exhibited a mature morphology. Three patients were diagnosed simultaneously with CSCR and a neovascular membrane, while one developed CSCR during follow-up of a previously identified pachychoroid neovasculopathy. Subretinal fluid fluctuations were observed in all cases and often appeared independent of anti-VEGF treatment, suggesting a mechanism not exclusively driven by VEGF-mediated CNV activity.  \nConclusions This case series suggests that, within the pachychoroid spectrum, CNV may not only complicate chronic or complex CSCR but may also act as a direct trigger of acute episodes. These findings underscore the importance of multimodal imaging, particularly FA and OCTA, for comprehensive assessment of CSCR. Given the small sample size and retrospective design, these observations should be interpreted as hypothesis-generating and warrant confirmation in larger prospective studies.  \nKeywords Choroidal neovascularization, Pachychoroid neovascularization, Central serous chorioretinopathy, Leakage point, Optical coherence tomography  \n*Correspondence: Aliénor Vienne-Jumeau[avienne@15-20.fr](avienne@15-20.fr)  \n1Centre Hospitalier National d’Ophtal mologie des Quinze-Vingts, Paris, France  \n2Ophtal mopôle, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France  \n3Department of Ophthalmology, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France  \n4Department of Ophthalmology, Rothschild Foundation Hospital, 29 Rue Manin, Paris 75019, France  \n5Ophthalmology Center for Imaging and Laser, Paris, France  \n6Centre de Recherche des Cordeliers, Université Paris Cité, INSERM U1138, Université Sorbonne Paris Cité, Paris 75006, France  \n7Department Ophthalmology Hôpital Foch, Suresnes, France  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creat","cbCaiqhjKftcNj6Q","https://ap.wps.com/l/cbCaiqhjKftcNj6Q","pdf",2544602,11,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions\n# Introduction","[{\"question\":\"What question does the study address about CNV and CSCR?\",\"answer\":\"It examines whether choroidal neovascularization (CNV) may sometimes directly trigger acute central serous chorioretinopathy (CSCR) in patients with pachychoroid features, specifically when FA-confirmed leakage arises within the CNV lesion.\"},{\"question\":\"How were patients selected for inclusion?\",\"answer\":\"Patients had a first episode of CSCR with coexisting CNV and no prior history or signs of CSCR. Inclusion required at least one fluorescein angiography (FA)-confirmed leakage point located within the neovascular complex.\"},{\"question\":\"What imaging was used to evaluate the relationship between leakage and CNV?\",\"answer\":\"The study used multimodal imaging: fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA) to detect CNV and determine whether leakage points precisely colocalized with the CNV lesion.\"}]","Choroidal neovascularization as a trigger for central serous chorioretinopathy - Research Open Access | PDF",1790754181,28]