[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-411175-105":59,"doc-detail-411175-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cerebral-hemodynamics-and-safety-of-ciprofol-in-laparoscopic-bariatric-surgery-a-parallel-double-blind-randomized-controlled-clinical-trial","Cerebral hemodynamics and safety of ciprofol in laparoscopic bariatric surgery: a parallel, double-blind, randomized controlled clinical trial","","Obesity increases perioperative risk because laparoscopic bariatric surgery and pneumoperitoneum can significantly alter intracranial hemodynamics. This randomized, double-blind, parallel-arm clinical trial evaluated ciprofol, a propofol analog, against propofol in obese patients undergoing laparoscopic bariatric surgery. Mean cerebral blood flow velocity (CBFVm), mean arterial pressure (MAP), heart rate, and adverse events were recorded during procedures. Results with 43 participants suggested ciprofol better preserved CBFVm and maintained hemodynamic stability with comparable safety.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cerebral-hemodynamics-and-safety-of-ciprofol-in-laparoscopic-bariatric-surgery-a-parallel-double-blind-randomized-controlled-clinical-trial/411175/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cerebral-hemodynamics-and-safety-of-ciprofol-in-laparoscopic-bariatric-surgery-a-parallel-double-blind-randomized-controlled-clinical-trial/411175.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main purpose of the trial?","Question",{"text":112,"@type":113},"To validate whether ciprofol has superior efficacy in preserving cerebral perfusion and maintaining hemodynamic stability compared with propofol during laparoscopic bariatric surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were brain blood flow and hemodynamic outcomes measured?",{"text":117,"@type":113},"Mean cerebral blood flow velocities were measured using transcranial Doppler ultrasonography, while MAP and heart rate were recorded during surgery along with adverse events.",{"name":119,"@type":110,"acceptedAnswer":120},"What adverse event differed between the two anesthesia groups?",{"text":121,"@type":113},"Pain at the injection site was more common with propofol than with ciprofol (61.9% vs 13.6%).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},411175,1790795165,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","TYPE Clinical Trial  \nPUBLISHED 18 December 2025 DOI 10. 3389/fmed.2025.1726287  \nOPEN ACCESS  \nEDITED BY  \nSomchai Amornyotin,  \nMahidol University, Thailand  \nREVIEWED BY  \nTamer A.A. M. Habeeb, Zagazig University, Egypt Niloofar Khosravi,  \nIran University of Medical Sciences, Iran  \nCerebral hemodynamics and safety of ciprofol in laparoscopic bariatric surgery: a parallel, double-blind, randomized controlled clinical trial  \n*CORRESPONDENCE  \nYalan Li  \n [tyalan@jnu.edu.cn](tyalan@jnu.edu.cn)  \nRECEIVED 16 October 2025  \nREVISED 02 December 2025  \nACCEPTED 05 December 2025  \nPUBLISHED 18 December 2025  \nCITATION  \nLuo Q, Liang S, Wang X, Tian Z and Li Y (2025) Cerebral hemodynamics and safety of ciprofolin laparoscopic bariatric surgery: a parallel, double-blind, randomized controlled clinical trial. Front. Med. 12:1726287 .  \ndoi: 10.3389/fmed.2025.1726287  \nCOPYRIGHT  \n© 2025 Luo, Liang, Wang, Tian and Li. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nQichen Luo1 , Shuqing Liang1 , Xiaoli Wang2 , Zhongyou Tian1 and Yalan Li1*  \n1 Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China, 2Jinan University, Guangzhou, Guangdong Province, China  \nBackground: Obesity has become a global health crisis. Laparoscopic bariatric surgery, a commonly used method for treating obesity, can significantly alter intracranial hemodynamics due to surgical positioning and pneumoperitoneum pressure, thereby increasing the likelihood of perioperative complications in obese individuals. Ciprofol, a novel propofol analog, offers advantages such as reduced side effects and enhanced stability, but its effects on brain blood flow regulation in obese patients are not yet fully understood. This clinical trial was designed to validate its superior efficacy in preserving cerebral perfusion and maintaining hemodynamic stability.  \nMethods: The trial was structured as a randomized, double-blind research with parallel arms. Research was carried out from 1st February 2023 to 30th May 2023 in the First Affiliated Hospital of Jinan University. Patients, with body mass index ranging from 30 .6 to 51 . 2 kg/m2 , scheduled for laparoscopic bariatric surgery, were randomly allocated to receive either propofol or ciprofol. For anesthesia induction and maintenance, participants in each group were administered propofol or ciprofol as the sedative agent. The mean cerebral blood flow velocities (CBFVm) were detected using transcranial doppler ultrasonography, and mean arterial pressure (MAP), heart rate and adverse events were recorded during surgery.  \nResults: A total of 43 patients were ultimately included in this study (21 in the propofol group and 22 in the ciprofol group) . Compared with baseline, patients receiving propofol group exhibited marked reductions in CBFVm at T 1, T2 , T3 , T4 , T5 , T7 , T8 , T9 and MAP at T 1 , T2 , T3 , T5 , T8 (p \u003C 0.05), respectively. In contrast, ciprofol-administered participants demonstrated no significant change in CBFVm, and MAP only showed a significant decrease at T 1 (p \u003C 0.05) . Although there was a certain difference in 􀀂CBFVm between the two groups, it was not statistically significant. Additionally, 13 patients (61 .9%) in the propofol group experienced pain at the injection site, compared to only three patients (13.6%) in the ciprofol group (p = 0.001) . Both groups experienced hypotension, respiratory depression, and bradycardia, but no significant differences were observed. Conclusion: This study found that, compared to propofol, ciprofol may be abetter anesthet","cbCaioN0mpqVdxKQ","https://ap.wps.com/l/cbCaioN0mpqVdxKQ","pdf",2618324,"English","# Introduction\n## Methods\n## Results\n## Conclusion\n## Clinical Trial Registration\n## Keywords","[{\"question\":\"What was the main purpose of the trial?\",\"answer\":\"To validate whether ciprofol has superior efficacy in preserving cerebral perfusion and maintaining hemodynamic stability compared with propofol during laparoscopic bariatric surgery.\"},{\"question\":\"How were brain blood flow and hemodynamic outcomes measured?\",\"answer\":\"Mean cerebral blood flow velocities were measured using transcranial Doppler ultrasonography, while MAP and heart rate were recorded during surgery along with adverse events.\"},{\"question\":\"What adverse event differed between the two anesthesia groups?\",\"answer\":\"Pain at the injection site was more common with propofol than with ciprofol (61.9% vs 13.6%).\"}]","Cerebral hemodynamics and safety of ciprofol in laparoscopic bariatric surgery: a parallel, double-blind, randomized controlled clinical trial | PDF",1790587705,25]