[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-440586-105":59,"doc-detail-440586-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","cerebrovascular-cinematic-rendering-of-multisystemic-smooth-muscle-dysfunction-syndrome-read-online-free","Cerebrovascular cinematic rendering of multisystemic smooth muscle dysfunction syndrome - read online free","","Cinematic rendering of CTA is used to depict characteristic cerebrovascular findings in multisystemic smooth muscle dysfunction syndrome (MSMDS). The report evaluates a 45-year-old man with recurrent dizziness for 2 years, showing right frontal lobe infarction on MRI, right middle cerebral artery occlusion on MRA, and distinctive CTA features including internal carotid dilatation, distal intracranial stenosis/occlusion, and an abnormally straight arterial course. The authors highlight educational and preoperative planning value and discuss genetic confirmation via ACTA2 mutations.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cerebrovascular-cinematic-rendering-of-multisystemic-smooth-muscle-dysfunction-syndrome-read-online-free/440586/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cerebrovascular-cinematic-rendering-of-multisystemic-smooth-muscle-dysfunction-syndrome-read-online-free/440586.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What patient and clinical presentation does the document describe?","Question",{"text":113,"@type":114},"A 45-year-old man with multisystemic smooth muscle dysfunction syndrome (MSMDS) was referred for evaluation of recurrent dizziness lasting 2 years.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which imaging modalities and key findings are reported?",{"text":118,"@type":114},"MRI shows right frontal lobe cerebral infarction, enlarged bilateral ventricular trigones, and hypoplasia of the corpus callosum; MRA shows occlusion of the right middle cerebral artery; cinematic rendering of CTA highlights internal carotid dilatation, distal intracranial stenosis/occlusion, and an abnormally straight arterial course.",{"name":120,"@type":111,"acceptedAnswer":121},"What role is suggested for early diagnosis and treatment planning in MSMDS?",{"text":122,"@type":114},"Because MSMDS is progressive and patients are at risk for recurrent strokes, the document suggests neurosurgeons should suspect MSMDS in patients with characteristic cerebrovascular findings and prioritize early genetic investigations. Early surgical intervention may be considered in selected cases to prevent further neurological deterioration.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},440586,1791111341,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Open access Pictures of stroke and cerebral vasculature  \n Cerebrovascular cinematic rendering of  multisystemic smooth muscle  \ndysfunction syndrome  \nLinggen Dong  ,1,2 Guanglei Li,3 Ming Lv  1,2  \nTo cite: Dong L, Li G, Lv M. Cerebrovascular cinematic rendering of multisystemic smooth muscle dysfunction syndrome. Stroke & Vascular Neurology 2025;0 . doi:10 . 1136/ svn-2024-003872  \n► Additional supplemental material is published online only. To view, please visit the journal online ([https://doi.org/10.1136/](https://doi.org/10.1136/)[ ](https://doi.org/10.1136/)[svn-2024-003872](svn-2024-003872)) .  \nGL and ML contributed equally.  \nReceived 13 November 2024 Accepted 21 February 2025  \n© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.  \n1Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China  \n2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China  \n3Department of Neurological Intervention, The Second Hospital of Qinhuangdao, Hebei, China  \nCorrespondence to  \nDr Guanglei Li;  \n[liguanglei123@126.com](liguanglei123@126.com)  \nDr Ming Lv;  \n[dragontiger@163.com](dragontiger@163.com)  \nA 45-year-old man diagnosed with multisystemic smooth muscle dysfunction syndrome (MSMDS) was referred for the evaluation of recurrent dizziness that had persisted for 2 years. MRI revealed a right frontal lobe cerebral infarction, enlargement of the bilateral ventricular trigones and hypoplasia of the corpus callosum (figure 1A,B) . MRA showed occlusion of the right middle cerebral artery (figure 1C,D) . Cinematic rendering of CTA highlighted characteristic cerebrovascular manifestations of MSMDS: dilatation of the internal carotid artery from the cavernous to the clinoid segments, stenosis and occlusion of the distal intracranial circulation and an abnormally straight course of intracranial arteries (figure 2 , online supplemental video S1) .1 Cinematic rendering of CTA provides highly realistic  \nFigure 1 MRI and MRA imaging. (A) Diffusionweighted image showed right frontal lobe cerebral infarction (red arrow) and trigone of bilateral ventricles enlargement (white arrow) .(B) T1 axial section showed hypoplasia of the corpus callosum. (C) Coronal and (D) sagittal MRI showed occlusion of the M1 segment of the right middle cerebral artery.  \nFigure 2 Cinematic rendering of CTA images of cerebral angiography in orthostatic (A) and lateral (B) positions. Cinematic rendering of CTA clearly depicts the anatomic contours of the bilateral internal carotid arteries; the photorealistic images produced by cinematic rendering could help neurosurgeons better familiarise themselves with this rare disease and its characteristic cerebrovascular manifestations.  \n3D reconstructed images, enabling multiangle and multi-plane rotational visualisation of vascular structures. This technique offers significant educational value, aiding neurointerventionalists in preoperative planning and improving communication between neurosurgeons and patients.2 There are currently no standard indications for neurosurgical revascularisation for MSMDS, which may be due in part to the paucity of reported cases and the high risk of postoperative stroke in the limited number of cases.1 3 Nevertheless, given the progressive nature of MSMDS and the risk of recurrent strokes, early surgical intervention may be considered in selected cases to prevent further neurological deterioration. MSMDS is an autosomal dominant condition caused by a mutation in the ACTA2 gene.4 Neurosurgeons should suspect MSMDS in patients presenting with recurrent strokes and characteristic cerebrovascular findings, and early genetic investigations should be prioritised to confirm the diagnosis.5  \nOpen access   \nContributors LD drafted and edited the manuscript. ML provided funding and designed the study. GL ","cbCain9BsScRlAFr","https://ap.wps.com/l/cbCain9BsScRlAFr","pdf",551531,"English","# Case evaluation\n## Imaging findings (MRI and MRA)\n## Cinematic rendering of CTA\n## Clinical implications and management considerations","[{\"question\":\"What patient and clinical presentation does the document describe?\",\"answer\":\"A 45-year-old man with multisystemic smooth muscle dysfunction syndrome (MSMDS) was referred for evaluation of recurrent dizziness lasting 2 years.\"},{\"question\":\"Which imaging modalities and key findings are reported?\",\"answer\":\"MRI shows right frontal lobe cerebral infarction, enlarged bilateral ventricular trigones, and hypoplasia of the corpus callosum; MRA shows occlusion of the right middle cerebral artery; cinematic rendering of CTA highlights internal carotid dilatation, distal intracranial stenosis/occlusion, and an abnormally straight arterial course.\"},{\"question\":\"What role is suggested for early diagnosis and treatment planning in MSMDS?\",\"answer\":\"Because MSMDS is progressive and patients are at risk for recurrent strokes, the document suggests neurosurgeons should suspect MSMDS in patients with characteristic cerebrovascular findings and prioritize early genetic investigations. Early surgical intervention may be considered in selected cases to prevent further neurological deterioration.\"}]","Cerebrovascular cinematic rendering of multisystemic smooth muscle dysfunction syndrome - read online free | PDF",1790692591]