[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406106-105":59,"doc-detail-406106-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cholesterol-reprograms-glucose-and-lipid-metabolism-to-promote-proliferation-in-colon-cancer-cells","Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells","","Hypercholesterolemia is frequently linked to obesity, which increases risk for multiple cancers, yet the mechanisms by which elevated circulatory or dietary cholesterol contributes to cancer remain unclear. This study shows that high-cholesterol/high-fat diets raise chemical carcinogen-induced colon polyp incidence and tumor progression in mice. At the cellular level, LDLc and HDLc enhance colon cancer proliferation by reshaping glucose and lipid metabolism toward glycolysis, increasing lactate and ATP via glycolysis while reducing OXPHOS.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cholesterol-reprograms-glucose-and-lipid-metabolism-to-promote-proliferation-in-colon-cancer-cells/406106/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cholesterol-reprograms-glucose-and-lipid-metabolism-to-promote-proliferation-in-colon-cancer-cells/406106.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does hypercholesterolemia relate to cancer risk in this study?","Question",{"text":112,"@type":113},"The study addresses the unclear mechanisms linking elevated blood or dietary cholesterol to cancer, building on observations that abnormal cholesterol levels occur in colon cancer patients and may promote tumorigenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What effects do high-cholesterol or high-fat diets have in the mouse model?",{"text":117,"@type":113},"The study demonstrates increased incidence of chemical carcinogen-induced colon polyps and accelerated tumor progression in mice under high-cholesterol/high-fat dietary conditions.",{"name":119,"@type":110,"acceptedAnswer":120},"How do LDLc and HDLc promote colon cancer cell proliferation mechanistically?",{"text":121,"@type":113},"LDLc/HDLc supplementation increases cellular glucose uptake and utilization, drives higher lactate production, upregulates aerobic glycolysis to raise ATP through glycolysis, and decreases ATP generation by OXPHOS, supporting a glycolytic phenotype for rapid proliferation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406106,1790815730,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Mayengbam etal. Cancer & Metabolism (2023) 11:15 [https://doi.org/10.1186/s40170-023-00315-1](https://doi.org/10.1186/s40170-023-00315-1)  \nCancer & Metabolism  \n RESEARCH Open Access  \nCholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells  \nShyamananda Singh Mayengbam 1, Abhijeet Singh1, Himanshi Yaduvanshi1, Firoz Khan Bhati 1, Bhavana Deshmukh1, Dipti Athavale1, Pranay L. Ramteke 1 and Manoj Kumar Bhat1*  \nAbstract  \nHypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the role of increased circulatory cholesterol or dietary cholesterol intake towards cancer etiology and pathology. Recently, abnormality in the blood cholesterol level of colon cancer patients has been reported. In the present study, we demonstrate that alteration in cholesterol levels (through a high-cholesterol or high-fat diet) increases the incidence of chemical carcinogen-induced colon polyp occurrence and tumor progression in mice. At the cellular level, low-density lipoprotein cholesterol (LDLc) and high-density lipoprotein cholesterol (HDLc) promote colon cancer cell proliferation by tuning the cellular glucose and lipid metabolism. Mechanistically, supplementation of LDLc or HDLc promotes cellular glucose uptake, and utilization, thereby, causing an increase in lactate production by colon cancer cells. Moreover, LDLc or HDLc upregulates aerobic glycolysis, causing an increase in total ATP production through glycolysis, and a decrease in ATP generation by OXPHOS. Interestingly, the shift in the metabolic status towards a more glycolytic phenotype upon the availability of cholesterol supports rapid cell proliferation. Additionally, an alteration in the expression of the molecules involved in cholesterol uptake along with the increase in lipid and cholesterol accumulation was observed in cells supplemented with LDLc or HDLc. These results indicate that colon cancer cells directly utilize the cholesterol associated with LDLc or HDLc. Moreover, targeting glucose metabolism through LDH inhibitor (oxamate) drastically abrogates the cellular proliferation induced by LDLc or HDLc. Collectively, we illustrate the vital role of cholesterol in regulating the cellular glucose and lipid metabolism of cancer cells and its direct effect on the colon tumorigenesis.  \nKeywords LDLc, HDLc, Cholesterol, Glucose metabolism, Lipid metabolism, Colon cancer  \nThis work was carried out for the partial fulfilment of a PhD thesis (of S. S. M.) submitted to Savitribai Phule Pune University, Pune, India.  \n*Correspondence: Manoj Kumar Bhat [manojkbhat@nccs. res.in](manojkbhat@nccs. res.in)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2023, Article corrected in 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver)[. The Creative Commons Public Domain Dedication waiver](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedicatio","cbCaihQYnEjyKcE4","https://ap.wps.com/l/cbCaihQYnEjyKcE4","pdf",5554314,22,"English","# Abstract\n## Background\n## Study outcomes","[{\"question\":\"How does hypercholesterolemia relate to cancer risk in this study?\",\"answer\":\"The study addresses the unclear mechanisms linking elevated blood or dietary cholesterol to cancer, building on observations that abnormal cholesterol levels occur in colon cancer patients and may promote tumorigenesis.\"},{\"question\":\"What effects do high-cholesterol or high-fat diets have in the mouse model?\",\"answer\":\"The study demonstrates increased incidence of chemical carcinogen-induced colon polyps and accelerated tumor progression in mice under high-cholesterol/high-fat dietary conditions.\"},{\"question\":\"How do LDLc and HDLc promote colon cancer cell proliferation mechanistically?\",\"answer\":\"LDLc/HDLc supplementation increases cellular glucose uptake and utilization, drives higher lactate production, upregulates aerobic glycolysis to raise ATP through glycolysis, and decreases ATP generation by OXPHOS, supporting a glycolytic phenotype for rapid proliferation.\"}]","Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells | PDF",1790563588,55]