[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-442113-en":59,"doc-seo-442113-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":79},442113,962088121634,"supergirl","https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections","Respiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants are linked to higher morbidity and mortality, yet hospital presentations and clinical courses are insufficiently described. A multicenter retrospective cohort study evaluated hospitalized patients with hematologic malignancy or HCT from 2019–2023, comparing presentations, care processes, and outcomes across viral pathogens. Among 385 hospitalizations, death or discharge to hospice occurred in 14% and did not differ significantly by pathogen, while SARS-CoV-2 showed higher radiographic lung edema assessment and pathogen-specific differences in antibiotics and corticosteroid use.","Open Forum Infectious Diseases  \nMAJOR ARTICLE  \nCharacteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections  \nZulfiqar A. Lokhandwala,1,2, Brenna Park-Egan,3 RavneetWaraich,4, Colleen A. McEvoy,5,6 Andrew P. Michelson,5,7 Alice F. Bewley,5,8, Lynne Strasfeld,9 Rachel Cook,10,11 Brandon Hayes-Lattin,10,11 Catherine L. Hough,3 and Patrick G. Lyons3,11,  \n1School of Medicine, Oregon Health & Science University, Portland, Oregon, USA, 2School of Public Health, Oregon Health & Science University-Portland State University, Portland, Oregon, USA, 3Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA, 4Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA, 5Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA, 6Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA, 7Data Science, and Biostatistics, Institute for Informatics, Washington University School of Medicine, Saint Louis, Missouri, USA, 8Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, Missouri, USA, 9Division of Infectious Diseases, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA, 10Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA, and 11Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA  \n\n| Background. Respiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants (HCTs) are associated with increased morbidity and mortality. However, the hospital presentations and courses of these infections remain under-described.\u003Cbr>Methods. We performed a multicenter retrospective cohort study of hospitalized patients with hematologic malignancy or HCTat 2 comprehensive cancer centers between January 2019 and June 2023. We included all patients with acute viral respiratory infection (identified based on a constellation of test results and objective physiology), comparing clinical presentations, care processes, and patient outcomes across pathogens; the primary outcome was the composite of hospital death or discharge to hospice.\u003Cbr>Results. We evaluated 385 hospitalizations from 346 unique patients, 162 (42%) of which were for SARS-CoV-2 infection. The primary outcome of death or discharge to hospice occurred in 54 (14%) encounters and did not significantly differ across pathogens (P = .4) . We observed higher radiographic assessment of lung edema scores in SARS-CoV-2 infection (median 28 [interquartile range 22–32]) compared with other viral infections (5 [2–9], P \u003C .001) . Care process differences across pathogens included antibiotic (SARS-CoV-2 98/162 [60%], respiratory syncytial virus [RSV] 17/28 [61%], rhino/enterovirus 59/91 [65%], influenza 22/33 [67%], and others 69/86 [80%], P = .034) and corticosteroid use (≥ 40 mg prednisone equivalents daily: SARS-CoV-2 99/ 162 [61%], RSV 10/28 [36%], rhino/enterovirus 30/91 [33%], influenza 9/33 [27%], and others 37/86 [43%], P \u003C .001) .\u003Cbr>Interpretation. Among hospitalized patients with hematologic malignancies or HCTs, acute viral respiratory infections display similar initial physiology and outcomes regardless of pathogen. These findings may have implications for clinical practice.\u003Cbr>Keywords. hematologic malignancies; pneumonia; respiratory infections; viral infection. |  |\n| --- | --- |\n| Respiratory infections cause substantial morbidity and mortality among patients with hematologic malignancies, including hematopoietic cell transplant (HCT) recipients [ 1–5]. Even prior to the Coronavirus Disease 2019 pandemic, viral pathogens were increasingly recognized as a substantial contributor to the burden of acute respiratory failure in this ","cbCaidyqkTw3Kp2Q","https://ap.wps.com/l/cbCaidyqkTw3Kp2Q","pdf",807688,"English","en",105,"# Background\n# Methods\n# Results\n# Interpretation\n# Keywords","[{\"question\":\"What was the primary outcome of the study?\",\"answer\":\"The primary outcome was the composite of hospital death or discharge to hospice.\"},{\"question\":\"How many hospitalizations and patients were evaluated?\",\"answer\":\"The study evaluated 385 hospitalizations from 346 unique patients.\"},{\"question\":\"Did outcomes differ significantly across respiratory viral pathogens?\",\"answer\":\"No. The primary outcome occurred in 14% of encounters and did not significantly differ across pathogens.\"}]","Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections | PDF",1790699077,25,{"code":4,"msg":81,"data":82},"ok",{"site_id":74,"language":73,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"characteristics-and-outcomes-of-patients-with-hematologic-malignancies-hospitalized-with-respiratory-viral-infections","",{"@graph":86,"@context":138},[87,101,121],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,99],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":98},"https://docshare.wps.com/document/healthcare/",3,{"item":100,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/characteristics-and-outcomes-of-patients-with-hematologic-malignancies-hospitalized-with-respiratory-viral-infections/442113/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":73,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/characteristics-and-outcomes-of-patients-with-hematologic-malignancies-hospitalized-with-respiratory-viral-infections/442113.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":91,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":118,"interactionType":119,"userInteractionCount":14},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What was the primary outcome of the study?","Question",{"text":128,"@type":129},"The primary outcome was the composite of hospital death or discharge to hospice.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"How many hospitalizations and patients were evaluated?",{"text":133,"@type":129},"The study evaluated 385 hospitalizations from 346 unique patients.",{"name":135,"@type":126,"acceptedAnswer":136},"Did outcomes differ significantly across respiratory viral pathogens?",{"text":137,"@type":129},"No. The primary outcome occurred in 14% of encounters and did not significantly differ across pathogens.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":74},1790742393]