[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342643-105":59,"doc-detail-342643-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","characteristics-of-cancer-stem-cells-and-their-potential-role-in-endometrial-cancer","Characteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer","","Endometrial cancer is among the most common gynaecological tumours in developing countries, and cancer stem cells are proposed to drive its development. These highly tumorigenic cells share key stem-like traits such as unlimited proliferation, self-renewal, multi-potential differentiation, aggressiveness, invasion, recurrence, and resistance to chemo- and endocrine therapies. Frequently activated pathways include Wnt/β-catenin, Hedghog and Notch1. Surface markers such as CD24, CD40, CD44, CD9, CD133 and CD166 correlate with increased tumorigenicity, yet no universal marker is established.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/characteristics-of-cancer-stem-cells-and-their-potential-role-in-endometrial-cancer/342643/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/characteristics-of-cancer-stem-cells-and-their-potential-role-in-endometrial-cancer/342643.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role are cancer stem cells proposed to play in endometrial cancer?","Question",{"text":112,"@type":113},"Cancer stem cells are suggested to contribute to the development of endometrial cancer. They may influence how the cancer grows and spreads and are linked to aggressiveness, recurrence, and therapy resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which signalling pathways are most frequently activated in endometrial cancer stem cells?",{"text":117,"@type":113},"Wnt/β-catenin, Hedghog, and Notch1 are described as the most frequently activated pathways in endometrial cancer stem cells.",{"name":119,"@type":110,"acceptedAnswer":120},"Are there universal biomarkers for identifying endometrial cancer stem cells?",{"text":121,"@type":113},"Several markers (including CD24, CD40, CD44, CD9, CD133 and CD166) have been identified, and higher expression is associated with enhanced tumorigenicity. However, the text states there is no strong evidence for any universal marker.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342643,1790101943,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","cancers   \nReview  \nCharacteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer  \nKarolina Fra˛szczak 1 and Bartłomiej Barczy ´nski 2, *  \nCitation: Fra˛szczak, K.; Barczy ´nski, B. Characteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer. Cancers 2024, 16, 1083. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16061083  \nAcademic Editor: Georgios Androutsopoulos  \nReceived: 31 January 2024  \nRevised: 29 February 2024  \nAccepted: 1 March 2024  \nPublished: 7 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 1st Chair and Department of Oncological Gynaecology and Gynaecology, Medical University in Lublin, 20-081 Lublin, Poland; [karolina.fraszczak@umlub.pl](karolina.fraszczak@umlub.pl)  \n2 Department of Obstetrics and Pathology of Pregnancy, Medical University in Lublin, 20-081 Lublin, Poland  \n* [Correspondence: bartlomiej.barczynski@umlub.pl](Correspondence: bartlomiej.barczynski@umlub.pl); Tel.: +48-504108558  \nSimple Summary: In this manuscript, the characteristics of cancer stem cells and their potential role in endometrial cancer are explored. An understanding of the mechanisms behind cancer stem cells in endometrial cancer is crucial because these cells potentially play a key role in how the cancer grows and spreads. The authors aim to review the most recent data concerning cancer stem cells in endometrial cancer, especially biomarkers which could enable identification and prognosis. The determination of signalling pathways crucial for the functioning of cancer stem cells could help with the design of effective treatment strategies.  \nAbstract: Endometrial cancer is one of most common types of gynaecological tumours in developing countries. It has been suggested that cancer stem cells play an important role in the development of endometrial cancer. These are a subset of highly tumorigenic cells with similar features to normal stem cells (unlimited proliferation, multi-potential differentiation, self-renewal, aggressiveness, invasion, recurrence, and chemo-and endocrine therapy resistance) . Wnt/β-catenin, Hedghog, and Notch1 are the most frequently activated pathways in endometrial cancer stem cells. The presence of cancer stem cells is associated with the resistance to chemotherapy caused by different mechanisms. Various markers, including CD24, CD40, CD44, CD9, CD133, and CD 166, have been identified on the surface of these cells. A higher expression of such markers translates into enhanced tumorigenicity. However, there is no strong evidence showing that any of these identified markers can be used as the universal marker for endometrial cancer stem cells. Growing data from genomic and proteomic profiling shed some light on the understanding of the molecular basis of cancers in humans and the role of cancer stem cells. However, there is much left to discover. Therefore, more studies are needed to fully uncover their functional mechanisms in order to prevent the development and recurrence of cancer, as well as to enhance treatment effectiveness.  \nKeywords: cancer stem cells; endometrial cancer; CD133; CD117; CD44  \n1. Introduction  \nEndometrial cancer is the most common type of gynaecological hormone-dependent tumour in developing countries [1] . According to American Cancer Society estimates, approximately 67,880 new cases of uterine (including endometrial) cancers will be diagnosed in 2024, and 13,250 women will die from this disease in United States [2] . In turn, according to GLOBOSCAN, the age-standardised incidence of endometrial cancer and patient mortality was 8.7 and 1.8 in 2020 [3] .  \nThe risk of endom","cbCaicFBEcicyH9W","https://ap.wps.com/l/cbCaicFBEcicyH9W","pdf",1492325,"English","# Introduction\n## Epidemiology and risk factors\n## Clinical presentation and diagnosis\n## Treatment and prognosis\n# Cancer stem cells in endometrial cancer\n## Proposed role in growth and spread\n## Activated signalling pathways\n## Markers and therapeutic resistance","[{\"question\":\"What role are cancer stem cells proposed to play in endometrial cancer?\",\"answer\":\"Cancer stem cells are suggested to contribute to the development of endometrial cancer. They may influence how the cancer grows and spreads and are linked to aggressiveness, recurrence, and therapy resistance.\"},{\"question\":\"Which signalling pathways are most frequently activated in endometrial cancer stem cells?\",\"answer\":\"Wnt/β-catenin, Hedghog, and Notch1 are described as the most frequently activated pathways in endometrial cancer stem cells.\"},{\"question\":\"Are there universal biomarkers for identifying endometrial cancer stem cells?\",\"answer\":\"Several markers (including CD24, CD40, CD44, CD9, CD133 and CD166) have been identified, and higher expression is associated with enhanced tumorigenicity. However, the text states there is no strong evidence for any universal marker.\"}]","Characteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer | PDF",1790047531]