[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-289951-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-289951-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cerebral-metabolic-correlates-of-the-clinical-dementia-rating-scale-in-mild-cognitive-impairment","Cerebral Metabolic Correlates of the Clinical Dementia Rating Scale in Mild Cognitive Impairment","","Mild cognitive impairment (MCI) is an early, often prodromal condition preceding Alzheimer’s disease (AD). Imaging evidence indicates that regional cerebral metabolic deficits in AD-affected areas can predict later progression. In this study, 41 MCI patients underwent 18F-FDG PET to quantify regional glucose metabolism and assess clinical impairment using the Clinical Dementia Rating scale sum of boxes (CDR-SB). Voxel-wise regression (SPM2) showed a significant negative link between CDR-SB and right posterior cingulate glucose metabolism, independent of demographics, supporting metabolic correlates of MCI severity.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cerebral-metabolic-correlates-of-the-clinical-dementia-rating-scale-in-mild-cognitive-impairment/289951/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cerebral-metabolic-correlates-of-the-clinical-dementia-rating-scale-in-mild-cognitive-impairment/289951.png","ImageObject",300,407,{"name":42,"@type":43},"Grenda","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-17",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",17,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main goal of the study?","Question",{"text":63,"@type":64},"To examine how clinical impairment on the Clinical Dementia Rating (CDR-SB) relates to regional glucose metabolism measured by 18F-FDG PET in patients with mild cognitive impairment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was clinical impairment quantified?",{"text":68,"@type":64},"Using the Clinical Dementia Rating scale sum of boxes (CDR-SB), derived from six functional and cognitive domains with scores ranging from 0 to 3.",{"name":70,"@type":61,"acceptedAnswer":71},"What relationship did the regression analysis find?",{"text":72,"@type":64},"A significant negative association between CDR-SB and glucose metabolism in the right posterior cingulate gyrus, independent of age, gender, and years of school education.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},289951,1789638758,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":80,"read_time":144,"preview_page_count":4},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Cerebral Metabolic Correlates of the Clinical Dementia Rating Scale in Mild Cognitive Impairment  \nRobert Perneczky, MD, Julia Hartmann, MD, Timo Grimmer, MD, Alexander Drzezga, MD, and Alexander Kurz, MD  \nABSTRACT  \nMild cognitive impairment (MCI) is often a prodromal state of Alzheimer’s disease (AD) . Imaging studies have shown that metabolic deficits in cerebral regions known to be affected early by AD pathology are predictive of progression to AD. In the present article, the authors examine associations between clinical impairment (Clinical Dementia Rating scale sum of boxes [CDR-SB]) and regional deficits in glucose utilization in a sample of 41 patients with MCI, who underwent cerebral 18F-FDG PET for the measurement of regional glucose metabolism. A linear regression analysis with CDR-SB score as the independent variable and glucose metabolism as the dependent variable, adjusted for age, gender, and years of school education, was conducted in voxel-by-voxel fashion in SPM2 . The regression analysis revealed a significant negative association between CDR-SB score and glucose metabolism in the right posterior cingulate gyrus (P \u003C .001, uncorrected for multiple comparisons), which was independent from demographical variables. The authors conclude that clinical severity of impairments is already correlated with deficits in glucose metabolism in the stage of MCI. (J Geriatr Psychiatry Neurol 2007;20:84-88)  \nKeywords: clinical dementia rating; positron emission tomography; cerebral glucose metabolism; mild cognitive impairment; Alzheimer’s disease; dementia  \nThe syndrome of mild cognitive impairment (MCI) is defined by the impairment of memory and ofother cognitive domains not severe enough to interfere with basic activities of daily living, otherwise intact intellectual ability, and absence of dementia. MCI is clinically heterogeneous and etiologically nonspecific.1 Prospective studies have consistently demonstrated that the amnestic type  \nReceived May 10, 2006 . Received revised June 26, 2006 . Accepted for publication June 27, 2006 .  \nFrom the Departments of Psychiatry and Psychotherapy (Drs Perneczky, Hartmann, Grimmer, and Kurz) and Nuclear Medicine (Dr Drzezga), Technische Universität München, Germany.  \nThis study was funded partly by the Federal Ministry of Research and Education as part ofa national collaboration on dementia (Kompetenznetz Demenzen), grant No 01GI0420.  \nAddress correspondence to: Dr Robert Perneczky, MD, Psychiatrische Klinik der TU München, Zentrum für kognitive Störungen, Ismaningerstr.  \n22, 81675 München, Germany; e-mail: [robert.perneczky@lrz.tum.de](robert.perneczky@lrz.tum.de). DOI: 10.1177/0891988706297093  \nof MCI, that is, the type with impairment of memory, frequently but not exclusively represents a predementia stage of Alzheimer’s disease (AD) .2 Therefore, patients with amnestic MCI have an increased risk of developing dementia.3,4 However, in a substantial proportion of cases, MCI is nonprogressive or even reversible.5,6 Hence, individual prognosis at the stage of MCI is of utmost importance particularly with regard to the development of disease-modifying treatment strategies.  \nIn previous studies using 18F-fluoro-2-deoxy-glucose (18F-FDG) for the measurement of the regional cerebral metabolic rate of glucose utilization (rCMRglc) assessed by positron emission tomography (PET), we have demonstrated that one third of patients with amnestic MCI show areas of metabolic reduction in temporal, parietal, and/or posterior cingulate cortices as compared to controls.7 This pattern of hypometabolism is typical of AD8,9 and, if present in MCI, is associated with an increased probability of progression to AD.10,11  \nIn the present article, we examine whether the clinical severity of impairments in patients with MCI is associated  \n84 © 2007 Sage Publications  \nDownloaded [from](from jgp.sagepub.com)[ jgp.sagepub.com](from jgp.sagepub.com) at Technical University of Munich University Librar","cbCaitXKOIxzAL5Y","https://ap.wps.com/l/cbCaitXKOIxzAL5Y","pdf",104438,"English","# Abstract\n# Methods\n## Study Sample","[{\"question\":\"What is the main goal of the study?\",\"answer\":\"To examine how clinical impairment on the Clinical Dementia Rating (CDR-SB) relates to regional glucose metabolism measured by 18F-FDG PET in patients with mild cognitive impairment.\"},{\"question\":\"How was clinical impairment quantified?\",\"answer\":\"Using the Clinical Dementia Rating scale sum of boxes (CDR-SB), derived from six functional and cognitive domains with scores ranging from 0 to 3.\"},{\"question\":\"What relationship did the regression analysis find?\",\"answer\":\"A significant negative association between CDR-SB and glucose metabolism in the right posterior cingulate gyrus, independent of age, gender, and years of school education.\"}]","Cerebral Metabolic Correlates of the Clinical Dementia Rating Scale in Mild Cognitive Impairment | PDF",13]