[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-606474-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-606474-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","chapter-21-nanospanlastics-as-a-promising-nanovesicle-for-drug-delivery","Chapter 21 - Nanospanlastics as a promising nanovesicle for drug delivery","","Chapter 21 introduces nanospanlastics as surfactant-based deformable nanocarriers designed for improved drug delivery. It explains how their components can enhance membrane permeability, flexibility, recyclability, security, and nonimmunogenic behavior compared with conformist liposomes. The chapter discusses entrapment of hydrophilic and lipophilic drugs, improved stability and bioavailability, and examples involving EGCG, including delayed decomposition and better absorption with lower toxicity. It also reviews limitations of conventional carriers and motivates more deformable systems for topical permeation. Finally, Boswellia resin constituents such as BAs and AKBA are presented for anti-inflammatory and related therapeutic potential, while issues of low aqueous solubility and oral bioavailability are highlighted.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/chapter-21-nanospanlastics-as-a-promising-nanovesicle-for-drug-delivery/606474/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/chapter-21-nanospanlastics-as-a-promising-nanovesicle-for-drug-delivery/606474.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-10-16",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What are nanospanlastics and why are they considered promising for drug delivery?","Question",{"text":63,"@type":64},"Nanospanlastics are surfactant-based deformable nanocarriers. They are described as recyclable, secure, distortable, and nonimmunogenic, with vesicular membranes that increase permeability and flexibility across biological membranes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do nanospanlastics affect drug stability and bioavailability?",{"text":68,"@type":64},"Both hydrophilic and lipophilic drugs can be entrapped within nanovesicular systems. Permeability and stability of encapsulated drugs are said to improve, and drug transport to target positions in a continued manner increases bioavailability.",{"name":70,"@type":61,"acceptedAnswer":71},"What limitations are noted for conventional carriers like niosomes and liposomes?",{"text":72,"@type":64},"During passage through diverse biological membranes, conventional carriers are described as lacking deformability and having a nonelastic or rigid character. The chapter states that this limits permeability and flexibility compared with deformable systems.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},606474,1792691294,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":107},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Chapter 21  \nNanospanlastic as a promising nanovesicle for drug delivery  \nSaima Muzammil1, Aliza Mazhar2, Derya Karata Yeni3, Rahat Andleeb2, Asma Ashraf2, Mirza Imran Shehzad4, Nimrah Zafar2 and Maryam Mazhar5  \n1Department of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan, 2Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan, 3Veterinary Control Central Research Institute, Bacterial Disease Laboratory, Ankara, Turkey, 4Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan, 5Department of Zoology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan  \n21.1 Introduction to the nanospanlastics  \nThe two researchers Kakkar and Kaur framed splanstics, which are surfactant-based deformable nanocarriers. EAs and nonionic surfactants are the main constituents of splanstics.1 The undermining factor for the nanocarriers vesicular membranes are EAs, which increase their permeability and flexibility across the biological membranes.2 The Nanospanlastics are recyclable, secure, distortable, and nonimmunogenic nanovesicles. Furthermore, they were chemically more constant than conformist liposomes.2  \nBoth hydrophilic and lipophilic drugs could be entrapped by the nanovesicular system like as, niosomes and liposomes, which consisted of nonpolar and polar parts. Both permeability and stability of encapsulated drugs could also be improved by nanovesicles.3 Moreover, they could transport drugs to their objective positions in a continued or organized way, which increased the bioavailability.4 According to a research by increasing the bioavailability and stability of epigallocatechin gallate (EGCG) using nanovesicles encapsulation.5 It had stated that the decomposition of EGCGin vitro could be proficiently delayed by nanopolisomes. Besides, it was discovered by.6 The niosomal formulations of (2) EGCG and (1) catechin displayed improved absorption, lower toxicity, and higher stability as compared to the free drug. However, during passageway through diverse biological membranes, these conventional carriers lack deformability and have a nonelastic character.7  \nMany approaches had been operated. In order to improve the permeability of drugs through the stratum corneum (SC) in drug topical deliverance different approaches had been used such as conventional colloidal carriers, like niosomes, liposomes, microemulsions, or hard nanoparticles of lipids. However, during channel through the biological membranes, these carriers lack deformability and flexibility and had a rigid nature. Consequently, current learning had been explored to improve the pliability of these conformist carriers in order to improve their permeability via various skin layers.8  \nThe affordable and valuable source of drugs potential was natural products that could be utilized as essential for the cure of numerous ailments. The species Boswellia of the family Berceraceae is an assembly of trees present in the Middle East, Northern Association: Eman Mazyed Faculty of Pharmacy, Department of Pharmaceutical Technology, Kafrelsheikh University, POB 33516, Kafrelsheikh, Egypt Tel 120 100 3484508 Email [eman_mazyad@pharm.kfs.edu](eman_mazyad@pharm.kfs.edu). eg Drug Design, Development, and Therapy Dove Press open access to scientific and medical research Open Access Full Text Article submit your manuscript | [http://](http://www.dovepress.com Drug Design)[www.dovepress.com](http://www.dovepress.com Drug Design)[ Drug Design](http://www.dovepress.com Drug Design), Development and Therapy 2020:14 3697􀀁3721 3697 [https://doi.org/10.2147/DDDT.S265167](https://doi.org/10.2147/DDDT.S265167) DovePress r 2020 Badria and Mazyed. This work was licensed and issued by Medical Dove Press Limited. By gaining access to the work you hereby admitted, the terms offered to the work are accurately attributed, and the nonprofitable functions of the work are allowed without any additional approval from Medica","cbCaimRjyrvqIsKB","https://ap.wps.com/l/cbCaimRjyrvqIsKB","pdf",217348,16,"English","# 21.1 Introduction to the nanospanlastics\n## Nanospanlastics composition and membrane interactions\n## Drug encapsulation, stability, and bioavailability\n## Limits of conventional nanocarriers and need for deformability\n## Natural products and Boswellia resin constituents","[{\"question\":\"What are nanospanlastics and why are they considered promising for drug delivery?\",\"answer\":\"Nanospanlastics are surfactant-based deformable nanocarriers. They are described as recyclable, secure, distortable, and nonimmunogenic, with vesicular membranes that increase permeability and flexibility across biological membranes.\"},{\"question\":\"How do nanospanlastics affect drug stability and bioavailability?\",\"answer\":\"Both hydrophilic and lipophilic drugs can be entrapped within nanovesicular systems. Permeability and stability of encapsulated drugs are said to improve, and drug transport to target positions in a continued manner increases bioavailability.\"},{\"question\":\"What limitations are noted for conventional carriers like niosomes and liposomes?\",\"answer\":\"During passage through diverse biological membranes, conventional carriers are described as lacking deformability and having a nonelastic or rigid character. The chapter states that this limits permeability and flexibility compared with deformable systems.\"}]","Chapter 21 - Nanospanlastics as a promising nanovesicle for drug delivery | PDF",1792184479]