[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328319-105":59,"doc-detail-328319-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","characteristics-of-the-immune-environment-in-prostate-cancer-as-an-adjunct-to-immunotherapy","Characteristics of the immune environment in prostate cancer as an adjunct to immunotherapy","","Tumor microenvironment signaling critically shapes carcinogenesis and progression in prostate cancer, yet the immune cell infiltration patterns driving prognosis remain insufficiently resolved. Using TCGA and GEO prostate cancer cohorts, merged with the ComBat algorithm, immune cell infiltration profiles are characterized via unsupervised clustering and principal component analysis to derive an immune infiltration score. Distinct immune patterns correlate with clinical features, pathways, and mutation load. High-score subtypes show poorer outcomes and suggest precision immunotherapy guidance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/characteristics-of-the-immune-environment-in-prostate-cancer-as-an-adjunct-to-immunotherapy/328319/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/characteristics-of-the-immune-environment-in-prostate-cancer-as-an-adjunct-to-immunotherapy/328319.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of the study?","Question",{"text":112,"@type":113},"To characterize immune cell infiltration patterns in prostate cancer and determine whether these patterns provide prognostic value and support immunotherapy-guided treatment decisions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which datasets and analytical approaches are used?",{"text":117,"@type":113},"The study uses TCGA and GEO prostate cancer datasets, merged with the ComBat algorithm, then applies unsupervised clustering and principal component analysis to estimate immune infiltration patterns and scores.",{"name":119,"@type":110,"acceptedAnswer":120},"How do the identified immune infiltration patterns relate to prognosis?",{"text":121,"@type":113},"The clustering reveals distinct immune infiltration profiles linked to clinical characteristics and biological pathways; higher immune infiltration score subtypes are associated with worse prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328319,1790198348,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","DOI: 10.1002/hsr2.2148  \nORIG INA L RESEARCH    \nCharacteristics of the immune environment in prostate cancer as an adjunct to immunotherapy  \nXinhai Yin1 | Yadong Wu2 | Jukun Song2   \n1Department of Oral and Maxillofacial Surgery, Guizhou Provincial People's Hospital, Guiyang, China  \n2Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Guizhou Medical University, Guiyang, China  \nCorrespondence  \nJukun Song, Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Guizhou Medical University, Guiyang 550002, China.  \nEmail: [songjukun@163.com](songjukun@163.com)  \nAbstract  \nBackground and Aims: The tumor microenvironment (TME) exerts an important role in carcinogenesis and progression. Several investigations have suggested that immune cell infiltration (ICI) is of high prognostic importance for tumor progression and patient survival in many tumors, particularly prostate cancer. The pattern of immune infiltration of PCa, on the other hand, has not been thoroughly understood. Methods: The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) datasets on PCa were obtained, and several datasets were merged into one data set using the “ComBat” algorithm. The ICI profiles of PCa patients were then tobe uncovered by two computer techniques. The unsupervised clustering method was utilized to identify three ICI patterns in tumor samples, and Principal Component Analysis (PCA) was conducted to estimate the ICI score.  \nResults: Three different clusters of three ICIs were identified in 1341 PCa samples, which also correlated with different clinical features/characteristics and biological pathways. Patients with PCa are classified into high and low subtypes based on the ICI scores extracted from immune‐associated signature genes. High ICI score subtypes are associated with a worse prognosis, which may intrigue the activation of cancer‐related and immune‐related pathways such as pathways involving Toll‐like receptors, T‐cell receptors, JAK‐STAT, and natural killer cells. The ICI score was linked to tumor mutation load and immune/cancer‐relevant signaling pathways, which explain prostate cancer's poor prognosis.  \nConclusion: The findings of this study not only advanced our knowledge of the mechanism of immune response in the prostate tumor microenvironment but also provided a novel biomarker, that is, the ICI score, for disease prognosis and guiding precision immunotherapy.  \nKEYWO R DS  \nimmune cell infiltration, principal component analysis, prostate cancer, tumor microenvironment  \nThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2024 The Author(s) . Health Science Reports published by Wiley Periodicals LLC.  \nHealth Sci. Rep. 2024;7:e2148 . [https://doi.org/10.1002/hsr2.2148](https://doi.org/10.1002/hsr2.2148)  \n[wileyonlinelibrary.com/journal/hsr2](wileyonlinelibrary.com/journal/hsr2)  \n1 of 15  \n1 | INTRODUCTION  \nProstate cancer remains one of the leading worldwide health concerns in males. Each year, over 230,000 new instances of prostate cancer are discovered in the US, and about 195,000 radical prostatectomy procedures are carried out. 1,2 According to the latest data from the American Cancer Society (ACS), the relative survival rates for prostate cancer patients at 5, 10, and 15 years are 99%, 98%, and 96% respectively The percentage of men without prostate cancer in the overall population.3 These data indicate that the extensive majority of new presentations are with locally advanced diseases, representing significant healthcare and substantial economic burdens. Up to 35% of men who have radical prostatectomy will develop PSA recurrence within 10 years of surgery, which is often brought on by micro‐metastatic disease after surgery, eventhough","cbCais8M89j6Ts2y","https://ap.wps.com/l/cbCais8M89j6Ts2y","pdf",4752795,15,"English","# Introduction\n## Background on prostate cancer and tumor microenvironment\n## Rationale for immune infiltration characterization\n# Abstract\n## Background and aims\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What is the main objective of the study?\",\"answer\":\"To characterize immune cell infiltration patterns in prostate cancer and determine whether these patterns provide prognostic value and support immunotherapy-guided treatment decisions.\"},{\"question\":\"Which datasets and analytical approaches are used?\",\"answer\":\"The study uses TCGA and GEO prostate cancer datasets, merged with the ComBat algorithm, then applies unsupervised clustering and principal component analysis to estimate immune infiltration patterns and scores.\"},{\"question\":\"How do the identified immune infiltration patterns relate to prognosis?\",\"answer\":\"The clustering reveals distinct immune infiltration profiles linked to clinical characteristics and biological pathways; higher immune infiltration score subtypes are associated with worse prognosis.\"}]","Characteristics of the immune environment in prostate cancer as an adjunct to immunotherapy | PDF",1789979316,38]