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High-risk SGC patients receiving surgery were retrospectively assigned to CRT or RT and analyzed with a multivariable Cox model after propensity score matching. Among 152 patients, CRT showed no overall survival or locoregional control advantage versus RT, but reduced cancer recurrence risk by 15% in T3/4, high-grade, and 5+ positive lymph node subgroups.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/chemoradiotherapy-versus-radiotherapy-in-high-risk-salivary-gland-cancer/336450/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/chemoradiotherapy-versus-radiotherapy-in-high-risk-salivary-gland-cancer/336450.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main objective of this study?","Question",{"text":113,"@type":114},"To investigate survival benefits of chemoradiotherapy versus radiotherapy in resected high-risk salivary gland cancer and whether benefits depend on the number of high-risk variables.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients assigned to treatment groups and analyzed?",{"text":118,"@type":114},"Patients who underwent surgery for high-risk SGC were retrospectively categorized into CRT or RT groups, and effects on locoregional control and overall survival were assessed using a multivariable Cox model after propensity score matching.",{"name":120,"@type":111,"acceptedAnswer":121},"Did CRT improve survival compared with RT overall?",{"text":122,"@type":114},"No. In the entire population, CRT did not show significant survival advantages for locoregional control or overall survival compared with RT.",{"name":124,"@type":111,"acceptedAnswer":125},"In which subgroups did adding chemotherapy to radiotherapy show benefit?",{"text":126,"@type":114},"Among patients with T3/4 stage, high-grade tumors, and 5 or more positive lymph nodes, chemotherapy added to RT was associated with a significantly reduced risk of cancer recurrence.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},336450,1790116930,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Shen and Shan World Journal of Surgical Oncology (2024) 22:181  \n[https://doi.org/10.1186/s12957-024-03456-9](https://doi.org/10.1186/s12957-024-03456-9)  \nWorld Journal of Surgical Oncology  \nRESEARCH Open Access  \nChemoradiotherapy versus radiotherapy in high risk salivary gland cancer  \nYicheng Shen 1 and Jiebo Shan 1*  \nAbstract  \nObjective The aim of this study was to investigate the potential survival benefits associated with chemoradiotherapy (CRT) as opposed to radiotherapy (RT) in patients with resected high-risk salivary gland cancer (SGC), with a specific focus on determining whether these benefits are influenced by the number of high-risk variables.  \nMethods Patients who underwent surgical treatment for high-risk SGC were retrospectively enrolled and categorized into either CRT or RT groups. The impact of adjuvant therapy on locoregional control (LRC) and overall survival (OS) was assessed using a multivariable Cox model.  \nResults A total of 152 patients were included following propensity score-matching. In comparison to RT, CRT did not demonstrate a significant survival advantage in terms of LRC (p = 0 .485, HR: 1. 14, 95%CI: 0 .36–4. 22) and OS (p = 0 . 367, HR: 0 . 99, 95%CI: 0 .17–3. 87) in entire population. But among patients with T3/4 stage, high-grade tumors, and 5 or more positive lymph nodes, the addition of chemotherapy to RT significantly (p = 0 . 042) correlated with a 15% reduction in the risk of cancer recurrence (95%CI: 4-54%) . Conversely, in other subgroups with varying combinations of high-risk variables, CRT did not provide additional survival benefits for LRC and OS compared to RT.  \nConclusion Adjuvant chemotherapy may be considered in conjunction with RT specifically in cases where there is a presence ofT3/4 stage, high-grade tumors, and 5 or more metastatic lymph nodes in high-risk SGC.  \nKeywords Salivary gland cancer, Chemoradiotherapy, Radiotherapy, Lymph node metastasis burden, Survival  \nIntroduction  \nSalivary gland cancer (SGC) is relatively rare, comprising only about 5% of all malignancies in the head and neck region [1], but it consists of 24 pathologic types based on the newest WHO classification [2]. Surgery accounts for the mainstay of treatment, according to the NCCN guideline, adjuvant radiotherapy (RT) is usually recommended if there are adverse pathologic features [3], extensive literature has confirmed RT contributes to improved  \n*Correspondence: Jiebo Shan [shanjiebo21@163.com](shanjiebo21@163.com)  \n1Department of Stomatology, Affiliated Hospital of Shaoxing University, Shaoxing 312000, China  \nlocoregional control (LRC), disease specific survival, and overall survival (OS) in cases presenting stage T3/4, lymph node (LN) metastasis, high pathologic grade, positive margin, perineural invasion (PNI), lymphovascular  \ninvasion (LVI), and extranodal extension (ENE) [4–8].  \nCurrent evidence regarding adjuvant chemoradiotherapy (CRT) for high-risk SGCs is notably scarce, being classified only as category 2B evidence in NCCN guideline [3]. Clinicians resorting to adjuvant CRT for SGCs often draw upon insights derived from two randomized clinical trials and subsequent pooled analyses that have demonstrated improved outcomes with postoperative CRT compared to RT alone in cases of head and necksquamous cell carcinoma [9–11]. Although it’s crucial to recognize that these pivotal trials have specifically  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included ","cbCaihNtLtFkQSaO","https://ap.wps.com/l/cbCaihNtLtFkQSaO","pdf",1796827,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Patients and methods","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To investigate survival benefits of chemoradiotherapy versus radiotherapy in resected high-risk salivary gland cancer and whether benefits depend on the number of high-risk variables.\"},{\"question\":\"How were patients assigned to treatment groups and analyzed?\",\"answer\":\"Patients who underwent surgery for high-risk SGC were retrospectively categorized into CRT or RT groups, and effects on locoregional control and overall survival were assessed using a multivariable Cox model after propensity score matching.\"},{\"question\":\"Did CRT improve survival compared with RT overall?\",\"answer\":\"No. In the entire population, CRT did not show significant survival advantages for locoregional control or overall survival compared with RT.\"},{\"question\":\"In which subgroups did adding chemotherapy to radiotherapy show benefit?\",\"answer\":\"Among patients with T3/4 stage, high-grade tumors, and 5 or more positive lymph nodes, chemotherapy added to RT was associated with a significantly reduced risk of cancer recurrence.\"}]","Chemoradiotherapy versus radiotherapy in high risk salivary gland cancer | PDF",1790015094,25]