[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-356552-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-356552-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","chek2-germline-variants-in-b-cell-precursor-acute-lymphoblastic-leukemia-findings-in-mexican-pediatric-patients","CHEK2 Germline Variants in B-cell Precursor Acute Lymphoblastic Leukemia - Findings in Mexican Pediatric Patients","","Study characterizes deleterious CHEK2 germline variants as moderate-penetrance risk alleles and evaluates whether they relate to childhood-onset B-cell precursor acute lymphoblastic leukemia (pre-B ALL). Next-generation exome sequencing identifies CHEK2 variants in Mexican children with pre-B ALL, supported by comparison with MCPS control datasets and a literature review. Structural and in silico analyses predict functional impacts, including effects on protein dimerization for the recurrent p.Leu236Pro variant. Results provide preliminary evidence of CHEK2-associated pre-B ALL predisposition in specific populations.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/chek2-germline-variants-in-b-cell-precursor-acute-lymphoblastic-leukemia-findings-in-mexican-pediatric-patients/356552/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/chek2-germline-variants-in-b-cell-precursor-acute-lymphoblastic-leukemia-findings-in-mexican-pediatric-patients/356552.png","ImageObject",300,407,{"name":42,"@type":43},"Jake","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-27","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the main objective of this study on CHEK2 variants and pre-B ALL?","Question",{"text":62,"@type":63},"To describe the mutational profile of CHEK2 germline variants in Mexican children diagnosed with pre-B ALL and review the CHEK2 variant landscape in pediatric pre-B ALL.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were CHEK2 germline variants identified in the participating children?",{"text":67,"@type":63},"Next-generation exome sequencing was performed on 73 Mexican children with pre-B ALL, followed by genetic feature assessment for CHEK2 variant carriers.",{"name":69,"@type":60,"acceptedAnswer":70},"What evidence links the CHEK2 p.Leu236Pro variant to pre-B ALL predisposition?",{"text":71,"@type":63},"In comparison with the Indigenous Mexican stratum of the MCPS database, the p.Leu236Pro variant showed an association with pre-B ALL predisposition (unadjusted OR 5.48; 95% CI 1.34–22.37). Structural modeling also suggests steric hindrance affecting protein dimerization.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},356552,1790468076,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Original Research PUBLISHED 16 March 2026  \nDOI 10.3389/fonc.2026.1751793  \nOPEN ACCESS  \nEDITED BY  \nSharon R. Pine,  \nUniversity of Colorado Anschutz Medical Campus, United States  \nREVIEWED BY  \nDeyanira Escalante Bautista, IMSS, Mexico  \nHossein Neamatzadeh,  \nShahid Sadoughi University of Medical Sciences and Health Services, Iran  \n*CORRESPONDENCE  \nPatricia Pe´ rez-Vera  \n [pperezvera@yahoo.com](pperezvera@yahoo.com)  \nRECEIVED 22 November 2025  \nREVISED 13 February 2026  \nACCEPTED 23 February 2026  \nPUBLISHED 16 March 2026  \nCITATION  \nMartnez Anaya D, Fern´andez Hern´andez L, Valladares Coyotecatl M, Ju´arez Figueroa U, Dean M, Ju´arez Villegas L, Zapata Tarre´s M, Lo´pez Santiago N and Pe´ rez-Vera P (2026) CHEK2 germline variants in B-cell precursor acute lymphoblastic leukemia:  \nfindings in Mexican pediatric patients. Front. Oncol. 16:1751793 .  \ndoi: 10.3389/fonc.2026.1751793  \nCOPYRIGHT  \n© 2026 Martnez Anaya, Fern´andez Hern´andez, Valladares Coyotecatl, Ju´arez Figueroa, Dean, Ju´arez Villegas, Zapata Tarre´ s, Lo´ pez Santiago and Pe´ rez-Vera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCHEK2 germline variants in B-cell precursor acute lymphoblastic leukemia: findings in Mexican pediatric patients  \nDaniel Mart ´ınez Anaya 1,2, Liliana Fern´andez Hern´andez 3, Marian Valladares Coyotecatl 1, Ulises Ju´arez Figueroa 4, Michael Dean 5, Luis Ju´arez Villegas 6, Marta Zapata Tarr´es 7, Norma Lo´ pez Santiago 8 and Patricia P´erez-Vera 1*  \n1 Laboratorio de Gene´ tica y C´ancer, Instituto Nacional de Pediatra, Mexico City, Mexico, 2 Posgrado en Ciencias Biológicas, Unidad de Posgrado, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico, 3 Laboratorio de Biologa Molecular, Instituto Nacional de Pediatra, Mexico City, Mexico, 4 Laboratorio de Citogene´tica, Instituto Nacional de Pediatra, Mexico  \nCity, Mexico, 5 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States, 6Servicio de Hemato-Oncologa, Hospital Infantil de Me´ xico Federico Go´mez, Mexico City, Mexico, 7Comisio´n Coordinadora de Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City, Mexico, 8Servicio de Hematologa, Instituto Nacional de Pediatra, Mexico City, Mexico  \nBackground: Deleterious CHEK2 germline variants (GVs) are moderatepenetrance risk alleles that predispose individuals to adult-onset neoplasms. However, their association with childhood-onset cancers, such as B-cell precursor acute lymphoblastic leukemia (pre-B ALL), remains unexplored.  \nAim: To describe the mutational profile of CHEK2 GVs in a cohort of Mexican children diagnosed with pre-BALL and review the mutational landscape of CHEK2 GVs in children with pre-B ALL.  \nMethods: Next-generation exome sequencing was performed on 73 Mexican children with pre-B ALL. Clinical and genetic features of CHEK2 GVs carriers have been described. Associations between CHEK2 GVs and predisposition to pre–BALL were evaluated using the MCPS population datasets as control groups. In addition, a literature review was conducted to investigate the potential link between CHEK2 germline variants and pre-B ALL. Finally, an in silico analysis was performed using bioinformatic tools and protein modeling to predict the functional and structural effects of these variants.  \nResults: CHEK2 GVs were identified in four patients with high-risk pre-B ALL, two carried likely pathogenic variants (2.7%) and two carried variants of uncertain significance (2 .7%) . Three of these pat","cbCaib8JvfJWM593","https://ap.wps.com/l/cbCaib8JvfJWM593","pdf",6036914,"English","# Background\n# Aim\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What is the main objective of this study on CHEK2 variants and pre-B ALL?\",\"answer\":\"To describe the mutational profile of CHEK2 germline variants in Mexican children diagnosed with pre-B ALL and review the CHEK2 variant landscape in pediatric pre-B ALL.\"},{\"question\":\"How were CHEK2 germline variants identified in the participating children?\",\"answer\":\"Next-generation exome sequencing was performed on 73 Mexican children with pre-B ALL, followed by genetic feature assessment for CHEK2 variant carriers.\"},{\"question\":\"What evidence links the CHEK2 p.Leu236Pro variant to pre-B ALL predisposition?\",\"answer\":\"In comparison with the Indigenous Mexican stratum of the MCPS database, the p.Leu236Pro variant showed an association with pre-B ALL predisposition (unadjusted OR 5.48; 95% CI 1.34–22.37). Structural modeling also suggests steric hindrance affecting protein dimerization.\"}]","CHEK2 Germline Variants in B-cell Precursor Acute Lymphoblastic Leukemia - Findings in Mexican Pediatric Patients | PDF",1790125932,25]