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Provides detection time guidance, kit contents, required equipment, sensitivity ranges versus EU/CODEX MRLs, and cross-reactivity/interference information. Includes storage conditions, reagent handling, and instructions for negative and positive controls to monitor performance and run testing consistently.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/charm-arla-test-for-raw-commingled-cow-goat-and-sheep-milk-operators-manual/661975/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/charm-arla-test-for-raw-commingled-cow-goat-and-sheep-milk-operators-manual/661975.png","ImageObject",300,407,{"name":92,"@type":93},"Putri","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-10-28",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the Charm ARLA Test detect and how fast are results obtained?","Question",{"text":112,"@type":113},"It detects beta-lactam and tetracycline drugs in raw commingled milk. Results are reported in 2 minutes for cow milk, and in 3 minutes for goat or sheep milk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What storage conditions are required for the test strips and positive tablets?",{"text":117,"@type":113},"Store ARLA test strips and positive tablets refrigerated at defined cold ranges (0 to 7°C or 0 to 4.5°C for US certified labs). Reconstituted positive control and negative control have specific refrigerated stability windows as provided.",{"name":119,"@type":110,"acceptedAnswer":120},"How are negative and positive controls prepared and used?",{"text":121,"@type":113},"Use beta-lactam and tetracycline negative raw commingled milk as the negative control, and MRLBLTET/TET Positive Tablet to prepare the positive control. Controls are used with defined volumes in the procedure and are intended for performance monitoring.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},661975,1793192219,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":46},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","| |  | Operator’s Manual:\u003Cbr>Charm® ARLA Test for Raw Commingled Cow, Goat, and Sheep Milk |  |  |  |\n| --- | --- | --- | --- | --- | --- |\n| Kit Information |  |  |  |  |  |\n| Introduction\u003Cbr>The Charm ARLA Test is an immunoreceptor assay utilizing ROSA ® (Rapid One Step Assay) lateral flow technology. Beta-lactams or tetracyclines interact with colored beads in the lateral flow test strip, and the color intensity in the test and control zones is measured by the Charm EZ® . The Charm ARLA Test detects beta-lactam and tetracycline drugs in 2 minutes for cow milk (or in 3 minutes for goat milk or for sheep milk) . The test is designed for use by dairy, intake, laboratory, field, and regulatory personnel. |  |  |  |  |  |\n| Kit Contents and Materials Needed |  |  |  |  |  |\n| Supplied with Kits |  | Disposables |  | Equipment |  |\n| 􀁸 ARLA Test Strips\u003Cbr>􀁸 MRLBLTET/TET Positive Tablets (4 ppb Penicillin G and 100 ppb Oxytetracycline)\u003Cbr>􀁸 Operator’s Manual |  | 􀁸 Pipet Tips or\u003Cbr>􀁸 ROSA-Pipets |  | 􀁸 ROSA Incubator (56°C)\u003Cbr>􀁸 Charm EZ\u003Cbr>􀁸 Printer (optional)\u003Cbr>􀁸 300 µl Pipet (optional) |  |\n| Charm ROSA equipment available only from Charm Sciences Inc.\u003Cbr>For details and ordering information see Order Codes and Kit Contents. |  |  |  |  |  |\n| Sensitivity and Selectivity\u003Cbr>Beta-lactam and tetracycline-free raw milk yields negative results at least 99% of the time.