[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-437020-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-437020-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cervical-intranodal-schwannoma-and-its-malignant-transformation-a-case-report-with-literature-review","Cervical Intranodal Schwannoma and Its Malignant Transformation - A Case Report With Literature Review","","A case report describes a rare malignant transformation of a cervical intranodal schwannoma in a 46-year-old man. The patient presented with a slow-growing, painless right-neck nodule and underwent surgical excision, with histopathology showing benign intranodal cellular schwannoma. Eighteen months later, the mass recurred at the same site and the second surgery identified malignant peripheral nerve sheath tumor (MPNST), confirming malignant transformation. The report emphasizes the need for early resection and careful histopathological follow-up.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cervical-intranodal-schwannoma-and-its-malignant-transformation-a-case-report-with-literature-review/437020/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cervical-intranodal-schwannoma-and-its-malignant-transformation-a-case-report-with-literature-review/437020.png","ImageObject",300,407,{"name":42,"@type":43},"Cart","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-05","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the initial diagnosis and treatment for the patient’s neck mass?","Question",{"text":63,"@type":64},"A slow-growing, painless right-neck nodule was excised, and histopathology initially confirmed a benign intranodal cellular schwannoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What confirmed the malignant transformation after recurrence?",{"text":68,"@type":64},"Eighteen months later, recurrence at the same site led to a second surgery where histopathology identified malignant peripheral nerve sheath tumor (MPNST), confirming malignant transformation.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is early surgical excision and thorough histopathological evaluation important?",{"text":72,"@type":64},"Although intranodal schwannomas are usually benign, they can rarely transform malignantly; early removal and careful pathology help detect and monitor malignant change in atypical nodal masses.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},437020,1790998269,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Clinical Case Reports  \nCASE REPORT  OPEN ACCESS   \nCervical Intranodal Schwannoma and Its Malignant Transformation: A Case Report With Literature Review  \nShahab Hussain1 | Zia Ullah Khan2 | Nazneen Liaqat1 | Syed Wajihullah Shah2  | Kainat Khan3 | Jibran Ikram4   \n1Khyber Teaching Hospital, Peshawar, Pakistan | 2Department of Medicine, Khyber Medical College, Peshawar, Pakistan | 3Department of Internal  \nMedicine, Lady Reading Hospital, Peshawar, Pakistan | 4Cleveland Clinic Foundation, Cleveland, Ohio, USA Correspondence: Jibran Ikram ([ikramj@ccf.org](ikramj@ccf.org))  \nReceived: 31 May 2025 | Revised: 3 November 2025 | Accepted: 21 December 2025  \nKeywords: lymphadenopathy | malignancy | neoplasm | recurrence | schwannoma  \nABSTRACT  \nThis case report highlights a rare malignant transformation of a cervical intranodal schwannoma in a 46-year-old man. The patient first came in with a slow-growing, painless nodule in the right neck. Surgical excision was performed and histopathological examinations revealed a benign intranodal cellular schwannoma. Eighteen months later, the mass recurred and a second surgery showed malignant peripheral nerve sheath tumor (MPNST) at the same site, confirming malignant transformation. This case adds to the limited knowledge of this rare event.  \n1 | Introduction  \nIntranodal schwannomas, also called neurilemmomas, are encapsulated primary mesenchymal tumors that arise within lymph nodes [1] . Although generally benign and nonmetastasizing, rapid growth or associated pain should prompt consideration of possible malignancy [2] . Schwannomas can be found in many anatomical sites, but their primary origin within lymph nodes is extremely rare. Histologically, distinguishing between spindle-cell lesions in lymph nodes is essential, as it requires careful evaluation due to the potential presence of metastatic disease [3] . Clinically, intranodal schwannomas are often asymptomatic and detected incidentally, typically during histopathological analysis of surgical specimens taken for other indications [4] .  \nWe report a patient with a right-sided neck mass, which was initially diagnosed as an intranodal schwannoma. This rare and exceptional case of malignant transformation highlights the need to consider the possibility of malignancy in schwannomasand emphasizes its importance in the differential diagnosis of atypical nodal masses.  \n2 | Case History/Examination  \nA 46-year-old male presented with a history of a slowly enlarging, painless right-sided neck mass that had been present for the last 2 years. He also reported multiple subcutaneous swellings on his back and abdomen. Physical examination revealed a large, mobile mass on the right side of his neck, extending from the clavicle to the mandible, with normal overlying skin (Figure 1) . MRI showed a complex mass measuring 11 × 8 cm in the right side of the neck, extending into the posterior triangle.  \n3 | Differential Diagnosis, Investigations and Treatment  \nThe patient had no clinical stigmata of neurofibromatosis type 1 (NF1), such as café-au-lait macules, axillary or inguinal freckling, Lisch nodules, or a family history suggestive of the disorder. Cutaneous and neurological examinations were otherwise unremarkable and no dedicated germline NF1 testing was performed, as the clinical phenotype did not meet diagnostic criteria. Swellings on the back and abdomen were clinically assessed  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.  \nClinical Case Reports, 2026; 14:e71801 1 of 6  \n[https://doi.org/10.1002/ccr3.71801](https://doi.org/10.1002/ccr3.71801)  \nKey Clinical Message  \nCervical intranodal schwannomas, although typically benign, may rarely undergo malignant transformation, presenting as recurrent or enl","cbCaiiK7kupxIHE5","https://ap.wps.com/l/cbCaiiK7kupxIHE5","pdf",855770,"English","# Introduction\n# Case History/Examination\n# Differential Diagnosis, Investigations and Treatment\n# Conclusions and Results (Outcomes and Follow-Up)","[{\"question\":\"What was the initial diagnosis and treatment for the patient’s neck mass?\",\"answer\":\"A slow-growing, painless right-neck nodule was excised, and histopathology initially confirmed a benign intranodal cellular schwannoma.\"},{\"question\":\"What confirmed the malignant transformation after recurrence?\",\"answer\":\"Eighteen months later, recurrence at the same site led to a second surgery where histopathology identified malignant peripheral nerve sheath tumor (MPNST), confirming malignant transformation.\"},{\"question\":\"Why is early surgical excision and thorough histopathological evaluation important?\",\"answer\":\"Although intranodal schwannomas are usually benign, they can rarely transform malignantly; early removal and careful pathology help detect and monitor malignant change in atypical nodal masses.\"}]","Cervical Intranodal Schwannoma and Its Malignant Transformation - A Case Report With Literature Review | PDF",1790679871,15]