[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-400656-105":59,"doc-detail-400656-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","choosing-daily-vs-on-demand-prep","Choosing Daily vs. On-Demand PrEP","","Learning Community session notes from July 19 outline how to compare daily and on-demand PrEP approaches, including group agreements and clinic introductions. Content focuses on defining on-demand (event-based/2:1:1 and related terms), eligibility concepts, and the evidence base. It summarizes key trial findings such as Ipergay results and open-label extension effectiveness, and outlines patient evaluation screening for on-demand dosing adherence and follow-up.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/choosing-daily-vs-on-demand-prep/400656/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/choosing-daily-vs-on-demand-prep/400656.png","ImageObject",300,407,{"name":92,"@type":93},"pop out","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-27",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does “on-demand” PrEP mean in these notes?","Question",{"text":112,"@type":113},"“On-Demand” refers to event-based strategies (including “2:1:1” and related terminology) where dosing is not daily. It involves taking Truvada (TDF/FTC) around sexual activity or higher-risk periods.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which medication is recommended for on-demand PrEP in the notes?",{"text":117,"@type":113},"Truvada (TDF/FTC) is described as the only pre-exposure prophylaxis medication recommended for on-demand use at this time.",{"name":119,"@type":110,"acceptedAnswer":120},"What patient criteria are used for on-demand dosing screening?",{"text":121,"@type":113},"The notes highlight men who have sex with men with sex less than twice a week, ability to adhere to quarterly visits and STI screening without a quarterly prescription trigger, and expressed understanding of the dosing schedule.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},400656,1791754307,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090760408,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Choosing Daily vs . On-Demand PrEP  \nLearning Community, July 19th  \nWelcome! Please introduce yourself in the chat J  \nWelcome!  \n• Please introduce yourself in the chat!  \n• We’re happy to have attendees here from the following clinics:  \n– Bell Flower Clinic, Indianapolis, Indiana  \n– Litoral Clinic, Migrant Health Center, Mayagüez, Puerto Rico  \n– Mary Eliza Mahoney Health Center, Newark, New Jersey  \n– Morrisania Clinic, Health & Hospitals, Bronx, New York  \n– NYC Department of Health, NYC, New York  \n– Take Care Down There Clinic, Columbus Public Health, Columbus, Ohio  \nGroup Agreements  \n• Keep cameras on, especially when talking  \n• All participants contribute to the discussion  \n• We’re here to learn together  \n• Confidentiality: any patient information shared remains private  \nClinics Share  \nv What is your experience with on-demand PrEP?  \nv What concerns, if any, do you have about providing on-demand PrEP?  \no Especially if you are not currently providing on-demand PrEP  \nv How has the patient response been to on-demand vs. daily PrEP?  \nChoosing Daily vs. On Demand PrEP  \nCaroline Carnevale, DNP, MPH, AAHIVS  \nPrEP On-Demand  \n• Agenda  \n– Defining “On-Demand”  \n– Background  \n– How to Screen Patients for On-Demand  \n– Dosing schedule variations  \n– Patient scenarios  \nPrEP On-Demand  \n• Definition  \n– “On-Demand” or “Event-Based” or “2:1:1” or “Intermittent” or “Pericoital” or “Vacation” PrEP  \n• Any dosing schedule variation that is not “Daily Dosing”  \n–Taking PrEP, specifically Truvada (TDF/FTC), around the time of asexual encounter(s) or “riskier” periods  \n• Truvada (TDF/FTC) is the only pre-exposure prophylaxis medication recommended for On-Demand at this time  \nPrEP On-Demand: Background  \n• Background  \n– Ipergay  \n• Results originally presented in 2014  \n• Demonstrated that use of on-demand PrEP reduced HIV transmissions by 86% compared with the placebo  \n• 414 MSM and Bisexual men enrolled in study  \n• Average of one sexual encounter per week & average 16 pills per month  \n• Open Label Extension – 97% effective in preventing HIV transmission  \nMolina JM, Capitant C, Spire B, et al. On demand PrEP with oral TDF-FTC in MSM: results of the ANRS Ipergay trial. CROI 2015. February 23-26, 2015. Seattle, Washington. Abstract 23.  \nMolina JM, et all. Efficacy of on demand PrEP with TDF-FTC in the ANRS IPERGAY open-label extension study. IAS-AIDS 2016. Durban, South African. Abstract 2564.  \nPrEP On-Demand: Background  \n• Background  \n–Does 2:1:1 work with infrequent sex?  \n• Ad-hoc analysis of Ipergay data  \n• Participants who took less than 15 pills per month included in analysis  \n• 6 infections in the placebo arm and 0 infections in the TDF/FTC arm  \n• On demand is highly effective even for MSM who have infrequent sex  \nAntoni, G. , Tremblay, C. , Delaugerre , C. , Charreau , I. , Cua , E. , Castro, D. R. , ... & Wainberg , M. (2020) . On-demand pre-exposure prophylaxis with tenofovir disoproxilfumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial. The Lancet HIV, 7(2), e113-e120 .  \nPrEP-On-Demand: Patient Evaluation  \n• Screening for On-Demand Dosing  \n–Men who have sex with Men (MSM)  \n–Has sex less than twice a week  \n–Patient able to adhere to quarterly visits/STI screening in the absence of a quarterly prescription trigger  \n–Expressed understanding of dosing schedule","cbCaik66w6hVWAwD","https://ap.wps.com/l/cbCaik66w6hVWAwD","pdf",1398789,26,"English","# Choosing Daily vs. On-Demand PrEP\n## Group Agreements\n## Clinics Share\n## PrEP On-Demand\n## PrEP On-Demand: Background\n## PrEP-On-Demand: Patient Evaluation","[{\"question\":\"What does “on-demand” PrEP mean in these notes?\",\"answer\":\"“On-Demand” refers to event-based strategies (including “2:1:1” and related terminology) where dosing is not daily. It involves taking Truvada (TDF/FTC) around sexual activity or higher-risk periods.\"},{\"question\":\"Which medication is recommended for on-demand PrEP in the notes?\",\"answer\":\"Truvada (TDF/FTC) is described as the only pre-exposure prophylaxis medication recommended for on-demand use at this time.\"},{\"question\":\"What patient criteria are used for on-demand dosing screening?\",\"answer\":\"The notes highlight men who have sex with men with sex less than twice a week, ability to adhere to quarterly visits and STI screening without a quarterly prescription trigger, and expressed understanding of the dosing schedule.\"}]","Choosing Daily vs. On-Demand PrEP | PDF",1790513011,66]