[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31796":3,"doc-seo-31796":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31796,8796095360427,"Lucas Martin","https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d",8,"Research & Report","Chitosan Nanoparticles with Controlled Size and Zeta Potential","Optimization of the chitosan nanoparticle (ChN) production process was carried out using a 2(5–2) fractional factorial design to quantify how viscosity average molecular weight (40–120 kDa), initial chitosan concentration (2–5 g/L), initial TPP concentration (0.8–1.2 g/L), chitosan/TPP ratio (4/1–10/1), and stirring speed (300–700 rpm) affect final average particle size and zeta potential. Ionotropic cross-linking with TPP produced ChNs characterized by Zetasizer Nano ZS, FTIR, XRD, and DSC. Size depended on concentration and molecular weight, while zeta potential was driven mainly by molecular weight, chitosan concentration, and stirring speed; FTIR confirmed TPP–chitosan charge interactions via new peaks at 1222 and 895 cm−1.","cbCaifNRGzGIdWEB","https://ap.wps.com/l/cbCaifNRGzGIdWEB","pdf",905606,1,11,"English","en","# Introduction\n## Abstract and objectives\n## Materials and ionotropic cross-linking concept\n## Key characterization parameters\n## Influencing factors and prior studies\n## Rationale for fractional factorial design","[{\"question\":\"How were chitosan nanoparticles produced in the study?\",\"answer\":\"Chitosan nanoparticles were prepared by ionotropic cross-linking between chitosan and tripolyphosphate (TPP), relying on electrostatic interactions under specific conditions.\"},{\"question\":\"Which factors were optimized to control nanoparticle size and zeta potential?\",\"answer\":\"The study varied viscosity average molecular weight, initial chitosan concentration, initial TPP concentration, the chitosan/TPP ratio, and stirring speed, then measured average particle size and zeta potential.\"},{\"question\":\"What analytical methods were used to characterize the produced nanoparticles?\",\"answer\":\"Zetasizer Nano ZS measured average particle size and surface charge, while FTIR, XRD, and DSC were used to confirm chemical interaction and assess structural/crystallinity effects of cross-linking.\"}]",1780174825,28,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"chitosan-nanoparticles-with-controlled-size-and-zeta-potential","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/chitosan-nanoparticles-with-controlled-size-and-zeta-potential/31796/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-30",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"How were chitosan nanoparticles produced in the study?","Question",{"text":73,"@type":74},"Chitosan nanoparticles were prepared by ionotropic cross-linking between chitosan and tripolyphosphate (TPP), relying on electrostatic interactions under specific conditions.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"Which factors were optimized to control nanoparticle size and zeta potential?",{"text":78,"@type":74},"The study varied viscosity average molecular weight, initial chitosan concentration, initial TPP concentration, the chitosan/TPP ratio, and stirring speed, then measured average particle size and zeta potential.",{"name":80,"@type":71,"acceptedAnswer":81},"What analytical methods were used to characterize the produced nanoparticles?",{"text":82,"@type":74},"Zetasizer Nano ZS measured average particle size and surface charge, while FTIR, XRD, and DSC were used to confirm chemical interaction and assess structural/crystallinity effects of cross-linking.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]