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A 35-year-old man developed pneumonia after contact with parrots, presenting with fever, cough, yellow sputum, and later psychiatric manifestations alongside pneumomediastinum and cervical emphysema. Initial broad-spectrum antibiotics failed, while targeted next-generation sequencing identified C. abortus. Doxycycline plus moxifloxacin led to resolution and near-complete recovery on follow-up imaging.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/chlamydia-abortus-induced-pneumonia-with-psychiatric-symptoms-and-pneumomediastinum-a-case-report/420363/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/chlamydia-abortus-induced-pneumonia-with-psychiatric-symptoms-and-pneumomediastinum-a-case-report/420363.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main clinical presentation in the reported case?","Question",{"text":112,"@type":113},"A 35-year-old man had pneumonia with psychiatric symptoms and pneumomediastinum, along with cervical subcutaneous emphysema. Imaging also showed bilateral pulmonary inflammation and emphysema patterns.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which diagnostic method confirmed Chlamydia abortus?",{"text":117,"@type":113},"Targeted next-generation sequencing (Targeted NGS) of bronchoalveolar lavage fluid identified Chlamydia abortus.",{"name":119,"@type":110,"acceptedAnswer":120},"Why did the initial treatment not work?",{"text":121,"@type":113},"Initial antibiotics, cefotaxime and piperacillin-tazobactam, did not improve the patient’s condition. Chest CT findings continued to show significant pulmonary inflammation and emphysema.",{"name":123,"@type":110,"acceptedAnswer":124},"How was the patient treated and what was the outcome?",{"text":125,"@type":113},"Treatment with doxycycline and moxifloxacin resolved fever, psychiatric symptoms, and pulmonary lesions. The patient continued oral doxycycline after discharge, and follow-up CT showed near-complete recovery.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},420363,1790706630,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":46},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Infection and Drug Resistance  \n Open Access Full Text Article  \nC ASE REPORT  \nChlamydia Abortus-Induced Pneumonia with Psychiatric Symptoms and Pneumomediastinum:  \nA Case Report  \nBing Ding *, Zengkai Xu*, Youtang Li, Zhiyi Ma   \nLongyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Zhiyi Ma, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyi North Road, Longyan, Fujian, 364000, People’s Republic of China, Email [fjlymzy@163.com](fjlymzy@163.com)  \n\n| Background: Chlamydia abortus is a zoonotic pathogen that commonly causes abortion, pelvic inflammatory disease, or septicemia during pregnancy in humans. It can occasionally lead to pneumonia.\u003Cbr>Case Presentation: We report a 35-year-old male with pneumonia complicated by psychiatric symptoms and pneumomediastinum. Initial treatment with cefotaxime and piperacillin-tazobactam failed. On admission, chest CT revealed bilateral pulmonary inflammation, pneumomediastinum, and cervical subcutaneous emphysema. Bronchoalveolar lavage fluid underwent Targeted Next-Generation Sequencing, identifying Chlamydia abortus. Treatment with doxycycline and moxifloxacin led to resolution of fever, psychiatric\u003Cbr>symptoms, and pulmonary lesions. The patient continued oral doxycycline post-discharge, and follow-up CT showed near-complete recovery.\u003Cbr>Conclusion: Chlamydia abortus infection can cause pneumonia with psychiatric symptoms, pneumomediastinum, and cervical emphysema—complications not previously reported. Targeted Next-Generation Sequencing (Targeted NGS) plays a crucial role in the early and precise detection of Chlamydia abortus, improving diagnostic accuracy and treatment timeliness. Doxycycline is effective in the treatment of Chlamydia abortus infection and contributed to the patient’s recovery.\u003Cbr>Keywords: Chlamydia abortus, pneumonia, psychiatric symptoms, pneumomediastinum, next-generation sequencing, case report |\n| --- |\n| Introduction\u003Cbr>Chlamydia is a type of obligate intracellular parasitic bacterium, a Gram-negative prokaryotic microorganism that undergoes a biphasic developmental cycle consisting of an extracellular and an intracellular phase.1,2 Chlamydia abortus belongs to the genus Chlamydia and is also a zoonotic pathogen. It commonly causes miscarriage, pelvic inflammatory disease, or septicemia during pregnancy in humans.3 In recent years, with the advancement and widespread application of next-generation sequencing (NGS) technology, Chlamydia abortus has also been increasingly recognized as a cause of human pneumonia. However, there have been no previously reported cases of Chlamydia abortus infection complicated by pneumomediastinum or psychiatric symptoms. We report a rare case of pneumonia caused by Chlamydia abortus complicated with psychiatric symptoms and pneumomediastinum. The objective of this report is to highlight the clinical features, diagnostic approach, and effective treatment strategies for C. abortus-induced pneumonia, thereby expanding the known clinical spectrum and providing guidance for future cases.\u003Cbr>Case Presentation\u003Cbr>A 35-year-old male salesperson with no history of smoking had contact with parrots about two weeks prior to symptom onset and began experiencing fever, cough, and sputum production 12 days before admission. Four days prior to presentation, he visited a local hospital with a body temperature of 40°C, accompanied by headache, profuse sweating, |\n\nReceived: 19 September 2025  \nAccepted: 22 December 2025  \nPublished: 30 December 2025  \nInfection and Drug Resistance 2025:18 6999–7006 6999  \n© 2025 Ding et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at [https://www.dovepress.com/terms.php](https://www.dovepress.com/terms.php)  \nand incorporate the Creative Commons Attribution – Non Commercial (unported, v","cbCaivXicXKw1POb","https://ap.wps.com/l/cbCaivXicXKw1POb","pdf",806780,"English","# Background\n# Case Presentation\n# Introduction\n# Case Presentation (Continued)\n# Conclusion","[{\"question\":\"What was the main clinical presentation in the reported case?\",\"answer\":\"A 35-year-old man had pneumonia with psychiatric symptoms and pneumomediastinum, along with cervical subcutaneous emphysema. Imaging also showed bilateral pulmonary inflammation and emphysema patterns.\"},{\"question\":\"Which diagnostic method confirmed Chlamydia abortus?\",\"answer\":\"Targeted next-generation sequencing (Targeted NGS) of bronchoalveolar lavage fluid identified Chlamydia abortus.\"},{\"question\":\"Why did the initial treatment not work?\",\"answer\":\"Initial antibiotics, cefotaxime and piperacillin-tazobactam, did not improve the patient’s condition. Chest CT findings continued to show significant pulmonary inflammation and emphysema.\"},{\"question\":\"How was the patient treated and what was the outcome?\",\"answer\":\"Treatment with doxycycline and moxifloxacin resolved fever, psychiatric symptoms, and pulmonary lesions. The patient continued oral doxycycline after discharge, and follow-up CT showed near-complete recovery.\"}]","Chlamydia Abortus-Induced Pneumonia with Psychiatric Symptoms and Pneumomediastinum - A Case Report | PDF",1790620675]