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Using a cohort of 10,767 SOTR patients from the Mount Sinai Health System and 10,000 nontransplant nonimmunosuppressed controls, researchers compared the prevalence of dermatologic and systemic comorbidities and calculated relative risks with adjusted P values. Transplant recipients showed higher odds of skin cancers and autoimmune blistering and other autoimmune and inflammatory bowel diseases, while common inflammatory dermatoses differed minimally.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/characterization-of-inflammatory-skin-conditions-and-autoimmune-conditions-in-solid-organ-transplant-patients/433023/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/characterization-of-inflammatory-skin-conditions-and-autoimmune-conditions-in-solid-organ-transplant-patients/433023.png","ImageObject",300,407,{"name":42,"@type":43},"Mafia Boss","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What study cohort was used to compare transplant patients with controls?","Question",{"text":63,"@type":64},"The analysis used 10,767 solid organ transplant recipients from an institutional Mount Sinai database and compared them with 10,000 nontransplant nonimmunosuppressed controls.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which conditions showed the strongest increase in transplant recipients?",{"text":68,"@type":64},"Transplant recipients had significantly increased odds of skin cancers (including squamous cell carcinoma, basal cell carcinoma, and melanoma) and autoimmune blistering diseases such as bullous pemphigoid.",{"name":70,"@type":61,"acceptedAnswer":71},"Did common inflammatory skin conditions also increase markedly after transplant?",{"text":72,"@type":64},"No. Atopic dermatitis, acne vulgaris, and rosacea showed minimal differences between transplant recipients and controls.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},433023,1790765946,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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patients at a large metropolitan academic center  \nTo the Editor: Solid organ transplantation has become increasingly common, with nearly 50,000 transplants performed in the United States in 2024 alone.1 This coincides with a growing population of organ transplant recipients requiring dermatologic care. The increased risk of cutaneous squamous cell carcinoma has been well documented in the literature.2 Beyond this, solid organ transplant recipients are also susceptibleto arange ofother dermatologic conditions. These include skin infections, drug toxicity, immune-driven inflammatory reactions, and benign conditions.3 However, despite their clinical relevance, the burden and characteristics of inflammatory skin diseases in solid organ transplant recipients are not well established.  \nWe leveraged a diverse cohort of 10,767 SOTR patients in an institutional database from the Mount Sinai Health System in New York City to compare transplant patients and random nonimmunosuppressed controls. We compared the prevalence of each dermatologic and systemic comorbidity between organ transplant recipients and healthy controls.  \nRelative risks, 95% CIs, and Benjamini—Hochberg adjusted P values were calculated. The latter being to account for multiple comparisons for the burden of multiple comorbidities.  \nPatients with lupus diagnosis prior to transplant were excluded to avoid confounding post-transplant results.  \nWe analyzed 10,767 transplant patients and compared them to 10,000 nontransplant controls (Table I) . Compared to controls, transplant recipients had significantly increased odds of various comorbidities, most notably skin cancers (squamous cell carcinoma, basal cell carcinoma, and melanoma) and autoimmune blistering diseases (bullous pemphigoid) . Lupus also showed consistently elevated odds (systemic lupus erythematosus, cutaneous/discoid lupus, and lupus unspecified) (Fig 1) . Increased odds were seen for connective tissue diseases (Sj€ogren’s syndrome and systemic sclerosis) and inflammatory bowel disease (Crohn’s disease, ulcerative colitis) . By contrast, common inflammatory dermatoses like atopic dermatitis, acne vulgaris, androsacea showed minimal differences between groups. This pattern was strongest in kidney and liver recipients but evident across all transplant groups (Supplementary Fig 1, available via Mendeley at [https://data.mendeley.com/datasets/4wzt8t3cy5/1](https://data.mendeley.com/datasets/4wzt8t3cy5/1)) .  \nWhile immunosuppression in solid organ transplant recipients has traditionally been viewed as  \nTable I. Patient characteristics and demographics in transplant patients and controls  \n\n|  | Category | Control N = 10000 | Transplant N = 10767 | P value |\n| --- | --- | --- | --- | --- |\n| Age (mean [SD]) Sex | Female Male | 47.73 (21 .04)\u003Cbr>5599 (56 .0)\u003Cbr>4401 (44 .0) | 51.67 (17 .23)\u003Cbr>4199 (39 .0)\u003Cbr>6566 (61 .0) | \u003C.001\u003Cbr>\u003C.001 |\n| Race/ethnicity | White\u003Cbr>American Indian or Alaska Native Asian\u003Cbr>Black or African-American Hispanic\u003Cbr>Native Hawaiian or Pacific Islander Other* | 2927 (29 .3)\u003Cbr>9 (0 . 1)\u003Cbr>636 (6 .4)\u003Cbr>934 (9 .3)\u003Cbr>1114 (11 . 1)\u003Cbr>10 (0 . 1)\u003Cbr>4370 (43 . 7) | 3577 (33 .2)\u003Cbr>11 (0 . 1)\u003Cbr>806 (7 .5)\u003Cbr>2069 (19 .2)\u003Cbr>1792 (16 .6)\u003Cbr>16 (0 . 1)\u003Cbr>2496 (23 .2) | \u003C.001 |\n| Insurance | Medicaid\u003Cbr>Medicare Private insurance Self-pay\u003Cbr>Other | 1244 (12 .4)\u003Cbr>1633 (16 .3)\u003Cbr>5104 (51 .0)\u003Cbr>120 (1 .2)\u003Cbr>1899 (18 .9) | 1176 (10 .9)\u003Cbr>4572 (42 .5)\u003Cbr>2605 (24 .2)\u003Cbr>59 (0 .5)\u003Cbr>2355 (21 .8) | \u003C.001 |\n| *Other (other/patient declined/unknown) . |  |  |  |  |\n\n© 2025 The Author(s). Published by Elsevier Inc. on behalf of the American Academy of Dermatology, Inc. This is an open access article under the CC BY-NC-ND license ([http://creativecommons](http://creativecommons).  \norg/licenses/by-nc-nd/4.0/).  \nJAAD INT FEBRUARY 2026 271  \n272 Research Letter JAAD INT FEBRUARY 2026  \nFig ","cbCaifAVCIQXtdKh","https://ap.wps.com/l/cbCaifAVCIQXtdKh","pdf",413954,"English","# Comparative cohort design\n## Comorbidity prevalence comparisons\n# Statistical analysis approach\n## Relative risks and adjusted P values\n# Key findings and clinical implications\n## Skin cancers, autoimmune diseases, and inflammatory bowel disease\n## Minimal differences in common inflammatory dermatoses","[{\"question\":\"What study cohort was used to compare transplant patients with controls?\",\"answer\":\"The analysis used 10,767 solid organ transplant recipients from an institutional Mount Sinai database and compared them with 10,000 nontransplant nonimmunosuppressed controls.\"},{\"question\":\"Which conditions showed the strongest increase in transplant recipients?\",\"answer\":\"Transplant recipients had significantly increased odds of skin cancers (including squamous cell carcinoma, basal cell carcinoma, and melanoma) and autoimmune blistering diseases such as bullous pemphigoid.\"},{\"question\":\"Did common inflammatory skin conditions also increase markedly after transplant?\",\"answer\":\"No. Atopic dermatitis, acne vulgaris, and rosacea showed minimal differences between transplant recipients and controls.\"}]","Characterization of inflammatory skin conditions and autoimmune conditions in solid organ transplant patients | PDF",1790662392]