[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443935-105":59,"doc-detail-443935-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","central-nervous-system-vasculitis-mimicking-a-brain-tumor-a-case-report","Central nervous system vasculitis mimicking a brain tumor - A case report","","Central nervous system (CNS) vasculitis is a rare inflammatory disorder of brain and spinal cord blood vessels that produces severe neurological symptoms resembling many other conditions. The report presents a 36-year-old male with subacute progressive left-sided hemiparesis and refractory seizures, emphasizing diagnostic difficulty and the need to integrate multiple imaging modalities, tissue sampling, and biochemical testing. Key imaging features are highlighted to distinguish CNS vasculitis from malignancy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/central-nervous-system-vasculitis-mimicking-a-brain-tumor-a-case-report/443935/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/central-nervous-system-vasculitis-mimicking-a-brain-tumor-a-case-report/443935.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why can CNS vasculitis mimic a brain tumor?","Question",{"text":112,"@type":113},"CNS vasculitis can present with progressive neurological deficits and imaging findings that may resemble malignancy. The diagnostic process requires careful integration of imaging, laboratory testing, and tissue sampling.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What diagnostic steps were required in this case?",{"text":117,"@type":113},"The diagnosis required comprehensive review and integration of different imaging modalities, tissue sampling, and biochemical testing, followed by genetic testing that confirmed primary CNS vasculitis.",{"name":119,"@type":110,"acceptedAnswer":120},"What imaging features may help distinguish CNS vasculitis from other etiologies?",{"text":121,"@type":113},"The case highlights distinctive imaging characteristics, including delayed restricted diffusion onset and rapid progression of vasogenic edema, which can support differentiation from tumor mimics.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443935,1790767562,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Radiology Ca s e Reports 21 (2026) 1150 – 1156  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \njournal [homepage:](homepage: www.elsevier.com/locate/radcr)[ www.elsevier.com/locate/radcr](homepage: www.elsevier.com/locate/radcr)  \n| Case Report\u003Cbr>Central nervous system vasculitis mimicking a brain tumor: A case report ✩\u003Cbr>Uyen N.T. Nguyen, BSa,∗, David Vo, MDb, Kari Hird, MDc, Victoria Wu, MDb, Vanessa Goodwill, MDc, Nikdokht Farid, MDd\u003Cbr>a School of Medicine, University of California San Diego, La Jolla, CA 92093, USA b Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USAc Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA d Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA |  |  |\n| --- | --- | --- |\n| a r t i c l e i n f o |  | a b s t r a c t |\n| Article history:\u003Cbr>Received 29 July 2025 Revised 20 November 2025 Accepted 25 November 2025 |  | Central nervous system (CNS) vasculitis is a rare inflammatory condition of blood vessels of the brain and spinal cord that can result in profound neurological symptoms mimicking many other pathologies. We present the case of a 36-year-old male who presented with subacute onset of progressive left-sided hemiparesis and refractory seizures. The diagnosis was challenging and required comprehensive review and integration of different imaging modalities, tissue sampling, and biochemical testing. This case highlights key imaging features which may aid in distinguishing central nervous system vasculitis from other etiologies such as malignancy.\u003Cbr>© 2025 The Authors. Published by Elsevier Inc. on behalf of University of Washington.\u003Cbr>This is an open access article under the CC BY license\u003Cbr>([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)) |\n| Keywords:\u003Cbr>CNS vasculitis\u003Cbr>Primary angiitis of the central nervous system Heterozygous RAG2 mutation |  |  |\n\nin a 10-year cohort study conducted in Australia [7] . Clinical presentation is usually nonspecific with symptoms such as headache, altered mental status, seizure, and stroke-like symptoms, which overlap with many other neurologic disorders [2] . Serum and CSF biomarkers have limited value for diagnosing CNS vasculitis due to low specificity and sensitivity, but thorough laboratory investigation is warranted to rule out other related etiologies such as malignancy, infection, systemic inflammation, or connective tissue disorders [8,9]. In addition to the clinical picture and laboratory analysis, the diagnosis of primary CNS vasculitis requires incorporation of imaging findings and tissue sampling. Different imag-  \n✩ Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this case report.  \n∗ Corresponding author.  \nE-mail [address:](address: u3nguyen@health.ucsd.edu)[ u3nguyen@health.ucsd.edu](address: u3nguyen@health.ucsd.edu) (U.N.T. Nguyen).  \n[https://doi.org/10.1016/j.radcr.2025.11.068](https://doi.org/10.1016/j.radcr.2025.11.068)  \n1930-0433/© 2025 The Authors. Published by Elsevier Inc. on behalf of University of Washington. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/))  \nFig. 1 – Clinical timeline overview. Abbreviations: Cho/NAA ratio, Choline (Cho) to N-acetylaspartate (NAA) ratio; CRP,  \nC-reactive protein; CSF, cerebrospinal fluid; CT, computed tomography; DSA, digital subtraction angiography; ESR, Erythrocyte Sedimentation Rate; FLAIR, fluid-attenuated inversion recovery; Glu, Glucose; L, left; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; R, right; RBC, red blood cell.  \ning modalities have been used, including CT, MRI, and digital subtraction angiography (DSA), with varying d","cbCaid336o5o8gBa","https://ap.wps.com/l/cbCaid336o5o8gBa","pdf",2195598,"English","# Case report\n## Clinical presentation and initial imaging\n## Diagnostic workup (laboratory, imaging, tissue sampling)\n## Genetic testing and final diagnosis\n## Key imaging features and clinical implications","[{\"question\":\"Why can CNS vasculitis mimic a brain tumor?\",\"answer\":\"CNS vasculitis can present with progressive neurological deficits and imaging findings that may resemble malignancy. The diagnostic process requires careful integration of imaging, laboratory testing, and tissue sampling.\"},{\"question\":\"What diagnostic steps were required in this case?\",\"answer\":\"The diagnosis required comprehensive review and integration of different imaging modalities, tissue sampling, and biochemical testing, followed by genetic testing that confirmed primary CNS vasculitis.\"},{\"question\":\"What imaging features may help distinguish CNS vasculitis from other etiologies?\",\"answer\":\"The case highlights distinctive imaging characteristics, including delayed restricted diffusion onset and rapid progression of vasogenic edema, which can support differentiation from tumor mimics.\"}]","Central nervous system vasculitis mimicking a brain tumor - A case report | PDF",1790706140,18]