\u003Cbr>Table 1. Sensitivity – Detection Ranges in Cow Milk at 0 to 7°C |  |  |  |  |  |\n| Beta-lactam Drug | Detection Range† (ppb) | EU / CODEX MRL (ppb*) | Beta-lactam Drug | Detection Range† (ppb) | EU / CODEX MRL (ppb*) |\n| Amoxicillin | 2 to 3 | 4 | Cloxacillin | 3 to 5 | 30 |\n| Ampicillin | 2 to 3 | 4 | Dicloxacillin | 3 to 5 | 30 |\n| Cefacetrile | 20 to 40 | 125 | Oxacillin | 6 to 8 | 30 |\n| Cefalonium | 1 to 2 | 20 | Penicillin G | 0.75 to 1.5 | 4 / 4 |\n| Cefazolin | 20 to 40 | 50 | Tetracycline Drug | Detection Range† (ppb) | EU / CODEX MRL (ppb*) |\n| Cefoperazone | 1 to 3 | 50 |  |  |  |\n| Cefquinome | 15 to 25 | 20 | Chlortetracycline | 50 to 100 | 100 / 100 |\n| Ceftiofur and Metabolite^ | 40 to 70 | 100 / 100 | Oxytetracycline | 50 to 100 | 100 / 100 |\n| Cephapirin | 4 to 6 | 60§ | Tetracycline | 10 to 30 | 100 / 100 |\n| * parts per billion or µg/L\u003Cbr>^ Ceftiofur parent drug sensitivity is at levels approximately ¼ those reported in the table.\u003Cbr>† Positive at least 95% of the time. Sensitivity of antibiotic detection in goat and sheep milk is less than that in cow milk.\u003Cbr>§ U.S. Tolerance is 20 ppb cephapirin. |  |  |  |  |  |\n| Storage\u003Cbr>Store ARLA test strips and Positive Tablets refrigerated (defined as 0 to 7°C or 0 to 4.5°C for US certified labs) . See Reagents and Storage for details. |  |  |  |  |  |\n\n\n| Interferences and Cross Reactivity\u003Cbr>There are no known interferences from drugs at 100 ppb in the following animal drug families: aminoglycosides, amphenicols, fluoroquinolones, macrolides/lincosamides, nitrofurans, sulfa\u003Cbr>drugs/sulfonamides, or chlorothiazide, dexamethasone, dipyrone, flunixin, furosemide, ivermectin, novobiocin, oxytocin, PABA, phenylbutazone, trichlormethiazide, and thiabendazole. Other beta-lactam and tetracycline drugs are detected; cefalexin at 1000 to 2000 ppb, cefuroxime at 100 to 300 ppb, nafcillin at 100 to 200 ppb, and piperacillin at 3 to 5 ppb. There are no interferences from somatic cells at 106\u003Cbr>SCC/ml or bacteria at 3 x 105 CFU/ml. |\n| --- |\n| Training |\n| 􀁸 Equipment setup and use can be self-taught from the manual.\u003Cbr>􀁸 Proficiency samples are available for validation.\u003Cbr>􀁸 For questions contact your local representative or Charm Sciences at +1.978.687.9200 or [support@charm.com](support@charm.com). |\n| Reagents and Storage |\n| Test kits are not required to be shipped refrigerated. |\n| Test Strips\u003Cbr>􀁸 Store test strips refrigerated in tightly closed supplied container.\u003Cbr>􀁸 To open test strip container, remove and save plastic lid with foil lined foam insert to reseal container. Lift foil tab and peel foil ","cbCaiu76JMvUVQ8C","https://ap.wps.com/l/cbCaiu76JMvUVQ8C","pdf",473140,"English","# Introduction\n# Kit Contents and Materials Needed\n# Sensitivity and Selectivity\n# Storage\n# Interferences and Cross Reactivity\n# Training\n# Reagents and Storage\n## Negative Control\n## Positive Control\n# Long-Term Sample and Control Storage","[{\"question\":\"What does the Charm ARLA Test detect and how fast are results obtained?\",\"answer\":\"It detects beta-lactam and tetracycline drugs in raw commingled milk. Results are reported in 2 minutes for cow milk, and in 3 minutes for goat or sheep milk.\"},{\"question\":\"What storage conditions are required for the test strips and positive tablets?\",\"answer\":\"Store ARLA test strips and positive tablets refrigerated at defined cold ranges (0 to 7°C or 0 to 4.5°C for US certified labs). Reconstituted positive control and negative control have specific refrigerated stability windows as provided.\"},{\"question\":\"How are negative and positive controls prepared and used?\",\"answer\":\"Use beta-lactam and tetracycline negative raw commingled milk as the negative control, and MRLBLTET/TET Positive Tablet to prepare the positive control. Controls are used with defined volumes in the procedure and are intended for performance monitoring.\"}]","Charm ARLA Test for Raw Commingled Cow, Goat, and Sheep Milk - Operator’s Manual | PDF"]