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The document outlines strong genetic association (notably HLA-linked risk), typical histological changes (villus atrophy, crypt hyperplasia, intraepithelial lymphocytes, epithelial surface damage), and common clinical presentations such as chronic greasy pale bulky diarrhea in early childhood, failure to thrive, and finger clubbing, with extra-intestinal complications including iron-deficiency anemia, osteoporosis, neurologic and dental manifestations. Diagnosis emphasizes serology, HLA testing, and gluten-dependent biopsy confirmation; management centers on lifelong gluten-free diet and steroid use in crisis. Cystic fibrosis is presented as an autosomal recessive CFTR gene disorder causing increased sweat NaCl, chronic progressive multi-organ disease with neonatal, respiratory, and gastrointestinal/endocrine features, diagnostic confirmation via sweat chloride testing and DNA analysis, and symptom-based management. Small bowel bacterial overgrowth (SIBO) is introduced as increased or altered small-bowel bacterial burden causing GIT disturbances, including key microbiologic thresholds and principal causes such as reduced gastric acidity and impaired motility.",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/celiac-disease-cystic-fibrosis-sibo/25834/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/celiac-disease-cystic-fibrosis-sibo/25834.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-20","2026-05-07",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/celiac-disease-cystic-fibrosis-sibo/25834","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},25834,1778194888,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":122,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":123,"seo_description":67,"update_tm":113,"read_time":124},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","cbCaikMYqrE4WcgN","https://ap.wps.com/l/cbCaikMYqrE4WcgN","pdf",690762,"English","Celiac Disease, Cystic Fibrosis & SIBO | PDF",18]