[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-422413-105":59,"doc-detail-422413-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","challenges-of-ecmo-use-for-severe-trauma-a-narrative-review","Challenges of ECMO use for severe trauma: a narrative review","","Severe trauma patients face life-threatening complications such as acute respiratory failure and circulatory collapse, making extracorporeal membrane oxygenation (ECMO) a critical rescue option when conventional treatments fail. This narrative review synthesizes clinical evidence on ECMO for severe trauma, detailing indications, major complications, survival outcomes, and prognostic factors. It also highlights gaps in trauma-specific prediction models and outlines future directions for decision support, multicenter research, and standardized anticoagulation and infection control protocols.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/challenges-of-ecmo-use-for-severe-trauma-a-narrative-review/422413/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/challenges-of-ecmo-use-for-severe-trauma-a-narrative-review/422413.png","ImageObject",300,407,{"name":92,"@type":93},"Blue Pony","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which ECMO modalities are most commonly used in severe trauma, and for what conditions?","Question",{"text":112,"@type":113},"Veno-venous ECMO is primarily used for trauma-associated acute respiratory distress syndrome, while veno-arterial ECMO is used in cardiogenic shock and cardiac arrest management.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What survival rates are reported for VV ECMO and VA ECMO in severe trauma?",{"text":117,"@type":113},"Reported survival rates are 72.3% for veno-venous ECMO and 39.0% for veno-arterial ECMO.",{"name":119,"@type":110,"acceptedAnswer":120},"What major complications and prognostic factors are emphasized in the review?",{"text":121,"@type":113},"Major complications include infection, hemorrhage, and thrombosis, requiring coordinated prevention and management. Prognostic evaluation uses tools such as the New Injury Severity Score, Simplified Acute Physiology Score III, and Sequential Organ Failure Assessment, though trauma-specific models remain limited.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},422413,1790729623,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090760266,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Zhang et al. Hereditas (2026) 163:4 Hereditas  \n[https://doi.org/10.1186/s41065-025-00611-4](https://doi.org/10.1186/s41065-025-00611-4)  \nREVIEW Open Access  \nChallenges of ECMO use for severe trauma: a narrative review  \nXin-Liang Zhang 1, Ying-Qi Zhang 1, Zhi-Yong Hou2 and Wei Chen2*  \nAbstract  \nBackground Patients with severe trauma are at high risk of developing life-threatening complications, including acute respiratory failure and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) offers critical support when conventional therapies fail. This narrative review aimed to analyze the clinical application of ECMO in patients with severe trauma, focusing on indications, complications, prognostic factors, and future directions.  \nMethods A comprehensive literature search was conducted to identify studies published between January 2000 and April 2025. Sources included original research articles, systematic reviews, and meta-analyses, supplemented by relevant clinical guidelines and expert consensus statements pertaining to ECMO use in trauma care.  \nResults Veno-venous ECMO has been primarily utilized in patients with trauma-associated acute respiratory distress syndrome, while veno-arterial ECMO has been employed in the management of cardiogenic shock and cardiac arrest. Reported survival rates were 72. 3% for veno-venous ECMO and 39. 0% for veno-arterial ECMO. ECMO has also been used in patients with traumatic brain injury and those undergoing extracorporeal cardiopulmonary resuscitation, although randomized controlled trial data remain limited Major complications include infection, hemorrhage, and thrombosis, which require coordinated prevention and management strategies. Prognostic tools such as the New Injury Severity Score, Simplified Acute Physiology Score III, and Sequential Organ Failure Assessment score are used in clinical evaluation, though trauma-specific models are still lacking.  \nConclusion ECMO offers a supportive treatment modality in the management of patients with severe trauma. To improve clinical outcomes, further development of trauma-specific decision tools, multicenter studies, and standardized protocols for anticoagulation and infection control is necessary to support individualized care. Keywords Complication management, Extracorporeal membrane oxygenation, Individualized treatment, Prognostic factors, Severe trauma  \n*Correspondence: Wei Chen [weichen_hmu@126.com](weichen_hmu@126.com)  \n1Emergency Department, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050051, China  \n2Trauma Emergency Center, The Third Hospital of Hebei Medical University, No. 139, Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei Province 050051, China  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherwise stated in a credit line to the data.  \nZhang et al. Hereditas (2026) 163:4  \nBackground  \nAccording to the Global Burden ","cbCaicRvGpza2t6L","https://ap.wps.com/l/cbCaicRvGpza2t6L","pdf",1589695,14,"English","# Background\n# Methods\n# Results\n## ECMO modalities and reported survival\n## Complications and prognostic tools\n# Conclusion\n# Keywords","[{\"question\":\"Which ECMO modalities are most commonly used in severe trauma, and for what conditions?\",\"answer\":\"Veno-venous ECMO is primarily used for trauma-associated acute respiratory distress syndrome, while veno-arterial ECMO is used in cardiogenic shock and cardiac arrest management.\"},{\"question\":\"What survival rates are reported for VV ECMO and VA ECMO in severe trauma?\",\"answer\":\"Reported survival rates are 72.3% for veno-venous ECMO and 39.0% for veno-arterial ECMO.\"},{\"question\":\"What major complications and prognostic factors are emphasized in the review?\",\"answer\":\"Major complications include infection, hemorrhage, and thrombosis, requiring coordinated prevention and management. Prognostic evaluation uses tools such as the New Injury Severity Score, Simplified Acute Physiology Score III, and Sequential Organ Failure Assessment, though trauma-specific models remain limited.\"}]","Challenges of ECMO use for severe trauma: a narrative review | PDF",1790627263,35]