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It also inhibited Escherichia coli and Pseudomonas aeruginosa. GC-MS and LC-MS identified multiple components, and molecular docking assessed interactions with AKT-1, COX-2, and HER-2, suggesting promising bioactivity requiring further evaluation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/chemical-profiling-and-biological-activity-of-psydrax-dicoccos-gaertn/384161/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/chemical-profiling-and-biological-activity-of-psydrax-dicoccos-gaertn/384161.png","ImageObject",300,407,{"name":42,"@type":43},"McGucket","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",20,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What plant material and extract were evaluated in the study?","Question",{"text":63,"@type":64},"The study evaluated Psydrax dicoccos Gaertn evergreen tree leaves, using a methanol extract for biological testing.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the extract perform against breast cancer cells?",{"text":68,"@type":64},"The methanol extract exhibited cytotoxic effects against MCF7 breast cancer cells with an IC50 value reported as 34 μg/mL.",{"name":70,"@type":61,"acceptedAnswer":71},"Which biochemical assays and computational methods were used to assess activity?",{"text":72,"@type":64},"Antioxidant activity was measured using DPPH and ABTS assays, anti-inflammatory potential was assessed across concentrations, and GC-MS/LC-MS were used for component identification. Molecular docking evaluated interactions with AKT-1, COX-2, and HER-2 based on binding energy and inhibition constant.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},384161,1790467925,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":55,"slug":118},9,"Religion & Spirituality","religion-spirituality",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":55,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},1236954412713,"https://us-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","molecules   \nArticle  \nChemical Profiling and Biological Activity of Psydrax dicoccos Gaertn  \nKamaraj Veeramuthu 1, Vishal Ahuja 2,3, Pushparaj Annadurai 4, Daniel A. Gideon 5, Balamurugan Sundarrajan 1, Marius Emil Rusu 6, *, Vinothkanna Annadurai 7 and Kandavel Dhandayuthapani 8, *  \nCitation: Veeramuthu, K.; Ahuja, V.; Annadurai, P.; Gideon, D.A.;  \nSundarrajan, B.; Rusu, M.E.;  \nAnnadurai, V.; Dhandayuthapani, K. Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn. Molecules 2023, 28, 7101. [https://](https://)[ ](https://)[doi.org/10.3390/molecules28207101](doi.org/10.3390/molecules28207101)  \nAcademic Editor: Francesco Cacciola  \nReceived: 14 September 2023  \nRevised: 9 October 2023  \nAccepted: 10 October 2023  \nPublished: 15 October 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Thanthai Periyar Government Arts and Science College (Autonomous), Bharathidasan University, Tiruchirappalli 620023, Tamil Nadu, India; [kamaraj2275@gmail.com](kamaraj2275@gmail.com) (K.V.); [drsbalamurugan2008@gmail.com](drsbalamurugan2008@gmail.com) (B.S.)  \n2 University Institute of Biotechnology, Chandigarh University, Mohali 140413, Punjab, India; [vahuja3@gmail.com](vahuja3@gmail.com)  \n3 University Centre for Research & Development, Chandigarh University, Mohali 140413, Punjab, India  \n4 C.P.R. Environmental Education Center, 1 Eldams Road, Alwarpet, Chennai 600018, Tamil Nadu, India; [pushpasaya10@gmail.com](pushpasaya10@gmail.com)  \n5 Department of Biochemistry, St. Joseph College, Bangalore 560025, Karnataka, India; [dnlndrwster@gmail.com](dnlndrwster@gmail.com)  \n6 Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania  \n7 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; [a.vinothcellbio@gmail.com](a.vinothcellbio@gmail.com)  \n8 Department of Botany, Government Arts College for Men, Nandanam, University of Madras, Chennai 600035, Tamil Nadu, India  \n* Correspondence: [rusu.marius@umfcluj.ro](rusu.marius@umfcluj.ro) (M.E.R.); [kandavel1976@gmail.com](kandavel1976@gmail.com) (K.D.)  \nAbstract: Breast cancer is one of the deadliest diseases in women with a mortality rate of 6.6% . Adverse effects of synthetic drugs have directed research toward safer alternatives such as natural compounds. This study focused on Psydrax dicoccos Gaertn, an evergreen tree abundantly distributed in Tamil Nadu (India) for its possible application against breast cancer cells. P. dicoccos leaf methanol extract, found within a wide range of phytochemicals, demonstrated cytotoxic effects against MCF7 breast cancer cells at IC 50 of 34 􀀖g/mL. The extract exhibited good antioxidant activities against DPPH􀀏 (62%) and ABTS􀀏+ (80%), as well as concentration-dependent (100–800 􀀖g/mL) anti-inflammatory potential of 18–60% compared to standards, ascorbic acid or aspirin, respectively. Moreover, even low extract concentrations (10 􀀖g/mL) inhibited the growth of Escherichia coli (1.9 􀀆 0.6 mm) and Pseudomonas aeruginosa (2.3 􀀆 0.7 mm), thus showing high antimicrobial and antiinflammatory potential. GC-MS and LC-MS analyses identified 31 and 16 components, respectively, of which selected compounds were used to evaluate the interaction between key receptors (AKT-1, COX-2, and HER-2) of breast cancer based on binding energy (DG) and inhibition constant (Ki) . The results indicate that bioactive compounds from P. dicoccos have potential against breast cancer cells, but further evaluations are needed.  \nKeywords: Psydrax dicoccos; phytochemistry; antioxidant; cytotoxicity; anti-inflammatory; GC-MS; LC-M","cbCaitxP76aAYAb4","https://ap.wps.com/l/cbCaitxP76aAYAb4","pdf",4047791,17,"English","# Abstract\n# Introduction\n## Breast cancer background and receptor categories\n## Akt1, oxidative stress, and signaling inhibition\n## Limitations of synthetic therapies and interest in phytomedicine","[{\"question\":\"What plant material and extract were evaluated in the study?\",\"answer\":\"The study evaluated Psydrax dicoccos Gaertn evergreen tree leaves, using a methanol extract for biological testing.\"},{\"question\":\"How did the extract perform against breast cancer cells?\",\"answer\":\"The methanol extract exhibited cytotoxic effects against MCF7 breast cancer cells with an IC50 value reported as 34 μg/mL.\"},{\"question\":\"Which biochemical assays and computational methods were used to assess activity?\",\"answer\":\"Antioxidant activity was measured using DPPH and ABTS assays, anti-inflammatory potential was assessed across concentrations, and GC-MS/LC-MS were used for component identification. Molecular docking evaluated interactions with AKT-1, COX-2, and HER-2 based on binding energy and inhibition constant.\"}]","Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn | PDF",1790261460,43]