[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-329103-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-329103-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","challenges-and-opportunities-in-the-selective-degradation-of-organophosphorus-herbicide-glyphosate","Challenges and opportunities in the selective degradation of organophosphorus herbicide glyphosate","","Extensive and continuous environmental use of glyphosate threatens biological systems. Beyond accumulation in vivo, its key degradation intermediate, aminomethylphosphonic acid (AMPA), affects the environment and organisms, including inducing chromosomal aberrations in fish and cancer-related effects in human erythrocytes. Because avoiding AMPA formation during complete glyphosate degradation is increasingly important, a focused mini-review summarizes recent (since 2018) selective degradation strategies. It covers synthesis routes and the selective degradation mechanisms, and highlights remaining challenges to guide further research.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/challenges-and-opportunities-in-the-selective-degradation-of-organophosphorus-herbicide-glyphosate/329103/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/challenges-and-opportunities-in-the-selective-degradation-of-organophosphorus-herbicide-glyphosate/329103.png","ImageObject",300,407,{"name":42,"@type":43},"Rowan","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-13","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is selective degradation of glyphosate considered important?","Question",{"text":63,"@type":64},"Widespread glyphosate use poses serious biological threats. A major reason is that complete degradation can generate AMPA, a more stable and toxic intermediate, so strategies that avoid AMPA formation are needed.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is AMPA and how does it relate to glyphosate risk?",{"text":68,"@type":64},"AMPA is the main degradation intermediate of glyphosate. Research indicates higher stability than glyphosate and links to biological effects such as chromosomal aberration in fish and canceration in human erythrocytes.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the review focus on regarding recent advances?",{"text":72,"@type":64},"The mini-review focuses on selective degradation approaches developed since 2018, summarizing synthesis routes and the selective degradation mechanisms while outlining future challenges.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},329103,1791111520,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","iScience  \nll  \nOPEN ACCESS  \nPerspective  \nChallenges and opportunities  \nin the selective degradation of organophosphorus herbicide glyphosate  \nLei Jin, 1 Yingping Huang,1 Liqun Ye, 1 Di Huang,1,* and Xiang Liu 1,*  \nSUMMARY  \nThe wide and continuous usage of glyphosate in the environment poses a serious threat to biological systems. Besides the accumulation of glyphosate in vivo, a growing body of research has revealed that aminomethylphosphonic acid (AMPA), the main degradation intermediate of glyphosate, has significant environmental and biological influences by inducing chromosome aberration of fish and canceration of human erythrocyte. Therefore, the development of new strategies avoiding the generation of the toxic AMPA intermediate during the full degradation of glyphosate is becoming of high importance. Herein, we provide a mini-review that includes the most recent advances in the selective degradation of glyphosate avoiding the generation of AMPA in the last several years from 2018. The developments of the selective degradation of glyphosate, highlighting its synthesis and selective degradation mechanism, are summarized here. This review intends to attract more attention from researchers toward this area and to emphasize the recent developments of selective degradation of glyphosate in highlighting future challenges.  \nINTRODUCTION  \nIn 1950, N-(phosphonomethyl)glycine was first synthesized by the Swiss chemist Henri Martin, at Cilag pharmaceutical company, but itwas not found to be useful at the time.1 In 1970, Hamm and Franz discovered its excellent herbicidal activity and named it glyphosate.2 The herbicidal activity of glyphosate is attributed to its inhibition of shikimic acid pathway, which breaks the photosynthesis of plants, thereby achieving the effect of herbicide.3 Since there is no shikimic acid pathway in animals and humans, glyphosate was originally considered as a completely nontoxic herbicide.4  \nTo date, glyphosate has been used as a broad-spectrum herbicide for more than 50 years and is registered for use in more than 130 countries.5 However, the widespread use of glyphosate in the environment poses a serious threat to biological systems.6 The main degradation intermediate of glyphosate (including the natural degradation and advanced oxidation process), aminomethylphosphonic acid (AMPA), which shows higher stability than glyphosate, is widely found in plant sediments, surface, and groundwater.7 In addition, the toxicity of AMPA has also recently been found to be higher than that of glyphosate. A growing body of research has revealed that glyphosate and AMPA may induce chromosome aberration of fish and canceration of human erythrocyte.8 For instance, in 2022, Cheng and Zhang’s group found that glyphosate could affect the all-round development of zebrafish embryos, including decreased body length, hatching abnormalities, and mortality (Figure 1) .9 With continued exposure to glyphosate, zebrafish embryos show cardiac malformations, including rhythm disturbances, enlarged chambers, and thinned ventricular walls. In 2015, glyphosate was categorized by the International Agency for Research on Cancer as ‘‘carcinogenic to humans.’’10 As a new pollutant, the environmental content of glyphosate and its degradation process in wastewater treatment have aroused wide public concern.11–15 Degradation strategies, adopted to avoid the formation of AMPA during the full degradation of glyphosate, need to be developed urgently. Herein, we offer a review that includes the most recent advances in the selective elimination of glyphosate by avoiding the formation of toxic AMPA intermediate, summarizing developments in the selective degradation of glyphosate and highlighting its synthesis and selective degradation mechanism in last several years from 2018 . The review intends to introduce the fundamental principle and recent developments concerning the selectivity of degradation of glyphosate, to highlight future challenges, an","cbCaij4s9W5XuRGf","https://ap.wps.com/l/cbCaij4s9W5XuRGf","pdf",3433426,"English","# Summary\n# Introduction\n# Synthesis of glyphosate","[{\"question\":\"Why is selective degradation of glyphosate considered important?\",\"answer\":\"Widespread glyphosate use poses serious biological threats. A major reason is that complete degradation can generate AMPA, a more stable and toxic intermediate, so strategies that avoid AMPA formation are needed.\"},{\"question\":\"What is AMPA and how does it relate to glyphosate risk?\",\"answer\":\"AMPA is the main degradation intermediate of glyphosate. Research indicates higher stability than glyphosate and links to biological effects such as chromosomal aberration in fish and canceration in human erythrocytes.\"},{\"question\":\"What does the review focus on regarding recent advances?\",\"answer\":\"The mini-review focuses on selective degradation approaches developed since 2018, summarizing synthesis routes and the selective degradation mechanisms while outlining future challenges.\"}]","Challenges and opportunities in the selective degradation of organophosphorus herbicide glyphosate | PDF",1789982452,23]