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This secondary analysis evaluates whether reductions in adipose tissue compartment volumes relate to hepatic histologic improvement, using prospectively acquired data from the multicenter randomized placebo-controlled FLINT trial of obeticholic acid. Adult participants with paired baseline and end-of-treatment liver biopsies and abdominal MRI at 72 weeks were analyzed, assessing MRI-derived adipose volumes and NASH histologic endpoints.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/changes-in-abdominal-adipose-tissue-depots-assessed-by-mri-correlate-with-hepatic-histologic-improvement-in-non-alcoholic-steatohepatitis-research-article-summary/272517/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/changes-in-abdominal-adipose-tissue-depots-assessed-by-mri-correlate-with-hepatic-histologic-improvement-in-non-alcoholic-steatohepatitis-research-article-summary/272517.png","ImageObject",300,407,{"name":92,"@type":93},"Gelato","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-15",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What relationship does the study examine between adipose tissue and NASH?","Question",{"text":112,"@type":113},"It examines whether reductions in adipose tissue compartment volumes measured by MRI correlate with hepatic histologic improvement in NASH.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which trial data are used in this analysis?",{"text":117,"@type":113},"The study uses prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial evaluating obeticholic acid in NASH treatment.",{"name":119,"@type":110,"acceptedAnswer":120},"What participants were included and what assessments were performed?",{"text":121,"@type":113},"Adult participants with paired liver biopsies and abdominal MRI exams at baseline and end-of-treatment (72 weeks) were included, with adipose tissue volumes obtained by MRI.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},272517,1789465716,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":129,"read_time":144,"preview_page_count":4},19241457091524,"https://us-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","UC San Diego  \nUC San Diego Previously Published Works  \nTitle  \nChanges in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis  \nPermalink  \n[https://escholarship.org/uc/item/4fz662jw](https://escholarship.org/uc/item/4fz662jw)  \nJournal  \nJournal of Hepatology, 78(2)  \nISSN  \n0168-8278  \nAuthors  \nShen, Wei  \nMiddleton, Michael S Cunha, Guilherme Met al.  \nPublication Date  \n2023-02-01  \nDOI  \n10.1016/j.jhep.2022.10.027  \nPeer reviewed  \n[eScholarship.org](eScholarship.org) Powered by the California Digital Library  \nUniversity of California  \nAuthor Manuscr ipt Author Manuscr ipt Author Manuscr ipt Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>J Hepatol. Author manuscript; available in PMC 2024 February 01. |\n| --- | --- |\n\nPublished in final edited form as:  \nJ Hepatol. 2023 February ; 78(2): 238–246. doi:10.1016/j.jhep.2022.10.027 .  \nChanges in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholicsteatohepatitis  \nWei Shen 1,2,3 , Michael S. Middleton4 , Guilherme M. Cunha5 , Timoteo I. Delgado4 , Tanya Wolfson6 , Anthony Gamst6,7 , Kathryn J. Fowler4 , Adina Alazraki8 , Andrew T. Trout9 , Michael A. Ohliger10 , Shetal N. Shah 11 , Mustafa R. Bashir12,13,14 , David E. Kleiner15 , Rohit Loomba 16 , Brent A Neuschwander-Tetri 17 , Arun J. Sanyal 18 , Jane Zhou 1 , Claude B. Sirlin4,* , Joel E. Lavine 1,2,*  \n1 Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA;  \n2 Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center; NY, USA;  \n3Columbia Magnetic Resonance Research Center (CMRRC), Columbia University;  \n4Liver Imaging Group, Department of Radiology, UCSD School of Medicine, San Diego, CA, USA;  \n5 Department of Radiology, University of Washington, Seattle, WA;  \n6Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputer Center at UCSD, San Diego, CA, USA;  \n7 Department of Mathematics, UCSD, San Diego, CA, USA; USA;  \n8 Emory University School of Medicine, Department of Radiology and Imaging Sciences and Children’s Healthcare of Atlanta, Atlanta, GA, USA;  \n9 Department of Radiology, Cincinnati Children’s Hospital Medical Center and Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA;  \n10 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA;  \nCorrespondence to: Wei Shen, MD, Department of Pediatrics and Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University, Director, Image Analysis Core Laboratory, Obesity Nutrition Research Center, Columbia Magnetic Resonance sequlcoCenterntributi(CMon tRotRC), WShe work@nicoroumuthir[a.edu](a.edu).  \nAuthor contributions: substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data: WS, JL, CS, TIW, MSM, GMC, TD, and DEK; 2) drafting the article or revising it critically for important intellectual content: WS, MSM, GMC, TD, TIW, AG, KJF, AA, ATT, MO, SNS, MRB, DEK, RL, BAN-T, AJS, JZ, CS, and, JL; 3) final approval of the version to be published: WS, MSM, GMC, TD, TIW, AG, KJF, AA, ATT, MO, SNS, MRB, DEK, RL, BAN-T, AJS, JZ, CS, and, JL. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  \nClinical trial number: NCT01265498  \nAuthor Manuscr ipt Author Manuscr ipt Author ","cbCailBrl7nraaJD","https://ap.wps.com/l/cbCailBrl7nraaJD","pdf",1269460,25,"English","# Abstract\n## Background & Aims\n## Methods\n## Results","[{\"question\":\"What relationship does the study examine between adipose tissue and NASH?\",\"answer\":\"It examines whether reductions in adipose tissue compartment volumes measured by MRI correlate with hepatic histologic improvement in NASH.\"},{\"question\":\"Which trial data are used in this analysis?\",\"answer\":\"The study uses prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial evaluating obeticholic acid in NASH treatment.\"},{\"question\":\"What participants were included and what assessments were performed?\",\"answer\":\"Adult participants with paired liver biopsies and abdominal MRI exams at baseline and end-of-treatment (72 weeks) were included, with adipose tissue volumes obtained by MRI.\"}]","Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis - Research article summary | PDF",63]