[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372289-105":59,"doc-detail-372289-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cdk46-inhibitor-associated-vortex-keratopathy-a-case-report","CDK4/6 inhibitor-associated vortex keratopathy - a case report","","Cyclin-dependent kinase (CDK) 4/6 inhibitors are anticancer drugs that arrest the cell cycle and slow tumor progression, but rare ocular adverse effects are increasingly important. This case report describes a 60-year-old woman with metastatic breast cancer who developed vortex keratopathy while receiving tiremciclib (CDK4/6 inhibitor) combined with fulvestrant. Slit-lamp, AS-OCT, and corneal confocal microscopy confirmed the diagnosis. Symptoms improved slightly with artificial lubricating eye drops, and corneal confocal microscopy provided detailed drug-related findings.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cdk46-inhibitor-associated-vortex-keratopathy-a-case-report/372289/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cdk46-inhibitor-associated-vortex-keratopathy-a-case-report/372289.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition is described in this case report?","Question",{"text":112,"@type":113},"The report describes CDK4/6 inhibitor-associated vortex keratopathy, a corneal epithelial whorl-like opacity pattern.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancer therapy was linked to the onset of vortex keratopathy?",{"text":117,"@type":113},"Vortex keratopathy was associated with the use of tiremciclib, a novel CDK4/6 inhibitor, given together with fulvestrant.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the diagnosis confirmed?",{"text":121,"@type":113},"Diagnosis was established using slit-lamp examination, anterior segment optical coherence tomography (AS-OCT), and corneal confocal microscopy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372289,1790698157,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Shu et al. BMC Ophthalmology (2025) 25:206 [https://doi.org/10.1186/s12886-025-04043-6](https://doi.org/10.1186/s12886-025-04043-6)  \nBMC Ophthalmology  \nCASE REPORT Open Access  \nCDK4/6 inhibitor-associated vortex keratopathy: a case report  \nLian Shu 1, Xinhan Cui 1, Yan Wang 1 and Xinghuai Sun 1,2*  \nAbstract  \nBackground Cyclin-dependent kinase (CDK) 4/6 inhibitors are novel anticancer drugs that can arrest the cell cycle and halt the progression of cancers. This study presents a rare case of vortex keratopathy associated with the use of a cyclin-dependent kinase (CDK) 4/6 inhibitor for breast cancer treatment.  \nPatient presentation A 60-year-old female patient with a one-year history of eye irritation presented at our hospital. She had been diagnosed with metastatic breast cancer two years prior and received treatment with tiremciclib (a novel CDK4/6 inhibitor) in combination with fulvestrant at the same time. After slit-lamp examination, anterior segment optical coherence tomography (AS-OCT), and corneal confocal microscopy, the patient was diagnosed with vortex keratopathy. The ocular symptoms of the patient improved slightly after the use of artificial lubricating eye drops.  \nConclusions This case demonstrates the ocular characteristics and novel findings of corneal confocal microscopy of CDK4/6 inhibitor-related vortex keratopathy. Our findings increase the understanding of the pathophysiological mechanisms of drug-induced vortex keratopathy and increase our awareness of ocular manifestations in patients receiving novel anticancer drugs.  \nKeywords Vortex keratopathy, Corneal verticil late, CDK4/6 inhibitor, Corneal confocal microscopy  \nBackground  \nCyclin-dependent kinases (CDKs), a class of serine/threonine protein kinases, are involved in the regulation of the cell cycle, transcription initiation, and control of certain metabolic cascades. Among these, CDK4/6 is a key factor in cell cycle regulation and can trigger the transition of the cell cycle from the G1 phase (growth phase)  \n*Correspondence: Xinghuai Sun [xhsun@shmu.edu.cn](xhsun@shmu.edu.cn)  \n1Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, No.83 Fenyang Road, Shanghai 200031, China  \n2State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China  \nto the S phase (DNA replication phase). Inhibitors targeting CDK4/6 are an important class of targeted anticancer drugs that can arrest the cell cycle at the G1 phase and halt the progression of various cancers, especially breast cancer [1, 2]. According to previous studies, common adverse reactions to CDK4/6 inhibitors primarily include bone marrow suppression, gastrointestinal discomfort, and liver function abnormalities [2].  \nVortex keratopathy, also called corneal verticillate, is a rare form of corneal degeneration characterized by whorl-like opacity in the corneal epithelium. Although the specific mechanism remains unclear, it might result from dysfunctional lipid storage in the lysosomes of corneal epithelial cells, leading to abnormal accumulation of intracellular lipid complexes [3]. Primary lysosomal storage diseases include Fabry disease, a rare genetic  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line t","cbCaiqLnWolPuLPk","https://ap.wps.com/l/cbCaiqLnWolPuLPk","pdf",1211694,"English","# Abstract\n## Background\n## Patient presentation\n## Conclusions\n# Background\n## CDK4/6 inhibitors and adverse reactions\n## Vortex keratopathy mechanisms\n# Case presentation","[{\"question\":\"What condition is described in this case report?\",\"answer\":\"The report describes CDK4/6 inhibitor-associated vortex keratopathy, a corneal epithelial whorl-like opacity pattern.\"},{\"question\":\"Which cancer therapy was linked to the onset of vortex keratopathy?\",\"answer\":\"Vortex keratopathy was associated with the use of tiremciclib, a novel CDK4/6 inhibitor, given together with fulvestrant.\"},{\"question\":\"How was the diagnosis confirmed?\",\"answer\":\"Diagnosis was established using slit-lamp examination, anterior segment optical coherence tomography (AS-OCT), and corneal confocal microscopy.\"}]","CDK4/6 inhibitor-associated vortex keratopathy - a case report | PDF",1790194163,13]