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Intermediate filaments form dense perinuclear networks and can extend to the cortex, contributing to mechanical cushioning, organelle positioning, apoptosis, migration, adhesion, and cytoskeletal interactions. This review consolidates keratin-family basics, KRT80’s essential role in neoplasms, and its therapeutic potential. Evidence links high KRT80 expression with enhanced cancer-cell proliferation, invasiveness, and migration, while prognosis effects and clinical indices vary, requiring broader, more systematic studies across cancers to define shared regulators and pathways.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/characters-of-krt80-and-its-roles-in-neoplasms-diseases-review/377005/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/characters-of-krt80-and-its-roles-in-neoplasms-diseases-review/377005.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is KRT80 and what cellular role does it play?","Question",{"text":113,"@type":114},"KRT80 encodes a component of intracellular intermediate filaments involved in cytoskeleton assembly. Intermediate filaments contribute to mechanical cushioning, organelle positioning, apoptosis, migration, and adhesion.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How is KRT80 linked to neoplastic diseases?",{"text":118,"@type":114},"In many neoplastic diseases, high KRT80 expression has been established, and its regulation of cancer-cell biological functions is implicated. KRT80 can enhance proliferation, invasiveness, and migration of cancer cells.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are additional studies needed on KRT80 in clinical settings?",{"text":122,"@type":114},"Effects of KRT80 on prognosis and clinically relevant indices are not extensively studied and may differ across studies of the same cancer. The review highlights the need for more clinically relevant, systematic work across more cancers to identify common regulators and signaling pathways.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377005,1790309130,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","DOI: 10. 1002/cam4 .6040  \nREVIEW  \nCharacters ofKRT80 and its roles in neoplasms diseases  \nXin-Yuan Wei1  | Jie Zhao2 | Hao-Bin Tong1 | Shang-Jie Cheng1 | Na He2 | Fei-Xue Song2  \n1Lanzhou University Second Hospital, Lanzhou, Gansu, China 2Department of oncology, Lanzhou University Second Hospital, Lanzhou,  \nGansu, China  \nCorrespondence  \nNa He and Fei-Xue Song, Department of oncology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.  \n[Email:](Email: hen18@lzu.edu.cn)[ hen18@lzu.edu.cn](Email: hen18@lzu.edu.cn); [13639336037@139.com](13639336037@139.com)  \nFunding information  \n\"Cuiying Technology Innovation\"Project of Lanzhou University Second Hospital, Grant/Award Number: CY2019-QN17; 2020 Gansu Provincial Higher Education Innovation Fund Project, Grant/Award Number: 2020B- 042; 2022 National Student Innovation and Entrepreneurship Training Program, Grant/Award Number:  \n202210730183; Cuiying Clinical Project of Lanzhou University Second Hospital, Grant/Award Number: CY2018-BJ11; Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital, Grant/ Award Number: CYXZ2020-20; Gansu Province Health Industry Scientific Research Program, Grant/Award Number: GSWSKY2018-31  \nAbstract  \nBackground: KRT80 is a human epithelial intermediate filament type II gene; its expression product is a component of intracellular intermediate filaments (IFs) and is involved in the assembly of the cytoskeleton. There is evidence that IFs form a dense network mainly in the perinuclear area, but they can also reach the cortex. They are essential for mechanical cushioning of cells, organelle positioning, cell apoptosis, migration, adhesion, and interactions with other cytoskeletal components. Humans possess 54 functional keratin genes, and KRT80 is one of the more unique genes. It is widely expressed in almost all epithelial cells, although it is structurally more similar to type II hair keratins than to type II epithelial keratins.  \nAim: In this review, we summarize the basic facts about the keratin family and KRT80, the essential role ofKRT80 in neoplasms, and its potential as a therapeutic target. We hope that this review will inspire researchers to at least partially focus on this area.  \nResult: In many neoplastic diseases, the high expression status of KRT80 and its role in regulating the biological functions of cancer cells have been well established. KRT80 can effectively enhance the proliferation, invasiveness and migration of cancer cells. However, the effects of KRT80 on prognosis and clinically relevant indices in patients with various cancers have not been extensively studied, and even opposite conclusions have been reached in different studies of the same cancer. Based on this, we should add more clinically relevant studies to clarify the prospect of clinical application of KRT80 . Many researchers have made great progress in studying the mechanism of action of KRT80 . However, their studies should be extended to more cancers to find common regulators and signaling pathways ofKRT80 in different cancers. KRT80 may have far-reaching effects on the human body, and this marker may play a crucial role in the function of cancer cells and the prognosis of cancer patients, so it has a promising future in the field of neoplasms.  \nNa He and Fei-Xue Song have contributed equally to this work.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.  \nConclusion: In neoplastic diseases, KRT80 is overexpressed in many cancersand plays an essential role in promoting proliferation, migration, invasiveness and poor prognosis. The mechanisms of KRT80 functions in cancer have been partially elucidated, suggesting that KRT80 is a potentially useful cancer therapeutic target. However, more sy","cbCaidOwLWNp5rOt","https://ap.wps.com/l/cbCaidOwLWNp5rOt","pdf",1292897,13,"English","# Abstract\n## Background\n## Aim\n## Result\n## Conclusion\n# Introduction","[{\"question\":\"What is KRT80 and what cellular role does it play?\",\"answer\":\"KRT80 encodes a component of intracellular intermediate filaments involved in cytoskeleton assembly. Intermediate filaments contribute to mechanical cushioning, organelle positioning, apoptosis, migration, and adhesion.\"},{\"question\":\"How is KRT80 linked to neoplastic diseases?\",\"answer\":\"In many neoplastic diseases, high KRT80 expression has been established, and its regulation of cancer-cell biological functions is implicated. KRT80 can enhance proliferation, invasiveness, and migration of cancer cells.\"},{\"question\":\"Why are additional studies needed on KRT80 in clinical settings?\",\"answer\":\"Effects of KRT80 on prognosis and clinically relevant indices are not extensively studied and may differ across studies of the same cancer. The review highlights the need for more clinically relevant, systematic work across more cancers to identify common regulators and signaling pathways.\"}]","Characters of KRT80 and its roles in neoplasms diseases - review | PDF",1790222653,33]